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Table 1 Biomarkers for ferroptosis

From: Novel insights on targeting ferroptosis in cancer therapy

Core molecules markers Biochemistry Morphology
Pro-ferroptosis:
TFR1
VDAC2/3
Ras
P53
NOX
Anti-ferroptosis:
SLC7A11
HSPB1
NRF2
GSH
GPX4
Activation of MAPKs
Iron and ROS accumulation
Inhibition of system Xc with decreased cystine uptake
GSH depletion
Increased NAPDH oxidation
Round and detached cell cytoplasm
Condensed mitochondrial membrane densities
Reduced or vanishing mitochondria crista
Outer mitochondrial membrane rupture