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Table 3 Univariate and multivariate analysis with respect to distant metastasis-free survival in 121 patients with breast cancer

From: Circulating tumor cell clusters-associated gene plakoglobin is a significant prognostic predictor in patients with breast cancer

Parameter

 

Univariable analysis

Multivariable analysis

Hazard ratio

95% CI

p value

Hazard ratio

95% CI

p value

Intrinsic subtype

TNBC vs non-TNBC

1.053

0.281–3.344

0.933

0.632

0.137–2.710

0.535

Intrinsic subtype

HER2 vs non-HER2

2.060

0.543–13.41

0.314

1.721

0.353–12.53

0.517

Age at operation

≤56 vs >56

6.096

1.606–39.67

0.006

6.543

1.563–47.40

0.008

Tumor size (cm)

≤2 vs >2

3.234

0.445–40.56

0.049

2.811

0.874–46.08

0.062

Lymph node status

Negative vs Positive

4.493

0.873–82.10

0.077

7.035

1.195–137.4

0.028

Nuclear grade

1–2 vs 3

1.805

0.482–5.730

0.353

12.79

1.591–163.3

0.016

Ki67 (%)

≤14 vs >14

2.048

0.652–6.942

0.218

13.99

2.063–203.4

0.005

Pathological response

pCR vs non-pCR

2.075

0.619–9.357

0.248

1.561

0.301–10.34

0.609

plakoglobin

High vs Low

3.719

1.100–11.66

0.036

7.371

1.596–44.23

0.011

E-cadherin

Low vs High

2.223

0.709–7.517

0.169

5.003

0.966–35.14

0.055

  1. HER2 human epidermal growth factor receptor 2; CI confidence interval; pCR pathological complete response; TNBC triple-negative breast cancer
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Biomarker Research

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