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Table 1 Wotherspoon scale of confidence of histological diagnosis of lymphoma [15]

From: Gastric mucosa-associated lymphoid tissue lymphoma and Helicobacter pylori infection: a review of current diagnosis and management

Grade

Description

Histological features

0

Normal

Scattered plasma cells in the lamina propria. No lymphoid follicles.

1

Chronic active gastritis

Small clusters of lymphocytes in the lamina propria. No lymphoid follicles. No LELs.

2

Chronic active gastritis with florid lymphoid follicle formation

Prominent lymphoid follicles with surrounding mantle zone and plasma cells.

3

Suspicious lymphoid infiltrate, probably reactive

Lymphoid follicles surrounded by CCL cells that infiltrate diffusely into the lamina propria and occasionally into the epithelium.

4

Suspicious lymphoid infiltrate, probably lymphoma

Lymphoid follicles surrounded by CCL cells that infiltrate diffusely into the lamina propria and into the epithelium in small groups.

5

Low-grade B-cell lymphoma of MALT

Presence of dense diffuse infiltrate of CCL cells in the lamina propria with prominent lymphoepithelial lesions.

  1. CCL cells centrocyte-like cells (or marginal zone cells), LEL lymphoepithelial lesion