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  1. Review

    Critical appraisal of the role of serum albumin in cardiovascular disease

    Concentration of serum albumin (SA), a multifunctional circulatory protein, is influenced by several factors, including its synthesis rate, catabolism rate, extravascular distribution, and exogenous loss. More...

    Shih-Chieh Chien, Chun-Yen Chen, Chao-Feng Lin and Hung-I Yeh

    Biomarker Research 2017 5:31

    Published on: 10 November 2017

  2. Research

    Evaluation of two high-throughput proteomic technologies for plasma biomarker discovery in immunotherapy-treated melanoma patients

    Selective kinase and immune checkpoint inhibitors, and their combinations, have significantly improved the survival of patients with advanced metastatic melanoma. Not all patients will respond to treatment how...

    Su Yin Lim, Jenny H. Lee, Sarah J. Welsh, Seong Beom Ahn, Edmond Breen, Alamgir Khan, Matteo S. Carlino, Alexander M. Menzies, Richard F. Kefford, Richard A. Scolyer, Georgina V. Long and Helen Rizos

    Biomarker Research 2017 5:32

    Published on: 10 November 2017

  3. Research

    Assessing biological and technological variability in protein levels measured in pre-diagnostic plasma samples of women with breast cancer

    Quantitative proteomics allows for the discovery and functional investigation of blood-based pre-diagnostic biomarkers for early cancer detection. However, a major limitation of proteomic investigations in bio...

    Christine Y. Yeh, Ravali Adusumilli, Majlinda Kullolli, Parag Mallick, Esther M. John and Sharon J. Pitteri

    Biomarker Research 2017 5:30

    Published on: 17 October 2017

  4. Research

    Development of a fully automated chemiluminescence immunoassay for urine monomeric laminin-γ2 as a promising diagnostic tool of non-muscle invasive bladder cancer

    Monomeric laminin-γ2 in urine is a potential biomarker for bladder cancer. However, the current detection system uses an antibody that cannot discriminate between monomeric laminin-γ2 and the heterotrimeric γ2...

    Masatoshi Nakagawa, Takashi Karashima, Masayuki Kamada, Eisaku Yoshida, Toru Yoshimura, Masanori Nojima, Keiji Inoue, Taro Shuin, Motoharu Seiki and Naohiko Koshikawa

    Biomarker Research 2017 5:29

    Published on: 13 October 2017

  5. Methodology

    Comparative study of two protocols for quantitative image-analysis of serotonin transporter clustering in lymphocytes, a putative biomarker of therapeutic efficacy in major depression

    The pattern of serotonin transporter clustering on the plasma membrane of lymphocytes extracted from human whole blood samples has been identified as a putative biomarker of therapeutic efficacy in major depre...

    Raquel Romay-Tallon, Tania Rivera-Baltanas, Josh Allen, Jose M. Olivares, Lisa E. Kalynchuk and Hector J. Caruncho

    Biomarker Research 2017 5:27

    Published on: 22 September 2017

  6. Research

    Re-evaluation of soluble APP-α and APP-β in cerebrospinal fluid as potential biomarkers for early diagnosis of dementia disorders

    Because soluble (or secreted) amyloid precursor protein-β (sAPPβ) and -α (sAPPα) possibly reflect pathological features of Alzheimer’s disease (AD), they are potential biomarker candidates for dementia disorde...

    Wataru Araki, Kotaro Hattori, Kazutomi Kanemaru, Yuma Yokoi, Yoshie Omachi, Harumasa Takano, Masuhiro Sakata, Sumiko Yoshida, Tadashi Tsukamoto, Miho Murata, Yuko Saito, Hiroshi Kunugi, Yu-ichi Goto, Utako Nagaoka, Masahiro Nagao, Takashi Komori…

    Biomarker Research 2017 5:28

    Published on: 22 September 2017

  7. Research

    Elevation of brain-enriched miRNAs in cerebrospinal fluid of patients with acute ischemic stroke

    The purpose of this study was to investigate the potential of cerebrospinal fluid miRNAs as diagnostic biomarkers of acute ischemic stroke using three different profiling techniques in order to identify and by...

    Sofie Sølvsten Sørensen, Ann-Britt Nygaard, Anting Liu Carlsen, Niels H. H. Heegaard, Mads Bak and Thomas Christensen

    Biomarker Research 2017 5:24

    Published on: 11 July 2017

  8. Review

    Engineering CAR-T cells

    Chimeric antigen receptor redirected T cells (CAR-T cells) have achieved inspiring outcomes in patients with B cell malignancies, and are now being investigated in other hematologic malignancies and solid tumo...

    Cheng Zhang, Jun Liu, Jiang F. Zhong and Xi Zhang

    Biomarker Research 2017 5:22

    Published on: 24 June 2017

  9. Research

    Higher serum concentrations of vimentin and DAKP1 are associated with aggressive breast tumour phenotypes in Ghanaian women

    Breast cancer, the most commonly diagnosed cancer among women and leading cause of cancer-related deaths worldwide, exhibits aggressive behavior in indigenous African women evidenced by high histologic grade t...

    Benjamin Arko-Boham, Justice Tanihu Lomotey, Emmanuel Nomo Tetteh, Emmanuel Ayitey Tagoe, Nii Ayite Aryee, Ewurama Ampadu Owusu, Isaac Okai, Richard Michael Blay and Joe-Nat Clegg-Lamptey

    Biomarker Research 2017 5:21

    Published on: 9 June 2017

  10. Research

    Circulating tumor cell clusters-associated gene plakoglobin is a significant prognostic predictor in patients with breast cancer

    Circulating tumor cells (CTCs) are linked to metastatic relapse and are regarded as a prognostic marker for human cancer. High expression of plakoglobin, a cell adhesion protein, within the primary tumor is po...

    Wataru Goto, Shinichiro Kashiwagi, Yuka Asano, Koji Takada, Katsuyuki Takahashi, Takaharu Hatano, Tsutomu Takashima, Shuhei Tomita, Hisashi Motomura, Masahiko Ohsawa, Kosei Hirakawa and Masaichi Ohira

    Biomarker Research 2017 5:19

    Published on: 12 May 2017

  11. Short report

    Clinical significance of intronic variants in BRAF inhibitor resistant melanomas with altered BRAF transcript splicing

    Alternate BRAF splicing is the most common mechanism of acquired resistance to BRAF inhibitor treatment in melanoma. Recently, alternate BRAF exon 4–8 splicing was shown to involve an intronic mutation, locate...

    Gulietta M. Pupo, Suzanah C. Boyd, Carina Fung, Matteo S. Carlino, Alexander M. Menzies, Bernadette Pedersen, Peter Johansson, Nicholas K. Hayward, Richard F. Kefford, Richard A. Scolyer, Georgina V. Long and Helen Rizos

    Biomarker Research 2017 5:17

    Published on: 11 May 2017

  12. Case report

    Autoimmune hemolytic anemia associated with babesiosis

    Babesiosis is endemic in selected areas in North America. Babesia infection is commonly associated with anemia, thrombocytopenia, hyponatremia and elevated liver enzymes. Autoimmune hemolytic anemia (AIHA) is ...

    Roshni Narurkar, Aleksandra Mamorska-Dyga, John C. Nelson and Delong Liu

    Biomarker Research 2017 5:14

    Published on: 8 April 2017

  13. Case series

    Length of hospitalization is associated with selected biomarkers (albumin and lymphocytes) and with co-morbidities: study on 4000 patients

    Low albumin levels and low lymphocyte counts are intra hospital conditions that exert a negative influence on prognosis, healing and length of hospitalization. The study aimed to analyze the correlation betwee...

    Antonio E. Pontiroli, Lara Loreggian, Marco P. L. Rovati, Elena De Patto, Laura Folini, Federico Raveglia, Matilde De Simone, Alessandro Baisi and Ugo Cioffi

    Biomarker Research 2017 5:13

    Published on: 21 March 2017

  14. Research

    Podocalyxin-like and RNA-binding motif protein 3 are prognostic biomarkers in urothelial bladder cancer: a validatory study

    Urothelial bladder cancer (UBC) is a disease that often is discovered when the tumour is non-muscle invasive, i.e. in Ta or T1 stage. Some patients will progress into muscle-invasive disease, a potentially dea...

    Karolina Boman, Gustav Andersson, Christoffer Wennersten, Björn Nodin, Göran Ahlgren and Karin Jirström

    Biomarker Research 2017 5:10

    Published on: 14 March 2017

  15. Research

    Application of penalized linear regression methods to the selection of environmental enteropathy biomarkers

    Environmental Enteropathy (EE) is a subclinical condition caused by constant fecal-oral contamination and resulting in blunting of intestinal villi and intestinal inflammation. Of primary interest in the clini...

    Miao Lu, Jianhui Zhou, Caitlin Naylor, Beth D. Kirkpatrick, Rashidul Haque, William A. Petri Jr and Jennie Z. Ma

    Biomarker Research 2017 5:9

    Published on: 9 March 2017

  16. Research

    Tissue MicroRNA profiles as diagnostic and prognostic biomarkers in patients with resectable pancreatic ductal adenocarcinoma and periampullary cancers

    The aim of this study was to validate previously described diagnostic and prognostic microRNA expression profiles in tissue samples from patients with pancreatic cancer and other periampullary cancers.

    Dan Calatayud, Christian Dehlendorff, Mogens K. Boisen, Jane Preuss Hasselby, Nicolai Aagaard Schultz, Jens Werner, Heike Immervoll, Anders Molven, Carsten Palnæs Hansen and Julia S. Johansen

    Biomarker Research 2017 5:8

    Published on: 21 February 2017

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