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Table 4 Summary results of the meta-analysis of odd ratio of each Biomarker in severe vs non-severe cases

From: A meta-analysis of potential biomarkers associated with severity of coronavirus disease 2019 (COVID-19)

Anomalies

RR (95% CI)

P-value

Heterogeneity

I2 (%)

Number of studies

Sample size for severe

Sample size for non-severe

Inflammation

 Eleveted procalcitonin

2.94 (2.09; 4.15)

< 0.001

32

9

321

941

 Eleveted CRP

1.41 (1.17; 1.70)

0.003

0

8

328

1021

Blood routine

 Lymphopenia

1.66(1.26;2.20)

0.002

30

11

411

1225

 Leucopenia

0.93(0.46;1.86)

0.81

83

10

384

1300

 Thrombocytopenia

1.86(1.59;2.17)

< 0.001

0

5

250

976

 Thrombocytosis

0.88(0.26;2.95)

0

2

53

122

Biochemestry

 Eleveted LDH

2.03(1.42;2.90)

0.003

57

7

239

899

 Eleveted ASAT

2.27(1.76;2.94)

< 0.001

26

8

354

1184

 Eleveted ALAT

160(1.34;1.90)

0.002

60

5

283

1042

 Eleveted CK

2.61(1.35;5.05)

0.01

37

6

248

841

 Eleveted Creatininemia

3.66(1.53; 8.81)

0.02

0

4

227

857

 Eleveted total bilirubin

1.42(0.18;11.26)

0.28

0

2

158

725

Blood clothing

 D-dimer

1.50(0.89; 2.56)

0.08

0

3

156

510

  1. OR odd ratio; CRP C-reactive protein; CK Creatine kinase; IL-6 interleukin-6; ALAT alanine amino-transferase;
  2. ASAT aspartate amino-transferase; LDH Lactate dehydrogenese