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Table 2 Relative risk of overall death within 5 years according to clinicopathological factors and expression of PODXL and RBM3

From: Podocalyxin-like and RNA-binding motif protein 3 are prognostic biomarkers in urothelial bladder cancer: a validatory study

  n (events) Univariable P-value Multivariable P-value
HR (95% CI) HR (95% CI)
Entire cohort
 Agea
  Continuous 258 (79) 1.04 (1.01–1.07) 0.010 0.96 (0.59–1.57) 0.875
 Sexa
  Female 79 (23) 1.00   1.00  
  Male 179 (56) 1.06 (0.65–1.72) 0.827 1.03 (1.00–1.06) 0.078
 Gradea
  Low 129 (20) 1.00   1.00  
  High 129 (59) 3.86 (2.32–6.42) <0.001 1.61 (0.82–3.18) 0.165
 Stagea
  Ta 113 (16) 1.00   1.00  
  T1 81 (21) 2.20 (1.14–4.21) 0.018 1.69 (0.81–3.56) 0.165
  T2–T4 64 (42) 8.20 (4.58–14.66) <0.001 4.85 (2.23–10.55) <0.001
 PODXL expression
  Non-membranous 235 (66) 1.00   1.00  
  Membranous 27 (16) 3.28 (1.89–5.69) <0.001 1.49 (0.83–2.68) 0.181
 RBM3 expression
  High 155 (29) 1.00   1.00  
  Low 104 (50) 3.19 (2.02–5.04) <0.001 1.85 (1.11–3.09) 0.018
T1 disease
 Agea
  Continuous 81 (21) 1.01 (0.96–1.07) 0.604 1.08 (1.00–1.17) 0.066
 Sexa
  Female 21 (6) 1.00   1.00  
  Male 60 (15) 1.05 (0.41–2.72) 0.914 0.93 (0.36–2.42) 0.884
 Gradea
  Low 28 (4) 1.00   1.00  
  High 53 (17) 2.17 (0.73–6.47) 0.163 1.63 (0.50–6.84) 0.412
 PODXL expression
  Non-membranous 73 (18) 1.00   1.00  
  Membranous 10 (5) 2.83 (1.04–7.72) 0.042 2.60 (0.91–7.39) 0.073
 RBM3 expression
  High 53 (9) 1.00   1.00  
  Low 28 (12) 2.64 (1.11–6.27) 0.028 2.63 (1.01–6.84) 0.047
T2–T4 disease
 Agea
  Continuous 64 (42) 1.00 (0.96–1.04) 0.935 1.08 (1.00–1.17) 0.066
 Sexa
  Female 18 (12) 1.00   1.00  
  Male 46 (30) 0.77 (0.39–1.52) 0.453 0.93 (0.36–2.42) 0.884
 Gradea
  Low 4 (2) 1.00   1.00  
  High 60 (40) 1.79 (0.43–7.44) 0.424 1.63 (0.51–5.25) 0.412
 PODXL expression
  Non-membranous 47 (31) 1.00   1.00  
  Membranous 17 (11) 1.16 (0.54–2.31) 0.669 1.08 (0.53–2.20) 0.832
 RBM3 expression
  High 18 (9) 1.00   1.00  
  Low 46 (33) 2.01 (0.95–4.23) 0.066 2.22 (0.94–5.28) 0.071
  1. aCases included in the univariable analysis of clinicopathological factors were those that had information on both PODXL and RBM3 expression
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