Podocalyxin-like and RNA-binding motif protein 3 are prognostic biomarkers in urothelial bladder cancer: a validatory study

Boman, Karolina; Andersson, Gustav; Wennersten, Christoffer; Nodin, Björn; Ahlgren, Göran; Jirström, Karin

doi:10.1186/s40364-017-0090-y

Table 2 Relative risk of overall death within 5 years according to clinicopathological factors and expression of PODXL and RBM3

From: Podocalyxin-like and RNA-binding motif protein 3 are prognostic biomarkers in urothelial bladder cancer: a validatory study

	n (events)	Univariable	P-value	Multivariable	P-value
	n (events)	HR (95% CI)	P-value	HR (95% CI)	P-value
Entire cohort
Age^a
Continuous	258 (79)	1.04 (1.01–1.07)	0.010	0.96 (0.59–1.57)	0.875
Sex^a
Female	79 (23)	1.00		1.00
Male	179 (56)	1.06 (0.65–1.72)	0.827	1.03 (1.00–1.06)	0.078
Grade^a
Low	129 (20)	1.00		1.00
High	129 (59)	3.86 (2.32–6.42)	<0.001	1.61 (0.82–3.18)	0.165
Stage^a
Ta	113 (16)	1.00		1.00
T1	81 (21)	2.20 (1.14–4.21)	0.018	1.69 (0.81–3.56)	0.165
T2–T4	64 (42)	8.20 (4.58–14.66)	<0.001	4.85 (2.23–10.55)	<0.001
PODXL expression
Non-membranous	235 (66)	1.00		1.00
Membranous	27 (16)	3.28 (1.89–5.69)	<0.001	1.49 (0.83–2.68)	0.181
RBM3 expression
High	155 (29)	1.00		1.00
Low	104 (50)	3.19 (2.02–5.04)	<0.001	1.85 (1.11–3.09)	0.018
T1 disease
Age^a
Continuous	81 (21)	1.01 (0.96–1.07)	0.604	1.08 (1.00–1.17)	0.066
Sex^a
Female	21 (6)	1.00		1.00
Male	60 (15)	1.05 (0.41–2.72)	0.914	0.93 (0.36–2.42)	0.884
Grade^a
Low	28 (4)	1.00		1.00
High	53 (17)	2.17 (0.73–6.47)	0.163	1.63 (0.50–6.84)	0.412
PODXL expression
Non-membranous	73 (18)	1.00		1.00
Membranous	10 (5)	2.83 (1.04–7.72)	0.042	2.60 (0.91–7.39)	0.073
RBM3 expression
High	53 (9)	1.00		1.00
Low	28 (12)	2.64 (1.11–6.27)	0.028	2.63 (1.01–6.84)	0.047
T2–T4 disease
Age^a
Continuous	64 (42)	1.00 (0.96–1.04)	0.935	1.08 (1.00–1.17)	0.066
Sex^a
Female	18 (12)	1.00		1.00
Male	46 (30)	0.77 (0.39–1.52)	0.453	0.93 (0.36–2.42)	0.884
Grade^a
Low	4 (2)	1.00		1.00
High	60 (40)	1.79 (0.43–7.44)	0.424	1.63 (0.51–5.25)	0.412
PODXL expression
Non-membranous	47 (31)	1.00		1.00
Membranous	17 (11)	1.16 (0.54–2.31)	0.669	1.08 (0.53–2.20)	0.832
RBM3 expression
High	18 (9)	1.00		1.00
Low	46 (33)	2.01 (0.95–4.23)	0.066	2.22 (0.94–5.28)	0.071

^aCases included in the univariable analysis of clinicopathological factors were those that had information on both PODXL and RBM3 expression

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