Fig. 1
From: The drive to generate multiple forms of oncogenic cyclin D1 transcripts in mantle cell lymphoma
The diversity of cyclin D1 transcripts in mantle cell lymphoma. This work is based on a previous publication [5]. a A schematic showing the location and sequences of all the potential polyadenylation signals (PAS) in full length CCND1 mRNA with the canonical polyadenylation signal (AAUAAA) at the most distal terminus. b Schematic of the PAS used in the alternative polyadenylation of the CCND1 in some MCL patients. The underlined letter (in red) is mutated in these patients to generate a canonical PAS. c The unaltered PAS which was identified in the Jeko-1 MCL cell line is shown and it is downstream of the other proximal hexamer. d A diagrammatic representation of the CCND1/MRCK fusion chimera showing the location of the MRCK sequence (in green) in the chimera and the PAS it contains