Table 2 Relative risk of overall death within 5 years according to clinicopathological factors and expression of PODXL and RBM3
n (events) | Univariable | P-value | Multivariable | P-value | |
|---|---|---|---|---|---|
HR (95% CI) | HR (95% CI) | ||||
Entire cohort | |||||
Agea | |||||
Continuous | 258 (79) | 1.04 (1.01–1.07) | 0.010 | 0.96 (0.59–1.57) | 0.875 |
Sexa | |||||
Female | 79 (23) | 1.00 | 1.00 | ||
Male | 179 (56) | 1.06 (0.65–1.72) | 0.827 | 1.03 (1.00–1.06) | 0.078 |
Gradea | |||||
Low | 129 (20) | 1.00 | 1.00 | ||
High | 129 (59) | 3.86 (2.32–6.42) | <0.001 | 1.61 (0.82–3.18) | 0.165 |
Stagea | |||||
Ta | 113 (16) | 1.00 | 1.00 | ||
T1 | 81 (21) | 2.20 (1.14–4.21) | 0.018 | 1.69 (0.81–3.56) | 0.165 |
T2–T4 | 64 (42) | 8.20 (4.58–14.66) | <0.001 | 4.85 (2.23–10.55) | <0.001 |
PODXL expression | |||||
Non-membranous | 235 (66) | 1.00 | 1.00 | ||
Membranous | 27 (16) | 3.28 (1.89–5.69) | <0.001 | 1.49 (0.83–2.68) | 0.181 |
RBM3 expression | |||||
High | 155 (29) | 1.00 | 1.00 | ||
Low | 104 (50) | 3.19 (2.02–5.04) | <0.001 | 1.85 (1.11–3.09) | 0.018 |
T1 disease | |||||
Agea | |||||
Continuous | 81 (21) | 1.01 (0.96–1.07) | 0.604 | 1.08 (1.00–1.17) | 0.066 |
Sexa | |||||
Female | 21 (6) | 1.00 | 1.00 | ||
Male | 60 (15) | 1.05 (0.41–2.72) | 0.914 | 0.93 (0.36–2.42) | 0.884 |
Gradea | |||||
Low | 28 (4) | 1.00 | 1.00 | ||
High | 53 (17) | 2.17 (0.73–6.47) | 0.163 | 1.63 (0.50–6.84) | 0.412 |
PODXL expression | |||||
Non-membranous | 73 (18) | 1.00 | 1.00 | ||
Membranous | 10 (5) | 2.83 (1.04–7.72) | 0.042 | 2.60 (0.91–7.39) | 0.073 |
RBM3 expression | |||||
High | 53 (9) | 1.00 | 1.00 | ||
Low | 28 (12) | 2.64 (1.11–6.27) | 0.028 | 2.63 (1.01–6.84) | 0.047 |
T2–T4 disease | |||||
Agea | |||||
Continuous | 64 (42) | 1.00 (0.96–1.04) | 0.935 | 1.08 (1.00–1.17) | 0.066 |
Sexa | |||||
Female | 18 (12) | 1.00 | 1.00 | ||
Male | 46 (30) | 0.77 (0.39–1.52) | 0.453 | 0.93 (0.36–2.42) | 0.884 |
Gradea | |||||
Low | 4 (2) | 1.00 | 1.00 | ||
High | 60 (40) | 1.79 (0.43–7.44) | 0.424 | 1.63 (0.51–5.25) | 0.412 |
PODXL expression | |||||
Non-membranous | 47 (31) | 1.00 | 1.00 | ||
Membranous | 17 (11) | 1.16 (0.54–2.31) | 0.669 | 1.08 (0.53–2.20) | 0.832 |
RBM3 expression | |||||
High | 18 (9) | 1.00 | 1.00 | ||
Low | 46 (33) | 2.01 (0.95–4.23) | 0.066 | 2.22 (0.94–5.28) | 0.071 |