|
LY6D expression
|
Cohort I
|
Cohort II
|
|---|
|
0
|
1
|
2
|
P-value
|
0
|
1
|
2
|
P-value
|
|---|
|
n(%)
|
37 (37.0)
|
20 (20.0)
|
43 (43.0)
| |
93 (35.8)
|
92 (36.5)
|
72 (27.7)
| |
|
Age
|
|
Mean, median
|
73.3, 75,4
|
70.0, 67.0
|
68.0, 66.1
|
0.174
|
71.1, 71.2
|
71.2, 70.3
|
71.8, 72.7
|
0.674
|
|
range
|
40.1–88.5
|
46.0–84.3
|
39.3–89.9
| |
52.0–85.0
|
52.9–86.6
|
51.2–86.8
| |
|
Sex
|
|
Male
|
32 (86.5)
|
9 (45.0)
|
33 (76.7)
|
0.382
|
72 (77.6)
|
64 (67.4)
|
44 (61.1)
|
0.023
|
|
Female
|
5 (13.5)
|
11 (55.0)
|
10 (23.3)
| |
21 (22.6)
|
31 (32.6)
|
28 (38.9)
| |
|
pT-stage
|
|
pTa
|
11 (29.7)
|
9 (45.0)
|
12 (42.9)
|
0.020
|
26 (28.0)
|
49 (51.6)
|
39 (54.2)
|
< 0.001
|
|
pT1
|
10 (27.0)
|
4 (20.0)
|
10 (35.7)
| |
32 (34.4)
|
29 (30.5)
|
20 (27.8)
| |
|
≥ pT2
|
16 (43.2)
|
7 (35.0)
|
6 (21.4)
| |
35 (37.6)
|
17 (17.9)
|
13 (18.1)
| |
|
Grade
|
|
Low
|
9 (24.3)
|
9 (45.0)
|
29 (67.4)
|
< 0.001
|
21 (22.6)
|
61 (64.2)
|
44 (61.1)
|
< 0.001
|
|
High
|
28 (75.7)
|
11 (55.0)
|
14 (32.6)
| |
72 (77.4)
|
45 (35.8)
|
28 (38.9)
| |
|
Histology
|
|
Classic
|
–
|
–
|
–
| |
68 (73.1)
|
81 (85.3)
|
60 (83.3)
|
0.016
|
|
Squamous
|
–
|
–
|
–
| |
4 (4.3)
|
3 (3.2)
|
7 (9.7)
| |
|
Other variant
|
–
|
–
|
–
| |
21 (22.6)
|
11 (11.6)
|
5 (6.9)
| |
|
Smoking history
|
|
Regularly
|
–
|
–
|
–
| |
32 (34.4)
|
33 (34.7)
|
30 (41.7)
|
0.184
|
|
Occasionally
|
–
|
–
|
–
| |
5 (5.4)
|
3 (3.2)
|
7 (9.7)
| |
|
Former
|
–
|
–
|
–
| |
39 (41.9)
|
44 (46.3)
|
26 (36.1)
| |
|
Never
|
–
|
–
|
–
| |
17 (18.3)
|
15 (15.8)
|
9 (12.5)
| |
- P-value < 0.05 is considered significant
- 0 = Negative LY6D expression, 1 = ≤ 50% positive LY6D expression, 2 = > 50% LY6D expression
