Table 1 Biomarkers for ferroptosis
From: Novel insights on targeting ferroptosis in cancer therapy
Core molecules markers | Biochemistry | Morphology |
|---|---|---|
①Pro-ferroptosis: TFR1 VDAC2/3 Ras P53 NOX ②Anti-ferroptosis: SLC7A11 HSPB1 NRF2 GSH GPX4 | ①Activation of MAPKs ②Iron and ROS accumulation ③Inhibition of system Xc− with decreased cystine uptake ④GSH depletion ⑤Increased NAPDH oxidation | ①Round and detached cell cytoplasm ②Condensed mitochondrial membrane densities ③Reduced or vanishing mitochondria crista ④Outer mitochondrial membrane rupture |