Fig. 3

The new genetic predictive model for POD12 including CD79B mutation, PIM1 mutation, and LDH levels. (a) The incidence of POD12 was significantly different between patients with scores of 0–1 (n = 104) and 2–4 (n = 41) based on the genetic predictive model (21.15% vs 65.85%, p = 0.000). (b) There was an inverse correlation on PFS (p = 0.000) and OS (p = 0.018) between patients with score of 0–1 (n = 104) and 2–4 (n = 41). (c) The genetic predictive model was validated in a cohort of 84 DLBCL cases. (d) The association of scores of 2–4 (n = 119) with poorer survival was confirmed in a larger cohort (p = 0.000). (e) The genetic predictive model for POD12 outperformed the IPI score and MCD subtype