Figure 3

Schematic model of signaling pathways implicated in glioma vasculogenic mimicry (VM). The whole VM process proceeds under the condition of hypoxia. Only signaling molecules which have been specifically modulated using small inhibitory RNAs, blocking antibodies or small molecule inhibitors are depicted -- demonstrating their ability to directly or indirectly affect VM, and are categorized as microenvironment (purple), embryonic/stem cell (red), and hypoxia signaling pathways (blue). There are no specific boundary lines between the three parts and overlap between major VM signaling pathways demonstrated coordinated work of these pathways.