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Table 3 Diagnostic performance of FibroBox, TE, APRI and FIB-4 in the validation cohorts (Anhui and Beijing)

From: FibroBox: a novel noninvasive tool for predicting significant liver fibrosis and cirrhosis in HBV infected patients

Validation cohorts Anhui (n = 408) Beijing (n = 332)
F0–1 vs F2–4 F0–3 vs F4 F0–1 vs F2–4 F0–3 vs F4
FibroBox
 AUROC (95% CI) 0.88 (0.84 to 0.92) 0.87 (0.82 to 0.92) 0.87 (0.83 to 0.91) 0.90 (0.85 to 0.94)
 Cut-off values 0.38 0.56 0.38 0.56
 Sensitivity/specificity (%) 80/82 78/81 75/88 72/90
 Correctly classified (%) 81 81 82 88
 PPV/NPV (%) 89/71 51/94 84/81 49/96
 Positive/negative LR 4.5/0.2 4.1/0.3 6.2/0.3 7.2/0.3
TE
 AUROC (95% CI) 0.84 (0.79 to 0.88) 0.84 (0.78 to 0.90) 0.82 (0.77 to 0.87) 0.89 (0.85 to 0.94)
 Cut-off values 7.8 11.3 7.8 11.3
 Sensitivity/specificity (%) 77/82 75/85 77/84 95/69
 Correctly classified (%) 79 83 81 72
 PPV/NPV (%) 88/67 55/93 79/82 29/99
 Positive/negative LR 4.4/0.3 4.8/0.3 4.7/0.3 3.0/0.1
APRI
 AUROC (95% CI) 0.66 (0.60 to 0.73) 0.72 (0.65 to 0.79) 0.70 (0.65 to 0.76) 0.75 (0.67 to 0.82)
 Cut-off values 0.50 0.50 0.43 0.62
 Sensitivity/specificity (%) 64/70 81/56 75/58 69/69
 Correctly classified (%) 67 61 66 69
 PPV/NPV (%) 79/54 32/92 59/74 23/94
 Positive/negative LR 2.2/0.5 1.8/0.3 1.8/0.4 2.2/0.4
FIB-4
 AUROC (95% CI) 0.68 (0.62 to 0.74) 0.79 (0.72 to 0.86) 0.67 (0.61 to 0.73) 0.70 (0.62 to 0.79)
 Cut-off values 1.71 1.62 1.20 1.20
 Sensitivity/specificity (%) 44/87 75/75 58/71 71/62
 Correctly classified (%) 60 75 65 63
 PPV/NPV (%) 85/47 43/92 62/67 20/94
 Positive/negative LR 3.4/0.6 3.0/0.3 2.0/0.6 1.9/0.5
Comparison of AUROC
 FibroBox and TE < 0.001 0.058 < 0.001 0.863
 FibroBox and APRI < 0.001 < 0.001 < 0.001 < 0.001
 FibroBox and FIB-4 < 0.001 0.015 < 0.001 < 0.001
 TE and APRI < 0.001 0.007 < 0.001 < 0.001
 TE and FIB-4 < 0.001 0.264 < 0.001 < 0.001
 APRI and FIB-4 0.575 0.009 0.264 0.211
  1. APRI AST-to-platelet ratio index, AST aspartate transaminase, AUROC area under the receiver operating characteristic curve, LR likelihood ratio, NPV negative predictive value, PPV positive predictive value, TE transient elastography