Table 2 Associations between LY6D expression and clinicopathological characteristics in Cohort III
LY6D expression | TURB | Cystectomy | ||||||
|---|---|---|---|---|---|---|---|---|
0 | 1 | 2 | P-value | 0 | 1 | 2 | P-value | |
n(%) | 74 (51.4) | 42 (29.2) | 28 (19.4) | 56 (55.4) | 32 (31.7) | 13 (12.9) | ||
Age | ||||||||
Mean, median | 67.8, 69.7 | 69.6, 70.6 | 69.6, 72.5 | 0.421 | 69.7, 72.6 | 70.3, 70.6 | 74.0, 74.3 | 0.288 |
range | 38.7–83.3 | 45.6–90.0 | 48.0–81.7 | 38.7–82.7 | 50.3–81.7 | 57.6–83.3 | ||
Sex | ||||||||
Male | 57 (77) | 37 (88.1) | 20 (71.4) | 0.878 | 44 (78.6) | 26 (81.3) | 9 (69.2) | 0.644 |
Female | 17 (23) | 5 (11.9) | 8 (28.6) | 12 (21.4) | 6 (18.8) | 4 (30.8) | ||
Preoperative T-stage | ||||||||
T2 | 44 (59.5) | 20 (47.6) | 12 (42.9) | 0.018 | 26 (46.4) | 16 (50.0) | 7 (53.8) | 0.677 |
T3 | 26 (35.1) | 14 (33.3) | 10 (35.7) | 21 (37.5) | 14 (43.8) | 4 (30.8) | ||
T4 | 4 (5.4) | 8 (19.0) | 6 (21.4) | 9 (16.1) | 2 (6.3) | 2 (15.4) | ||
Postoperative T-stage | ||||||||
pT0/pTa/CIS only | 26 (35.1) | 14 (33.3) | 4 (14.3) | 0.093 | 7 (12.5)a | 5 (15.6) | 2 (15.4) | 0.349 |
pT1 | 7 (9.5) | 4 (9.5) | 2 (7.1) | 6 (10.7) | 4 (12.5) | 1 (7.7) | ||
pT2 | 14 (18.9) | 8 (19.0) | 7 (25.0) | 11 (19.6) | 6 (18.8) | 3 (23.1) | ||
pT3 | 19 (25.7) | 10 (23.8) | 13 (46.4) | 20 (35.7) | 14 (43.8) | 7 (53.8) | ||
pT4 | 8 (10.8) | 6 (14.3) | 2 (7.1) | 12 (21.4) | 3 (9.4) | 0 (0.0) | ||
N-stage | ||||||||
N0 | 51 (68.9) | 31 (73.8) | 20 (71.4) | 0.818 | 31 (55.4) | 23 (71.9) | 11 (84.6) | 0.017 |
N1 | 8 (10.8) | 5 (11.9) | 3 (10.7) | 7 (12.5) | 3 (9.4) | 2 (15.4) | ||
N2 | 8 (10.8) | 4 (9.5) | 1 (3.6) | 10 (17.9) | 2 (6.3) | 0 (0.0) | ||
N3 | 7 (9.5) | 2 (4.8) | 4 (14.3) | 8 (14.3) | 4 (12.5) | 0 (0.0) | ||
LVI in cystectomy | ||||||||
No | 46 (93.9) | 26 (89.7) | 23 (100.0) | 0.448 | 44 (89.8) | 26 (92.9) | 12 (100.0) | 0.253 |
Yes | 3 (6.1) | 3 (10.3) | 0 (0.0) | 5 (10.2) | 2 (7.1) | 0 (0.0) | ||
Missing | 25 | 13 | 5 | 7 | 4 | 1 | ||
CIS in TURB specimens | ||||||||
Not found | 69 (93.2) | 34 (81.0) | 26 (92.9) | 0.532 | 49 (87.5) | 28 (87.5) | 13 (100.0) | 0.299 |
Found | 5 (6.8) | 8 (19.0) | 2 (7.1) | 7 (12.5) | 4 (12.5) | 0 (0.0) | ||
CIS in cystectomy specimens | ||||||||
Not found | 60 (81.1) | 34 (81.0) | 25 (89.3) | 0.396 | 40 (71.4) | 25 (78.1) | 13 (100.0) | 0.039 |
Found | 14 (18.9) | 8 (19.0) | 3 (10.7) | 16 (28.6) | 7 (21.9) | 0 (0.0) | ||
NAC | ||||||||
No | 39 (52.7) | 21 (50.0) | 19 (67.9) | 0.262 | 40 (71.4) | 22 (68.8) | 10 (76.9) | 0.840 |
Yes | 35 (47.3) | 21 (50.0) | 9 (32.1) | 16 (28.6) | 10 (31.3) | 3 (23.1) | ||