Table 3 Diagnostic performance of FibroBox, TE, APRI and FIB-4 in the validation cohorts (Anhui and Beijing)

 AUROC (95% CI)

0.88 (0.84 to 0.92)

0.87 (0.82 to 0.92)

0.87 (0.83 to 0.91)

0.90 (0.85 to 0.94)

 Cut-off values

0.38

0.56

0.38

0.56

 Sensitivity/specificity (%)

80/82

78/81

75/88

72/90

 Correctly classified (%)

81

81

82

88

 PPV/NPV (%)

89/71

51/94

84/81

49/96

 Positive/negative LR

4.5/0.2

4.1/0.3

6.2/0.3

7.2/0.3

 AUROC (95% CI)

0.84 (0.79 to 0.88)

0.84 (0.78 to 0.90)

0.82 (0.77 to 0.87)

0.89 (0.85 to 0.94)

 Cut-off values

7.8

11.3

7.8

11.3

 Sensitivity/specificity (%)

77/82

75/85

77/84

95/69

 Correctly classified (%)

79

83

81

72

 PPV/NPV (%)

88/67

55/93

79/82

29/99

 Positive/negative LR

4.4/0.3

4.8/0.3

4.7/0.3

3.0/0.1

 AUROC (95% CI)

0.66 (0.60 to 0.73)

0.72 (0.65 to 0.79)

0.70 (0.65 to 0.76)

0.75 (0.67 to 0.82)

 Cut-off values

0.50

0.50

0.43

0.62

 Sensitivity/specificity (%)

64/70

81/56

75/58

69/69

 Correctly classified (%)

67

61

66

69

 PPV/NPV (%)

79/54

32/92

59/74

23/94

 Positive/negative LR

2.2/0.5

1.8/0.3

1.8/0.4

2.2/0.4

 AUROC (95% CI)

0.68 (0.62 to 0.74)

0.79 (0.72 to 0.86)

0.67 (0.61 to 0.73)

0.70 (0.62 to 0.79)

 Cut-off values

1.71

1.62

1.20

1.20

 Sensitivity/specificity (%)

44/87

75/75

58/71

71/62

 Correctly classified (%)

60

75

65

63

 PPV/NPV (%)

85/47

43/92

62/67

20/94

 Positive/negative LR

3.4/0.6

3.0/0.3

2.0/0.6

1.9/0.5

 FibroBox and TE

< 0.001

0.058

< 0.001

0.863

 FibroBox and APRI

< 0.001

< 0.001

< 0.001

< 0.001

 FibroBox and FIB-4

< 0.001

0.015

< 0.001

< 0.001

 TE and APRI

< 0.001

0.007

< 0.001

< 0.001

 TE and FIB-4

< 0.001

0.264

< 0.001

< 0.001

 APRI and FIB-4

0.575

0.009

0.264

0.211