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  1. Review

    Engineering CAR-T cells

    Chimeric antigen receptor redirected T cells (CAR-T cells) have achieved inspiring outcomes in patients with B cell malignancies, and are now being investigated in other hematologic malignancies and solid tumo...

    Cheng Zhang, Jun Liu, Jiang F. Zhong and Xi Zhang

    Biomarker Research 2017 5:22

    Published on: 24 June 2017

  2. Research

    Higher serum concentrations of vimentin and DAKP1 are associated with aggressive breast tumour phenotypes in Ghanaian women

    Breast cancer, the most commonly diagnosed cancer among women and leading cause of cancer-related deaths worldwide, exhibits aggressive behavior in indigenous African women evidenced by high histologic grade t...

    Benjamin Arko-Boham, Justice Tanihu Lomotey, Emmanuel Nomo Tetteh, Emmanuel Ayitey Tagoe, Nii Ayite Aryee, Ewurama Ampadu Owusu, Isaac Okai, Richard Michael Blay and Joe-Nat Clegg-Lamptey

    Biomarker Research 2017 5:21

    Published on: 9 June 2017

  3. Research

    Circulating tumor cell clusters-associated gene plakoglobin is a significant prognostic predictor in patients with breast cancer

    Circulating tumor cells (CTCs) are linked to metastatic relapse and are regarded as a prognostic marker for human cancer. High expression of plakoglobin, a cell adhesion protein, within the primary tumor is po...

    Wataru Goto, Shinichiro Kashiwagi, Yuka Asano, Koji Takada, Katsuyuki Takahashi, Takaharu Hatano, Tsutomu Takashima, Shuhei Tomita, Hisashi Motomura, Masahiko Ohsawa, Kosei Hirakawa and Masaichi Ohira

    Biomarker Research 2017 5:19

    Published on: 12 May 2017

  4. Short report

    Clinical significance of intronic variants in BRAF inhibitor resistant melanomas with altered BRAF transcript splicing

    Alternate BRAF splicing is the most common mechanism of acquired resistance to BRAF inhibitor treatment in melanoma. Recently, alternate BRAF exon 4–8 splicing was shown to involve an intronic mutation, locate...

    Gulietta M. Pupo, Suzanah C. Boyd, Carina Fung, Matteo S. Carlino, Alexander M. Menzies, Bernadette Pedersen, Peter Johansson, Nicholas K. Hayward, Richard F. Kefford, Richard A. Scolyer, Georgina V. Long and Helen Rizos

    Biomarker Research 2017 5:17

    Published on: 11 May 2017

  5. Case report

    Autoimmune hemolytic anemia associated with babesiosis

    Babesiosis is endemic in selected areas in North America. Babesia infection is commonly associated with anemia, thrombocytopenia, hyponatremia and elevated liver enzymes. Autoimmune hemolytic anemia (AIHA) is ...

    Roshni Narurkar, Aleksandra Mamorska-Dyga, John C. Nelson and Delong Liu

    Biomarker Research 2017 5:14

    Published on: 8 April 2017

  6. Case series

    Length of hospitalization is associated with selected biomarkers (albumin and lymphocytes) and with co-morbidities: study on 4000 patients

    Low albumin levels and low lymphocyte counts are intra hospital conditions that exert a negative influence on prognosis, healing and length of hospitalization. The study aimed to analyze the correlation betwee...

    Antonio E. Pontiroli, Lara Loreggian, Marco P. L. Rovati, Elena De Patto, Laura Folini, Federico Raveglia, Matilde De Simone, Alessandro Baisi and Ugo Cioffi

    Biomarker Research 2017 5:13

    Published on: 21 March 2017

  7. Research

    Podocalyxin-like and RNA-binding motif protein 3 are prognostic biomarkers in urothelial bladder cancer: a validatory study

    Urothelial bladder cancer (UBC) is a disease that often is discovered when the tumour is non-muscle invasive, i.e. in Ta or T1 stage. Some patients will progress into muscle-invasive disease, a potentially dea...

    Karolina Boman, Gustav Andersson, Christoffer Wennersten, Björn Nodin, Göran Ahlgren and Karin Jirström

    Biomarker Research 2017 5:10

    Published on: 14 March 2017

  8. Research

    Application of penalized linear regression methods to the selection of environmental enteropathy biomarkers

    Environmental Enteropathy (EE) is a subclinical condition caused by constant fecal-oral contamination and resulting in blunting of intestinal villi and intestinal inflammation. Of primary interest in the clini...

    Miao Lu, Jianhui Zhou, Caitlin Naylor, Beth D. Kirkpatrick, Rashidul Haque, William A. Petri and Jennie Z. Ma

    Biomarker Research 2017 5:9

    Published on: 9 March 2017

  9. Research

    Tissue MicroRNA profiles as diagnostic and prognostic biomarkers in patients with resectable pancreatic ductal adenocarcinoma and periampullary cancers

    The aim of this study was to validate previously described diagnostic and prognostic microRNA expression profiles in tissue samples from patients with pancreatic cancer and other periampullary cancers.

    Dan Calatayud, Christian Dehlendorff, Mogens K. Boisen, Jane Preuss Hasselby, Nicolai Aagaard Schultz, Jens Werner, Heike Immervoll, Anders Molven, Carsten Palnæs Hansen and Julia S. Johansen

    Biomarker Research 2017 5:8

    Published on: 21 February 2017

  10. Case Report

    A case report of concurrent embryonal rhabdomyosarcoma and diffuse large B-cell lymphoma in an adult without identifiable cancer predisposition

    Diffuse large B-cell lymphoma (DLBCL) is the most common form of non-Hodgkin lymphoma. Rhabdomyosarcoma, the most common soft tissue sarcoma of childhood. makes up less than 1% of solid malignancies in adults ...

    M. D. Mathias, M. V. Ortiz, H. Magnan, S. R. Ambati, E. K. Slotkin, A. J. Chou, M. F. Walsh, K. Offit, C. Moskowitz, A. Kentsis and L. H. Wexler

    Biomarker Research 2017 5:7

    Published on: 8 February 2017

  11. Review

    Diagnosis and treatment of CD20 negative B cell lymphomas

    CD20 negative B cell non-Hodgkin lymphoma (NHL) is rare and accounts for approximately 1-2% of B cell lymphomas. CD20- negative NHL is frequently associated with extranodal involvement, atypical morphology, ag...

    Tasleem Katchi and Delong Liu

    Biomarker Research 2017 5:5

    Published on: 7 February 2017

  12. Review

    Metastatic biomarkers in synovial sarcoma

    Synovial sarcoma (SS) is an aggressive soft tissue sarcoma (STS) that typically occurs in the extremities near a joint. Metastatic disease is common and usually occurs in the lungs and lymph nodes. Surgical ma...

    Rosalia de Necochea-Campion, Lee M. Zuckerman, Hamid R. Mirshahidi, Shahrzad Khosrowpour, Chien-Shing Chen and Saied Mirshahidi

    Biomarker Research 2017 5:4

    Published on: 7 February 2017

  13. Research

    NOS1-, NOS3-, PIK3CA-, and MAPK-pathways in skin following radiation therapy

    Essential molecular pathways such as the MAPK pathway, NO system, or the influence of PIK3CA as an oncogene are known to regulate fundamental signalling networks. However, few knowledge about their role in the...

    Steffen Koerdt, Nadine Tanner, Niklas Rommel, Nils H. Rohleder, Gesche Frohwitter, Oliver Ristow, Klaus-Dietrich Wolff and Marco R. Kesting

    Biomarker Research 2017 5:3

    Published on: 20 January 2017

  14. Review

    DNA methyltransferases and their roles in tumorigenesis

    DNA methylation plays an important role in gene expression, chromatin stability, and genetic imprinting. In mammals, DNA methylation patterns are written and regulated by DNA methyltransferases (DNMTs), includ...

    Wu Zhang and Jie Xu

    Biomarker Research 2017 5:1

    Published on: 20 January 2017

  15. Methodology

    Development and validation of a novel bioassay to determine glucocorticoid sensitivity

    Glucocorticoids (GCs) remain the first line treatment for almost all non-infectious inflammatory diseases, ranging from acute asthma to rheumatoid arthritis. However, across all conditions, patients have a var...

    Emily L. Williams, Madeleine L. Stimpson, Peter L. Collins, Doyo G. Enki, Ashish Sinha, Richard W. Lee and Ashwin D. Dhanda

    Biomarker Research 2016 4:26

    Published on: 15 December 2016

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