Table 4 GELA grading system for post-treatment evaluation of gastric MALT lymphoma [35]
GELA category | Histological features | Clinical category |
|---|---|---|
Complete histological response (CR) | Total disappearance of lymphoid infiltrate with only scattered small lymphocytes and plasma cells. Regressive stromal changes with fibrosis and separation of glands can be observed. | Complete remission |
Probable minimal residual disease (pMRD) | Small lymphoid aggregates present, stromal regressive changes are usually present. | Complete remission |
Responding residual disease (rRD) | Overt residual lymphoma with a nodular or diffuse infiltrate of neoplastic B-cells but with clear evidence of regressive stromal changes characterized by fine fibrosis and an “empty lamina propria.” | Partial remission |
No change (NC) | Persistence of overt lymphoma identical to that observed at diagnosis with no morphological features to suggest response to treatment (such as stromal fibrosis). | Stable or progressive disease |