Fig. 3

Validation of differentially expressed exosomal miRNAs. Quantitative real-time PCR was performed using serum-derived exosomes from 28 LD-small cell lung cancer (SCLC), 48 ED-SCLC, and 50 healthy participants. (A) Expression levels of has-miR-3656; (B) has-miR-2124-5p; (C) has-miR-200b-3p; (D) has-miR-6515; (E) has-miR-3126-3p; (F) has-miR-9-5p, and (G) has-miR92b-5p. The data were analyzed using Brown–Forsythe and Welch ANOVA with Dunnett’s T3 multiple comparison, comparing each experimental condition with the control. Let-7a-5p was used as an internal control. Data are mean ± SDs; *p < 0.05; **p < 0.005; ***p < 0.0005