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Table 4 Top 10 cancer associated CpGs

From: Longitudinal study of leukocyte DNA methylation and biomarkers for cancer risk in older adults

    Residual β-value Y6 ttest in HABC3 Replication in Roos. et al. Correlation of Y6-Y1 with YTD in HABC5
ProbeID Chr (Mb) 1 Location2 Canc. yes-no (pval) Canc. yes-no (pval)4 R
cg09608390 17(1.00) exon ABR 0.019 (1.1E-06)   −0.42 (0.41)
cg01399430 5(6.52) intergenic −0.048 (5.6E-06)   0.34 (0.50)
cg02162462 2(42.8) Intron1 MTA3; CGI −0.027 (1.0E-05) 0.02 (0.93) 0.63 (0.18)
cg25105842 2(224.83) 3’UTR MRPL44 0.016 (1.6E-05) 0.37 (0.08) 0.09 (0.86)
cg05808305 11(2.77) intron; KCNQ1 −0.016 (1.8E-05)   0.30 (0.57)
cg25403416 19(30.19) 3’UTR; C19orf12 0.019 (1.8E-05) −0.14 (0.30) −0.06 (0.91)
cg07516252 14(24.64) promoter REC8; CGI −0.038 (2.0E-05) 0.08 (0.37) 0.89 (0.02)
cg08129331 17(78.56) Intron1 RPTOR −0.039 (2.4E-05) −0.13 (0.05) 0.83 (0.04)
cg11784099 21(46.23) Intron1 SUMO3 0.035 (2.4E-05)   −0.06 (0.91)
cg04429789 1(45.52) intron ZSWIM5 0.024 (2.7E-05)   −0.81 (0.05)
CD8T    −0.027 (0.02)   −0.202 (0.70)
Gran    0.14 (0.04)   −0.05 (0.93)
PC1    17.01 (0.008)   −0.21 (0.69)
  1. 1GRCh37/hg19
  2. 2CGI is CpG island
  3. 3Mean difference between cancer-present and cancer-free groups of Health ABC at Year 6 and t-test p-values
  4. 4Mean difference between cancer discordant twins in Roos et al. (yes – no) and t-test p-values
  5. 5Mean Correlation between years to diagnosis and longitudinal change in residual β-values (deltaβ = Year 6 – baseline) in cancer group of Health ABC