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Fig. 6 | Biomarker Research

Fig. 6

From: Elevated ZNF704 expression is associated with poor prognosis of uveal melanoma and promotes cancer cell growth by regulating AKT/mTOR signaling

Fig. 6

Downstream targets of ZNF704 in UM. A Total RNA was isolated from shCtrl and shZNF704 cells and subjected to RNA sequencing analysis. Heatmap of dys-regulated genes. B and C GSEA showed that apoptosis and P53 signaling pathway was correlated with ZNF704 expression. D-F GESA showed that AKT, mTOR and glycolysis were activated in UM samples with ZNF704 high expression. G Immunoblotting analysis of AKT/mTOR/glycolysis in ZNF704 knockdown and over-expressed UM cells

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Biomarker Research

ISSN: 2050-7771

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