Table 2 Accuracy of diagnostic panels for advanced liver fibrosis

Angulo [61]

age≥45 years, obesity (BMI>31.1 for male,

144

n/a

n/a

n/a

n/a

n/a

n/a

>32.3 for female), diabetes, AAR>1

Ratziu [62]

BAAT score

93

0.84

0

100

11

33

100

(BMI≥28 kg/m², age≥50 years, ALT≥2xULN,

1

100

47

45

100

triglycerides≥1.7 mmol/L)

2

71

80

61

86

3

14

100

100

73

4

0

100

0

70

Rosenberg

Original European Liver Fibrosis panel

61

0.87

0.375

89

96

80

98

[63]

(age, HA, TIMP1, PIIINP)

0.462

78

98

87

96

Guha [64]

Enhanced Liver Fibrosis panel

192

0.90

0.3576

80

90

71

94

(HA, TIMP1, PIIINP)

Gholam [51]

ALT, HbA1C

97

0.90

6.6

83

82

n/a

n/a

Ratziu [65]

FibroTest

267

0.81

0.3

77

77

54

90

(α2 macroglobulin, haptoglobin, GGT,

0.7

15

98

73

76

Total bilirubin, apolipoprotein A1)

Angulo [66]

NAFLD Fibrosis Score

733

0.84

<−1.455^†

82

77

56

93

(age, hyperglycemia, BMI, platelet count,

>0.676^†

51

98

90

85

albumin, AAR)

<−1.455^¥

77

71

52

88

>0.676^¥

43

96

82

80

Harrison [67]

BARD score

827

0.81

2-4

43

96

(BMI≥28 kg/m², AAR≥0.8, diabetes)

Cales [68]

Fibrometer NAFLD

235

0.943

78.5

95.9

87.9

92.1

(glucose, AST, ferritin, ALT, body weight,

age)

Shah [69]

FIB4 index

541

0.802

<1.30

74

71

43

90

(age, ALT, AST, platelet count)

>2.67

33

98

80

83

Sumida [59]

NAFIC score

619

0.834

0

95

33

32

96

[serum ferritin (≥200 ng/mL for female,

2-4

84

74

52

93

≥300 ng/mL for male), fasting insulin≥10

μU/mL, type IV collagen 7S≥5 ng/mL]

Younossi [60]

NAFLD Diagnostic Panel

79

0.80

0.2188

90.91

43.59

57.7

85

(diabetes, gender, BMI, triglycerides,

0.4242

60.61

71.79

64.5

68.3

apoptotic and necrotic CK18 fragments)

0.5689

51.52

89.74

81

68.6