Comparative analysis of cerebrospinal fluid metabolites in Alzheimer’s disease and idiopathic normal pressure hydrocephalus in a Japanese cohort

Table 3 Statistically significant metabolites between AD and iNPH in the validation

	Mean concentration, μmol/L (SD)				Welch’s t-test	ROC	AD/iNPH
Metabolite	AD		iNPH		P-value^a	AUC	Fold change
Serine	29.1	(5.3)	34.5	(4.9)	1.6E-04	0.78	0.84
Glycerate	54.6	(22.2)	37.3	(12.9)	2.0E-04	0.71	1.46
3-Methylhistidine	1.1	(0.9)	2.1	(1.2)	6.4E-04	0.82	0.52
Threonine	29.0	(7.0)	39.4	(12.9)	7.4E-04	0.77	0.74
Methionine	2.6	(1.0)	3.6	(1.2)	9.4E-04	0.77	0.71
Urate	19.9	(8.6)	28.7	(9.9)	1.3E-03	0.78	0.70
N-Acetylneuraminate	16.1	(3.9)	12.9	(3.2)	1.9E-03	0.75	1.25
Alanine	33.0	(8.4)	42.4	(12.6)	3.9E-03	0.73	0.78
2-Hydroxybutyrate	17.5	(4.6)	22.2	(6.7)	0.009	0.72	0.79

^aBonferroni correction was applied
AD Alzheimer’s disease, iNPH idiopathic normal pressure hydrocephalus, AUC area under the curve, ROC receiver operator characteristic

ISSN: 2050-7771