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Figure 1 | Biomarker Research

Figure 1

From: Pan-cancer analysis of genomic scar signatures associated with homologous recombination deficiency suggests novel indications for existing cancer drugs

Figure 1

Overview of the type of genomic scars measured by each HR signature. Dark and light grey are used to indicate paternal and maternal chromosomes. A: Number of telomeric allelic imbalances (NtAI) counts the number of subtelomeric regions with allelic imbalance, that start beyond the centromere and extend to the telomere. B: Large-scale state transitions (LST) counts the number of chromosomal breaks between adjacent regions of at least 10 Mb. C: Homologous recombination deficiency score (HRD-LOH) measures the number of regions with LOH which are larger than 15 Mb, but shorter than the whole chromosome.

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Biomarker Research

ISSN: 2050-7771

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