Table 3 Surface modification of dental implants with peptides

Germanier et al. [40]

Pig – maxilla

1. SLA (control)

2. SLA + PLL-g-PEG

3. SLA + PLL-g-PEG/PEG-RDG

4. SLA + PLL-g-PEG/PEG-RGD

2 and 4 weeks

% of BIC

- SLA: 43.6% at 2 weeks, 62.5% at 4 weeks

- SLA + PLL-g-PEG: 55.9% at 2 weeks, 67.4% at 4 weeks

- SLA + PLL-g-PEG/PEG-RDG: 48.5% at 2 weeks, 75.5% at 4 weeks

- SLA + PLL-g-PEG/PEG-RGD: 61.7% at 2 weeks, 62.5% at 4 weeks

Barros et al. [41]

Dog – mandible

1. A: microstructured + HA + low concentrated (20 μg/ml) peptide

2. B: microstructured + HA

3. C: microstructured

4. D: microstructured + HA + high concentrated (200 μg/ml) peptide

12 weeks

% of BIC

- A: 60.4%

- B: 62.4%

- C: 58.0%

- D: 65.4%

BD

- A: 54.7%

- B: 46.0%

- C: 45.3%

- D: 40.7%

Yang et al. [42]

Rabbit – femur and tibia

1. Control: uncoated

2. RGD-coated

4, 8, and 12 weeks

% of BIC

- Control: 50.2%, 58.5%, and 60.9% at 4, 8, and 12 weeks, respectively

- RGD-coated: 70.0%, 74.9%, and 82.2% at 4, 8, and 12 weeks, respectively

Lutz et al. [43]

Pig – forehead

1. Group A: HA

2. Group B: HA + P-15 (20 μg/ml)

3. Group C: HA + P-15 (200 μg/ml)

14 and 30 days

% of BIC for ROI A and ROI B, respectively

- A: 63.8 & 76.7% at 14 days, 70.9 & 75.8% at 30 days

- B: 72.1 & 72.5% at 14 days, 69.9 & 74.6% at 30 days

- C: 88.2 & 88.7% at 14 days, 80.5 & 88.5% at 30 days

BD for ROI A and ROI B, respectively

- A: 49.5 & 36.2% at 14 days, 38.4 & 28.7% at 30 days

- B: 44.0 & 31.6% at 14 days, 45.7 & 42.9% at 30 days

- C: 44.9 & 36.1% at 14 days, 47.2 & 44.5% at 30 days

Yoo et al. [44]

Rabbit - tibia

1. Anodized Ti implant (control)

2. PLGA/rhBMP-2 coated

3 and 7 weeks

% of BIC (total)

- Control: 27.26% at 3 weeks; 31.47% at 7 weeks

- PLGA/rhBMP-2: 34.69% at 3 weeks; 35.32% at 7 weeks