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Fig. 1 | Biomarker Research

Fig. 1

From: Dysregulated transcriptional networks in KMT2A- and MLLT10-rearranged T-ALL

Fig. 1

Gene expression profiling for KMT2A-R and MLLT10-R in a cohort of 100 T-ALL samples. Analyses were performed for 330 probe sets related to commonly and exclusively differentially expressed genes in 3 T-ALL groups: KMT2A-R, MLLT10-R and Others (FDR ≤ 0.05) (Additional file 2: Table S1). a Heat map of the top 40 up-regulated and top 10 down-regulated genes in KMT2A-R as compared to cases that do not harbor either KMT2A- or MLLT10-R. The genes were selected out of 307 identified probe sets ranked by FDR ≤0.05 b Heat map indicating 46 probe sets associated with aberrantly deregulated genes in MLLT10-R as compared to cases not harboring these and KMT2A gene lesions. c Differentially expressed genes (27 probe sets) in MLLT10-R versus KMT2A-R. Columns indicate T-ALL samples organized in groups based on presence or absence of genomic lesion of interest. “Others” reflect cases that do not have either KMT2A-R or MLLT10-R. Rows indicate probe sets corresponding to significantly expressed genes. Each row represents the relative expression for a particular gene across the samples within above the mean (red), below the mean (green), and around the mean (black). Vertical bars discriminate between up-regulated (red) and down-regulated (green) genes in given comparable groups

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