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Table 1 Prognostic scoring formulas to determine severity of acute alcoholic hepatitis

From: Prognostic models for alcoholic hepatitis

Scoring system Formula Severe Disease
mDF 4.6 (patient’s PT in seconds- control PT in seconds) + total bilirubin (mg/dL) ≥32  
CTP 1 2 3   
 Bilirubin <2 mg/dL 2–3 mg/dL >3 mg/dL Class A 5–6 points
 Albumin >3.5 g/dL 2.8–3.5 g/dL <2.8 g/dL Class B 7–9 points
 INR <1.7 1.7–2.2 >2.2 Class C 10–15 points
 Ascites None Mild Severe  
 Encephalopathy None Grade I-II Grade III-IV  
MELD MELD Score = 0.957 x Loge (creatinine mg/dL) + 0.378 x Loge (bilirubin mg/dL) + 1.120 x Loge (INR) 0.6431* 10 (if hemodialysis, value for Creatinine is automatically set to 4.0) MELD ≥ 21
MELD score = 3.8*loge (total bilirubin, mg/dL) + 11.2*loge (INR) + 9.6*loge(creatinine, mg/dL)  
MELD score = 9.57 x loge (Cr mg/dL) + 3.78 x loge (bili mg/dL) + 11.20 x loge (INR) + 6.43  
MELD-Na MELD-Na score = MELD Score - Na - 0.025*MELD* (140-Na) + 140  
GAHS 1 2 3 ≥9
 Age <50 ≥50 -  
 WBC (109/l) <15 ≥15 -  
 Urea (mmol/l) <5 ≥5 -  
 PT ratio <1.5 1.5–2.0 >2.0  
 Bilirubin (μmol/l) <125 125 - 250 >250  
Lille Score Lille Score = 3.19–0.101 * (age in years) + 0.147 * (albumin day 0 in g/L) + 0.0165 * (evolution in bilirubin level in μM) - (0.206 * renal insufficiency) - 0.0065 * (bilirubin day 0 in μM) - 0.0096 * (INR or prothrombin time in seconds). ≥0.45
ABIC score ABIC score = (age × 0.1) + (serum bilirubin × 0.08) + (serum creatinine × 0.3) + (INR × 0.8) >9.0
AHHS   Points  
Stage of fibrosis   Mild (0–3)
No fibrosis or portal fibrosis 0 Moderate (4–5)
Expansive fibrosis 0 Severe (6–9)
Bridging fibrosis or cirrhosis 3
Bilirubinostasis  
No 0
Hepatocellular only 0
Canalicular or ductular 1
Canalicular or ductular plus hepatocellular 2
PMN infiltration  
No/ Mild 2
Severe 0
Megamitochondria  
No Megamitochondria 2
Megamitochondria 0
  1. mDF modified Discriminant Function, CTP Child Turcotte Pugh, MELD Model for End-stage Liver Disease, GAHS Glasgow Alcoholic Hepatitis Score, ABIC Age serum Bilirubin INR and serum Creatinine, AHHS Alcoholic Hepatitis Histologic Score