Fig. 5

Serial ctDNA detection during therapy could complement the response assessment of the patients. Treatment response assessment using PET/CT was combined with genomic testing of the ctDNA and plasma EBV-DNA levels. Plasma and imaging were performed at baseline prior to treatment initiation, before the start of cycle 4 (C4), and before cycle 8 (C8). Displayed are recruited patients with serial plasma collection and their responses to treatment using the plasma EBV-DNA, ctDNA assessment and PET/CT scans