Table 1 Associations between LY6D expression and clinicopathological characteristics in Cohorts I and II
LY6D expression | Cohort I | Cohort II | ||||||
|---|---|---|---|---|---|---|---|---|
0 | 1 | 2 | P-value | 0 | 1 | 2 | P-value | |
n(%) | 37 (37.0) | 20 (20.0) | 43 (43.0) | 93 (35.8) | 92 (36.5) | 72 (27.7) | ||
Age | ||||||||
Mean, median | 73.3, 75,4 | 70.0, 67.0 | 68.0, 66.1 | 0.174 | 71.1, 71.2 | 71.2, 70.3 | 71.8, 72.7 | 0.674 |
range | 40.1–88.5 | 46.0–84.3 | 39.3–89.9 | 52.0–85.0 | 52.9–86.6 | 51.2–86.8 | ||
Sex | ||||||||
Male | 32 (86.5) | 9 (45.0) | 33 (76.7) | 0.382 | 72 (77.6) | 64 (67.4) | 44 (61.1) | 0.023 |
Female | 5 (13.5) | 11 (55.0) | 10 (23.3) | 21 (22.6) | 31 (32.6) | 28 (38.9) | ||
pT-stage | ||||||||
pTa | 11 (29.7) | 9 (45.0) | 12 (42.9) | 0.020 | 26 (28.0) | 49 (51.6) | 39 (54.2) | < 0.001 |
pT1 | 10 (27.0) | 4 (20.0) | 10 (35.7) | 32 (34.4) | 29 (30.5) | 20 (27.8) | ||
≥ pT2 | 16 (43.2) | 7 (35.0) | 6 (21.4) | 35 (37.6) | 17 (17.9) | 13 (18.1) | ||
Grade | ||||||||
Low | 9 (24.3) | 9 (45.0) | 29 (67.4) | < 0.001 | 21 (22.6) | 61 (64.2) | 44 (61.1) | < 0.001 |
High | 28 (75.7) | 11 (55.0) | 14 (32.6) | 72 (77.4) | 45 (35.8) | 28 (38.9) | ||
Histology | ||||||||
Classic | – | – | – | 68 (73.1) | 81 (85.3) | 60 (83.3) | 0.016 | |
Squamous | – | – | – | 4 (4.3) | 3 (3.2) | 7 (9.7) | ||
Other variant | – | – | – | 21 (22.6) | 11 (11.6) | 5 (6.9) | ||
Smoking history | ||||||||
Regularly | – | – | – | 32 (34.4) | 33 (34.7) | 30 (41.7) | 0.184 | |
Occasionally | – | – | – | 5 (5.4) | 3 (3.2) | 7 (9.7) | ||
Former | – | – | – | 39 (41.9) | 44 (46.3) | 26 (36.1) | ||
Never | – | – | – | 17 (18.3) | 15 (15.8) | 9 (12.5) | ||