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Table 2 Accuracy of diagnostic panels for advanced liver fibrosis

From: Noninvasive biomarkers for the diagnosis of steatohepatitis and advanced fibrosis in NAFLD

Reference Biomarkers N AUROC Cutoff value Se (%) Sp (%) PPV (%) NPV (%)
Angulo [61] age≥45 years, obesity (BMI>31.1 for male, 144 n/a n/a n/a n/a n/a n/a
  >32.3 for female), diabetes, AAR>1        
Ratziu [62] BAAT score 93 0.84 0 100 11 33 100
  (BMI≥28 kg/m2, age≥50 years, ALT≥2xULN,    1 100 47 45 100
  triglycerides≥1.7 mmol/L)    2 71 80 61 86
     3 14 100 100 73
     4 0 100 0 70
Rosenberg Original European Liver Fibrosis panel 61 0.87 0.375 89 96 80 98
[63] (age, HA, TIMP1, PIIINP)    0.462 78 98 87 96
Guha [64] Enhanced Liver Fibrosis panel 192 0.90 0.3576 80 90 71 94
  (HA, TIMP1, PIIINP)        
Gholam [51] ALT, HbA1C 97 0.90 6.6 83 82 n/a n/a
Ratziu [65] FibroTest 267 0.81 0.3 77 77 54 90
  (α2 macroglobulin, haptoglobin, GGT,    0.7 15 98 73 76
  Total bilirubin, apolipoprotein A1)        
Angulo [66] NAFLD Fibrosis Score 733 0.84 <−1.455 82 77 56 93
  (age, hyperglycemia, BMI, platelet count,    >0.676 51 98 90 85
  albumin, AAR)    <−1.455¥ 77 71 52 88
     >0.676¥ 43 96 82 80
Harrison [67] BARD score 827 0.81 2-4    43 96
  (BMI≥28 kg/m2, AAR≥0.8, diabetes)        
Cales [68] Fibrometer NAFLD 235 0.943   78.5 95.9 87.9 92.1
  (glucose, AST, ferritin, ALT, body weight,        
  age)        
Shah [69] FIB4 index 541 0.802 <1.30 74 71 43 90
  (age, ALT, AST, platelet count)    >2.67 33 98 80 83
Sumida [59] NAFIC score 619 0.834 0 95 33 32 96
  [serum ferritin (≥200 ng/mL for female,    2-4 84 74 52 93
  ≥300 ng/mL for male), fasting insulin≥10        
  μU/mL, type IV collagen 7S≥5 ng/mL]        
Younossi [60] NAFLD Diagnostic Panel 79 0.80 0.2188 90.91 43.59 57.7 85
  (diabetes, gender, BMI, triglycerides,    0.4242 60.61 71.79 64.5 68.3
  apoptotic and necrotic CK18 fragments)    0.5689 51.52 89.74 81 68.6
  1. AUROC, area under receiver operator characteristic curve; Se, sensitivity; Sp, specificity; PPV, positive predictive value; NPV, negative predictive value; ALT, alanine aminotransferase; AST, aspartate aminotransferase; BMI, body mass index; AAR, AST/ALT ratio; HA, hyaluronic acid; GGT, gamma-glutamyl transpeptidase; TIMP1, tissue inhibitor of metalloproteinase 1; PIIINP, amino-terminal propeptide of type III collagen; ULN, upper limit of normal; n/a, not available.
  2. Estimation group; ¥Validation group.