Fig. 1

DCLK1 serum levels are significantly altered across normal (n = 5), Barrett’s esophagus (n = 9), and esophageal adenocarcinoma before (n = 14) and after treatment (n = 6)(p = 0.0029). Compared to normal controls, DCLK1 serum is increased 67.0% (95% CI: 45.0–89.7%) in stage I-II esophageal adenocarcinoma patients (p = 0.0007) and significantly decreased after treatment by approximately 50% (p = 0.0326). No statistically significant differences were apparent between low-grade (grey points) and high-grade (black points) Barrett’s esophagus