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Table 4 Summary results of the meta-analysis of odd ratio of each Biomarker in severe vs non-severe cases

From: A meta-analysis of potential biomarkers associated with severity of coronavirus disease 2019 (COVID-19)

Anomalies RR (95% CI) P-value Heterogeneity
I2 (%)
Number of studies Sample size for severe Sample size for non-severe
Inflammation
 Eleveted procalcitonin 2.94 (2.09; 4.15) < 0.001 32 9 321 941
 Eleveted CRP 1.41 (1.17; 1.70) 0.003 0 8 328 1021
Blood routine
 Lymphopenia 1.66(1.26;2.20) 0.002 30 11 411 1225
 Leucopenia 0.93(0.46;1.86) 0.81 83 10 384 1300
 Thrombocytopenia 1.86(1.59;2.17) < 0.001 0 5 250 976
 Thrombocytosis 0.88(0.26;2.95) 0 2 53 122
Biochemestry
 Eleveted LDH 2.03(1.42;2.90) 0.003 57 7 239 899
 Eleveted ASAT 2.27(1.76;2.94) < 0.001 26 8 354 1184
 Eleveted ALAT 160(1.34;1.90) 0.002 60 5 283 1042
 Eleveted CK 2.61(1.35;5.05) 0.01 37 6 248 841
 Eleveted Creatininemia 3.66(1.53; 8.81) 0.02 0 4 227 857
 Eleveted total bilirubin 1.42(0.18;11.26) 0.28 0 2 158 725
Blood clothing
 D-dimer 1.50(0.89; 2.56) 0.08 0 3 156 510
  1. OR odd ratio; CRP C-reactive protein; CK Creatine kinase; IL-6 interleukin-6; ALAT alanine amino-transferase;
  2. ASAT aspartate amino-transferase; LDH Lactate dehydrogenese