Skip to main content

Table 1 The role of m6A regulators in different cancers

From: The emerging roles of N6-methyladenosine RNA methylation in human cancers

m6A regulators Cancer type Role in cancer Genes involved Mechanism Reference
Writers
 METTL3 GBCa Oncogene SOX2 Enhances the stemness of GSCs by facilitating expression of SOX2 [58]
   SRSFs Enhances the stemness of GSCs by increasing the NMD of SRSFs in YTHDC1-dependent way [59]
  Antioncogene ADAM19 Inhibits the stemness of GSCs by promoting the expression of ADAM19 [60, 61]
LC Oncogene EGFR TAZ MK2 DNMT3 Enhances the stemness of LC stem cells by promoting expression of EGFR, TAZ, MK2 and DNMT3 [53]
   VASH1 Promotes brain metastasis of LC by inhibiting the expression of VASH1 via up-regulated miR-143-3p [70]
HCC Oncogene SOCS2 Increases the decay of tumor suppressor SOCS2 via YTHDF2 in m6A-dependent way [76]
   Snail Promotes the progress of EMT by regulating the expression of Snail in YTHDC1-dependent way [77]
   HDGF Up-regulates the level of LINC00958 and promotes the expression of HDGF by inhibiting miR-3619-5p [78]
GC Oncogene MYC Enhances the expression of oncogene MYC [86]
   Bcl2 Inhibits the apoptosis of GC cells by up-regulating the expression of Bcl2 via competitive inhibition with Bax [10]
   SEC62 Promotes the expression of SEC62 with the help of IGF2BP1 [88]
   HDFG Promotes the expression of HDFG with the help of IGF2BP3 [89]
CRCa Oncogene SOX2 Enhances the proliferation of CRC cells by facilitating expression of SOX2 in a m6A-IGF2BP2-dependent mechanism [92, 93]
  Antioncogene ? Inhibits the proliferation, metastasis in CRC by suppressing the p38/ERK signaling pathways [94]
ccRCC Antioncogene NANOG Inhibits the stemness of ccRCC cells by reducing the expression of NANOG [103]
   VHL Inhibits the stemness of ccRCC cells by up-regulating the expression of VHL and reducing the level of HIF-α [103]
BC Oncogene SETD7 KLF4 Facilitates the degradation of tumor suppressor m6A-modified SETD7 mRNA and m6A-modified KLF4 mRNA in YTHDF2-dependent way [110]
   ITGA6 Promotes the expression of oncogene ITGA6 in YTHDF1 and YTHDF3 dependent way [111]
EC Antioncogene PHLPP2 mTORC Promotes the excessive activation of AKT by reducing expression of PHLPP2 and increasing expression of mTORC [116]
OC Oncogene RHPN1-AS1 Promotes the expression of RHPN1-AS1 and activates FAK/PI3K/Akt pathway [117]
Breast cancera Antioncogene NANOG Inhibits the stemness of BCSCs by reducing the translation of NANOG [119]
   KLF4 Inhibits the stemness of BCSCs by reducing the translation of KLF4 [119]
  Oncogene HBXIP Enhances the stemness of BCSCs by increasing the expression of HBXIP [120]
   MAGI3 switches the role of MAGI3 from antioncogene to an oncogene in m6A-dependent way [121]
   Bcl2 Promotes the expression of Bcl2 [122]
AML Oncogene SP1 c-MYC Promotes the expression of SP1 and enhance its function to activate oncogene c-MYC [127]
  Oncogene Bcl2 PTEN Promotes the proliferation of leukemia cells and inhibits their differentiation by enhancing expression of Bcl2, PTEN [128]
 METTL14 GBC Antioncogene ADAM19 Inhibits the stemness of GSCs by promoting the expression of ADAM19 [60, 61]
HCCa Antioncogene miR126 Inhibits the metastasis and relapse of HCC by promoting the mature of tumor suppressor miR126 with the aid of DGCR8 [83]
CRC Antioncogene   Inhibits the proliferation and metastasis of CRC by up-regulating the m6A level of lncRNA XIST and facilitates its degradation [95]
ccRCC Antioncogene NANOG Inhibits the stemness of ccRCC cells by reducing the expression of NANOG [103]
   VHL Inhibits the stemness of ccRCC cells by up-regulating the expression of VHL and reducing the level of HIF-α [103]
BC Antioncogene Notch-1 Inhibits the self-renewal of TICs by reducing the expression of Notch-1 [112]
AML Oncogene MYB MYC Promotes the expression of MYB and MYC [129]
 WTAP HCC Oncogene ETS1 Inhibits the expression of HCC suppressor ETS1 with the help of HuR [79]
ccRCC Oncogene CDK2 Promotes the metastasis by increasing the expression of CDK2 [8]
 VIRMA HCC Oncogene ID2 Promotes the migration by decreasing the expression of ID2 [80]
   GATA3 Promotes decay of GATA3 by inducing the separation of HuR [81]
Prostate cancer Oncogene CCAT1, CCAT2 Enhances malignant phenotype and the translation of lncRNAs CCAT1, CCAT2 [106]
Breast cancer Oncogene CDK1 Enhances the expression of CDK1 [123]
Erasers
 FTO GBC Oncogene ADAM19 Enhances the stemness of GSCs by promoting the expression of ADAM19 [58]
LCa Oncogene LAMC2 TSP1 VGF ITGα11 PCSK9 Enhances the stemness of lung cancer stem cells by promoting expression of LAMC2, TSP1, VGF, ITGα and PCSK9 [67]
HCC Oncogene PK2 Promotes the expression of PK2 by demethylation [82]
Pancreatic cancer Oncogene MYC,bHLH-TF Promotes the proliferation of pancreatic cancer cells by increasing expression of MYC, bHLH-TF [98]
ccRCC Antioncogene ? ? [104]
CC Oncogene ? Enhances the resistance to chemoradiotherapy by inhibiting the translation of β-catenin mRNA [115]
AML Oncogene RARα ASB2 Inhibits differentiation of AML cells and promotes resistant to ATRA by enhancing the expression of RARα and ASB2 [126]
  Oncogene MYC CRBPA Reduces the degradation of MYC and CRBPA in YTHDF2-dependent way [130]
 ALKBH5 GBC Oncogene ADAM19 FOXM1 Enhances the stemness of GSCs by promoting the expression of ADAM19 and FOXM1 [33, 58, 62]
LC Oncogene FOXM1 Enhances the stemness of GSCs by promoting the expression of FOXM1 [33, 62, 69]
GC Oncogene NEAT1 Promotes the metastasis by increasing the expression of NEAT1 [90]
ccRCCa Oncogene NANOG Promotes the stemness of ccRCC cells by increasing the expression of NANOG [103]
   VHL Promotes the stemness of ccRCC cells by silencing VHL and increases the level of HIF-α [103]
  Antioncogene ? ? [104]
CC Antioncogene GAS5 Inhibits the decay of tumor suppressor GAS5 by interacting with lncRNA GAS5-AS1 in YTHDF2-dependent way [114]
Breast cancer Oncogene NANOG Enhances the stemness of BCSCs by promoting expression of NANOG [118, 119]
   KLF4 Enhances the stemness of BCSCs by promoting the expression of KLF4 [119]
AMLa Oncogene TACC3 AXL Promotes self-renewal of LSCs/LICs via ALKBH5/m6A/TACC3 axis and KDM4C/ALKBH5/AXL axis [132, 133]
  Antioncogene TP53 Inhibits the mutation of TP53 [131]
Readers
 YTHDF1 CRC Oncogene ? Promotes the proliferation of CRC cells by activating the Wnt/beta-catenin pathway [96]
BC Oncogene ITGA6 Promotes the translation of ITGA6 by enhancing its stability [111]
EC Antioncogene PHLPP2 Keeps the balance of AKT pathway by promoting the expression of PHLPP2 [116]
 YTHDF2 HCCa Oncogene SOCS2 Facilitates the degradation of tumor suppressor m6A-modified SOCS2 mRNA and down-regulate its expression [76]
  Antioncogene IL11 SERPINE2 Improves the microenvironment by accelerating the degradation of IL11, SERPINE2 [84]
CRC Antioncogene XIST Inhibits the proliferation and metastasis of CRC by facilitating the degradation of m6A-modified lncRNA XIST [95]
Pancreatic cancer Oncogene ? Promotes the progression of EMT by regulating the YAP signaling pathway and inhibits the metastasis of pancreatic cancer [100]
Prostate cancer Oncogene ? Promotes the proliferation of prostate cancer cells and accelerates metastasis by? [107]
CC Oncogene GAS5 Promotes the degradation of tumor suppressor GAS5 [114]
EC Antioncogene mTORC Keeps the balance of AKT pathway by promoting the decay of mTORC [116]
AML Antioncogene MYC CRBPA Accelerates the degradation of MYC CRBPA [130]
 YTHDF3 BC Oncogene ITGA6 Promotes the translation of ITGA6 by enhancing its stability [111]
CRC Oncogene   Facilitates the progression of CRC by the negative function loop of lncRNA GAS5-YAP-YTHDF3 axis [97]
 YTHDC1 GBC Oncogene SRSFs Enhances the stemness of GSCs by promoting the decay of m6A-modified SRSFs mRNA [59]
  Oncogene Snail Promotes the progression of EMT by regulating the expression of Snail [77]
 IGF2BPs HCC Oncogene MYC Promotes the expression of oncogene MYC by enhcancing its stability [51]
GC Oncogene SEC62 Promotes the translation of m6A-modified SEC62 mRNA by enhancing its stability [88]
   HDFG Promotes the translation of m6A-modified HDGF mRNA by enhancing its stability [89]
Pancreatic cancer Oncogene DANCR Enhances the stemness of pancreatic cancer cells by up-regulating the expression of DANCR [99]
 METTL3 LC Oncogene BRD4 Promotes the expression of oncogene BRD4 by interacting with eIF3h [71]
  1. aThere is still some controversy