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Table 3 Statistically significant metabolites between AD and iNPH in the validation

From: Comparative analysis of cerebrospinal fluid metabolites in Alzheimer’s disease and idiopathic normal pressure hydrocephalus in a Japanese cohort

  Mean concentration, μmol/L (SD) Welch’s t-test ROC AD/iNPH
Metabolite AD iNPH P-valuea AUC Fold change
Serine 29.1 (5.3) 34.5 (4.9) 1.6E-04 0.78 0.84
Glycerate 54.6 (22.2) 37.3 (12.9) 2.0E-04 0.71 1.46
3-Methylhistidine 1.1 (0.9) 2.1 (1.2) 6.4E-04 0.82 0.52
Threonine 29.0 (7.0) 39.4 (12.9) 7.4E-04 0.77 0.74
Methionine 2.6 (1.0) 3.6 (1.2) 9.4E-04 0.77 0.71
Urate 19.9 (8.6) 28.7 (9.9) 1.3E-03 0.78 0.70
N-Acetylneuraminate 16.1 (3.9) 12.9 (3.2) 1.9E-03 0.75 1.25
Alanine 33.0 (8.4) 42.4 (12.6) 3.9E-03 0.73 0.78
2-Hydroxybutyrate 17.5 (4.6) 22.2 (6.7) 0.009 0.72 0.79
  1. aBonferroni correction was applied
  2. AD Alzheimer’s disease, iNPH idiopathic normal pressure hydrocephalus, AUC area under the curve, ROC receiver operator characteristic