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Table 6 FISH probes that are commonly used for clinical diagnosis of solid tumors

From: Fluorescence in situ hybridization (FISH): an increasingly demanded tool for biomarker research and personalized medicine

Probes Cytogenetic anomaly Associated disorder
CEP3,7,17; p16 Chromosome 3, 7, 17 aneuploidy; 9p21 Bladder carcinoma
HER-2/CEP17 17q11.2-q12 Breast cancer
TOP2A 17q21-22 Breast cancer
TERC/CEP3 3q26.3 Cervical cancer
EWSR1 22q12 Ewing sarcoma
EGFR 7p12 NSCLC
ALK 2p23 NSCLC
ROS1 6p22 NSCLC
TMPRSS2/ETV1 21q22.3/7p21.1 Prostate cancer
TMPRSS2/ETV4 21q22.3/17q21.3 Prostate cancer
ERG 21q22.2 Prostate cancer