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Table 2 Univariate and multivariate analyses of the overall survival of patients

From: Plasma circulating tumor DNA assessment reveals KMT2D as a potential poor prognostic factor in extranodal NK/T-cell lymphoma

Prognostic variables Univariate analysis Multivariate analysis
HR (95% CI) p value HR (95% CI) p value
Gender (female vs. male) 0.712 (0.279–1.812) 0.476   
Stage (I-II vs. III-IV) 2.625 (1.043–6.604) 0.04 1.159 (0.253–5.311) 0.849
B symphony (with vs. without) 1.234 (0.512–2.973) 0.64   
IPI 2.595 (1.073–6.277) 0.034 0.565 (0.118–2.712) 0.476
Final recurrence status 3.346 (1.364–8.204) 0.008 2.705 (0.941–7.776) 0.065
MTV 2.069 (0.843–5.078) 0.112   
ctDNA concentration 2.975 (0.984–8.997) 0.053   
EBV-DNA level 3.672 (1.396–9.664) 0.008 3.174 (1.091–9.231) 0.034
KMT2D mutation (without vs. with) 0.289 (0.119–0.702) 0.006 0.266 (0.086–0.828) 0.022
APC mutation (without vs. with) 0.550 (0.16–1.895) 0.344   
ATM mutation (without vs. with) 0.271 (0.098–0.752) 0.012 0.212 (0.064–0.700) 0.011
ASXL3 mutation (without vs. with) 2613 (0.347–19.68) 0.351   
JAK3 mutation (without vs. with) 0.569 (0.166–1.949) 0.369   
SETD2 mutation (without vs. with) 0.804 (0.184–3.507) 0.771   
TP53 mutation (without vs. with) 0.615 (0.179–2.115) 0.441   
NOTCH1 mutation (without vs. with) 0.410 (0.120–1.406) 0.156