Fig. 1

Expression and clinical significance of DAB2 in GC. A Schematic illustration of strategies for screening the key genes involved in H pylori infection-driven gastric tumorigenesis. Gene Expression Omnibus and TCGA datasets were used to determine the upregulated genes in GC tissues (T) compared with nontumor (NT) tissues. TCGA and ACRG cohorts were uesd to determine the upregulated genes that correlated with H pylori infection (HP cohort). B Immunohistochemistry (IHC) analysis shows the expression of DAB2 in normal and human gastric cancer tissue samples (upper panels: magnification ×100; lower panels: magnification ×400). C Quantification scores of DAB2 in GC are shown. D-E The expression levels of DAB2 in different stages of GC in our cohort (**P < 0.01) (D) and TCGA (E) database. F GC tissues were stained with DAB2 and Ki-67 by IHC. Spearman’s rank correlation analysis was used to evaluate the correlation between DAB2 and Ki67 expression (right). Scale bar, 100 μm. G-H Kaplan-Meier survival curve demonstrates an association between high expression of DAB2 and poor overall survival (OS) and disease-free survival (DFS) in overall GC (G) patients and intestinal-type GC (H). HR, hazard ratio. I IF analysis shows the expression of DAB2 in patients with atrophic gastritis, intestinal metaplasia, and dysplasia (magnification ×200). Quantification scores are shown on the right panel