Table 4 Top 10 cancer associated CpGs
From: Longitudinal study of leukocyte DNA methylation and biomarkers for cancer risk in older adults
|  |  |  | Residual β-value Y6 ttest in HABC3 | Replication in Roos. et al. | Correlation of Y6-Y1 with YTD in HABC5 |
|---|---|---|---|---|---|
ProbeID | Chr (Mb) 1 | Location2 | Canc. yes-no (pval) | Canc. yes-no (pval)4 | R |
cg09608390 | 17(1.00) | exon ABR | 0.019 (1.1E-06) |  | −0.42 (0.41) |
cg01399430 | 5(6.52) | intergenic | −0.048 (5.6E-06) |  | 0.34 (0.50) |
cg02162462 | 2(42.8) | Intron1 MTA3; CGI | −0.027 (1.0E-05) | 0.02 (0.93) | 0.63 (0.18) |
cg25105842 | 2(224.83) | 3’UTR MRPL44 | 0.016 (1.6E-05) | 0.37 (0.08) | 0.09 (0.86) |
cg05808305 | 11(2.77) | intron; KCNQ1 | −0.016 (1.8E-05) |  | 0.30 (0.57) |
cg25403416 | 19(30.19) | 3’UTR; C19orf12 | 0.019 (1.8E-05) | −0.14 (0.30) | −0.06 (0.91) |
cg07516252 | 14(24.64) | promoter REC8; CGI | −0.038 (2.0E-05) | 0.08 (0.37) | 0.89 (0.02) |
cg08129331 | 17(78.56) | Intron1 RPTOR | −0.039 (2.4E-05) | −0.13 (0.05) | 0.83 (0.04) |
cg11784099 | 21(46.23) | Intron1 SUMO3 | 0.035 (2.4E-05) |  | −0.06 (0.91) |
cg04429789 | 1(45.52) | intron ZSWIM5 | 0.024 (2.7E-05) |  | −0.81 (0.05) |
CD8T |  |  | −0.027 (0.02) |  | −0.202 (0.70) |
Gran |  |  | 0.14 (0.04) |  | −0.05 (0.93) |
PC1 |  |  | 17.01 (0.008) |  | −0.21 (0.69) |