Fig. 4

Evaluation of diagnostic efficacy by exosomal miRNA combination. Receiver operating characteristics (ROC) were performed on individual and combinatorial sets of 7 miRNAs validated in healthy individuals and patients with small cell lung cancer (SCLC). (A) Area under the ROC curve (AUC) in individual miRNAs and combination sets. ROC curves for classifying serum-derived exosomes were produced using each miRNA expression value for (B) miR-3656; (C) miR-200b-3p; (D) miR-3124-5p; (E) miR-3126-3p; (F) miR-6515-5p; (G) miR-9-5p, and (H) miR-92b-5p separately, and for (I) miR-200b-3p, miR-3124-5p and miR-92b-5p combined. The ROC curve for the miRNA sets were generated based on the predicted probability for each patient. *p < 0.05; **p < 0.005; ***p < 0.0005