Plasma microRNA biomarker detection for mild cognitive impairment using differential correlation analysis

Biomarker Research

Table 4 Summary of the top 10 two-pairs of miRNAs out of the 20 miRNA pairs detected by differential correlation analysis in Table 3. The two-pairs of miRNAs are ranked by AUC value

Rank	AUC	Original	Original	Two-pairs of miRNAs		Correlation	Coefficients
		Rank*	AUC*			Normal (r ₁)	MCI (r ₂)
1	0.962	14	0.871	hsa-miR-101	hsa-miR-191	0.822	-0.009
		15	0.745	hsa-miR-103	hsa-miR-222	0.622	-0.207
2	0.959	5	0.867	hsa-miR-192	hsa-miR-197	-0.281	0.631
		14	0.871	hsa-miR-101	hsa-miR-191	0.822	-0.009
3	0.958	6	0.854	hsa-miR-191	hsa-miR-19b	0.826	-0.085
		17	0.786	hsa-miR-103	hsa-miR-223	0.840	0.025
4	0.957	1	0.880	hsa-miR-191	hsa-miR-590-5p	0.764	-0.200
		17	0.786	hsa-miR-103	hsa-miR-223	0.840	0.025
5	0.957	14	0.871	hsa-miR-101	hsa-miR-191	0.822	-0.009
		16	0.810	hsa-miR-197	hsa-miR-378	-0.234	0.586
6	0.952	12	0.768	hsa-miR-101	hsa-miR-103	0.805	-0.060
		13	0.801	hsa-miR-125b	hsa-miR-24	-0.073	0.768
7	0.951	5	0.867	hsa-miR-192	hsa-miR-197	-0.281	0.631
		9	0.872	hsa-miR-191	hsa-miR-320a	0.691	-0.182
8	0.951	14	0.871	hsa-miR-101	hsa-miR-191	0.822	-0.009
		17	0.786	hsa-miR-103	hsa-miR-223	0.840	0.025
9	0.951	1	0.880	hsa-miR-191	hsa-miR-590-5p	0.764	-0.200
		15	0.745	hsa-miR-103	hsa-miR-222	0.622	-0.207
10	0.947	4	0.797	hsa-miR-103	hsa-miR-19b	0.776	-0.141
		14	0.871	hsa-miR-101	hsa-miR-191	0.822	-0.009

^*: Original rank and AUC of each pair of miRNAs in Table 3. Bold: top five miRNAs

ISSN: 2050-7771