Fig. 1

Schematic diagram summarizing functional relevance of metastatic signals in synovial sarcoma. SYT-SSX fusion is a founding event in the development of this cancer which frequently results in the production of molecular signals that promote tumor metastasis. Abbreviations: Akt (Serine/threonine kinase); CDCA2 (Cell division cycle A2); CXCR (Chemokine receptor); ERK1/2 (Extracellular signal-regulated kinase 1/2); EZH2 (Enhancer of zeste homologue 2); IGFBP7 (Insulin-like growth factor-binding protein-7); IGR (Insulin like growth factor receptor); KIF14 (Kinesin family member 14); MAPK (Mitogen-activated protein kinases); MicroRNAs (miRNAs); MMPs (Matrix metalloproteinases); mTOR (Mammalian target of rapamycin); NY-ESO-1 (New York esophageal squamous cell carcinoma 1); PI3K (Phosphatidylinositol-3-kinase); pri-miRNA (primary microRNA); pre-miRNA (precursor microRNA); PKB (Protein kinase B); RAS (Ras GTPase); SCRN1 (Secernin-1); TGF-β (Transforming growth factor beta); TβR (TGF-beta receptor); TF (transcription factor)