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Table 2 Statistically significant metabolites between AD and iNPH in the metabolomics

From: Comparative analysis of cerebrospinal fluid metabolites in Alzheimer’s disease and idiopathic normal pressure hydrocephalus in a Japanese cohort

   Mean concentration, μmol/L (SD) Welch’s t-test ROC AD/iNPH Valid value Missing value
PubChem ID Metabolite AD iNPH P-value AUC Fold change AD iNPH AD iNPH
752 Glycerate 60.61 (30.94) 26.23 (6.22) 6.E-07 0.88 2.31 32 16 7 3
1060 Pyruvate 45.22 (13.45) 68.34 (12.95) 1.E-04 0.89 0.66 12 16 27 3
3441 2-Oxoisopentanoate 4.29 (1.19) 5.64 (1.29) 0.001 0.78 0.76 30 19 9 0
3568 N-Acetylneuraminate 16.75 (3.89) 13.35 (3.2) 0.001 0.76 1.25 39 19 0 0
617 Serine 24.63 (3.9) 30.12 (6.15) 0.002 0.77 0.82 39 19 0 0
273,260 N-Acetylhistidinea 1.19 (0.88) 0.88 (0.92) 0.002 0.72 1.36 39 19 0 0
8180 Undecanoatea 0.54 (0.17) 0.71 (0.09) 0.003 0.81 0.76 17 7 22 12
3,527,278 4-Methyl-2-oxopentanoate 2.64 (0.85) 3.51 (0.98) 0.003 0.74 0.75 39 19 0 0
11,266 2-Hydroxybutyrate 18.08 (5.98) 23.14 (6.06) 0.005 0.74 0.78 39 19 0 0
525 Malate 1.17 (0.33) 1.54 (0.46) 0.005 0.73 0.76 39 19 0 0
602 Alanine 32.03 (8.53) 42.82 (14.42) 0.006 0.77 0.75 39 19 0 0
876 Methionine 2.79 (1.08) 3.67 (1.07) 0.006 0.76 0.76 39 19 0 0
205 Threonine 27.56 (6.43) 34.81 (9.53) 0.006 0.73 0.79 39 19 0 0
232 Arginine 23.08 (4.5) 26.79 (4.6) 0.006 0.71 0.86 39 19 0 0
64,969 3-Methylhistidine 1.12 (0.88) 1.81 (0.92) 0.010 0.79 0.62 39 19 0 0
1081 Citramalate 1.20 (0.96) 0.57 (0.12) 0.010 0.74 2.12 19 8 20 11
1175 Urate 20.84 (11.36) 30.61 (15.74) 0.023 0.73 0.68 39 19 0 0
866 Lysine 30.00 (5.84) 36.35 (10.66) 0.023 0.72 0.82 39 19 0 0
  1. aUndecanoate and N-Acetylhistidine were excluded from further analysis
  2. AD Alzheimer’s disease, iNPH idiopathic normal pressure hydrocephalus, AUC area under the curve, ROC receiver operator characteristic