Table 6 FISH probes that are commonly used for clinical diagnosis of solid tumors
Probes | Cytogenetic anomaly | Associated disorder |
|---|---|---|
CEP3,7,17; p16 | Chromosome 3, 7, 17 aneuploidy; 9p21 | Bladder carcinoma |
HER-2/CEP17 | 17q11.2-q12 | Breast cancer |
TOP2A | 17q21-22 | Breast cancer |
TERC/CEP3 | 3q26.3 | Cervical cancer |
EWSR1 | 22q12 | Ewing sarcoma |
EGFR | 7p12 | NSCLC |
ALK | 2p23 | NSCLC |
ROS1 | 6p22 | NSCLC |
TMPRSS2/ETV1 | 21q22.3/7p21.1 | Prostate cancer |
TMPRSS2/ETV4 | 21q22.3/17q21.3 | Prostate cancer |
ERG | 21q22.2 | Prostate cancer |