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Fig. 2 | Biomarker Research

Fig. 2

From: The orphan nuclear receptor EAR-2 (NR2F6) inhibits hematopoietic cell differentiation and induces myeloid dysplasia in vivo

Fig. 2

Secondary transplantation of EAR-2 bone marrow chimeras results in acute leukemia. a Survival of secondary transplant recipients (n = 8 GFP and n = 8 EAR-2). Animals that received secondary-transplantation with EAR-2+ BM showed infiltration by leukemia cells in the (b i) bone marrow, (ii) spleen, (iii) liver and (iv) peripheral blood. These effects were even more pronounced in tertiary transplant recipients. (b v) Morphology of the leukemia blast cells is shown. c Survival curve for bone marrow transplant chimera not receiving secondary transplantation. d Immunophenotype of the blast cells is shown

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