Table 2 Ferroptosis inducers
From: Novel insights on targeting ferroptosis in cancer therapy
Category | Molecule | Target |
|---|---|---|
SystemXc− Inhibition | Erastin | SystemXc−/VDAC/TFR1 |
SAS | SystemXc− | |
SRF | SystemXc− | |
GPX4 Inhibition | RSL3/5 | GPX4/VDAC |
FINs | GPX4 | |
FINO2 | GPX4 | |
DPIs | GPX4 | |
Altretamine | GPX4 | |
Withaferin A | GPX4 | |
Others classes | GLU | Cystine |
Iron carrier | Iron | |
BSO | GSH | |
DPI2 | GSH | |
Cisplatin | GSH | |
Artemisinin and derivative | Iron | |
Nanoparticle inducers | Â |