Fig. 1

Clinical, molecular and histological features of this refractory AML patients.(A) The morphology of bone marrow (BM) blasts(× 1000). (B) The immunophenotype of BM blasts at diagnosis. Red colors in J region represent BM blasts. Flow cytometry determines 45% blasts and demonstrates MPO, CD38 and HLA-DR dim expression, CD33, CD117, CD13, CD34, CD9 and CD123 positivity, while CD2, CD5, CD7, CD10, CD19, CD79a, CD11b negativity. (C) The immunophenotype of peripheral blood cells when leukemocytosis ensues. Red and blue colors illustrate two leukemia clones. (D) Leukemia cutis in this patient. (E) The morphology analysis in skin biopsy sample (H&E × 100). (F) The immunohistochemistry displays MPO positive in skin biopsy sample (× 100). (G) The immunohistochemistry displays CD15 positive in skin biopsy sample (× 100). (H) The immunohistochemistry displays BCL-2 positive in blasts of the bone marrow biopsy (× 100). (I) The immunohistochemistry displays a morsol of BCL-2 positive in skin biopsy sample (× 100)