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  1. N6-methyladenosine (m6A) is a prevalent internal RNA modification in higher eukaryotic cells. As the pivotal m6A regulator, RNA methyltransferase-like 3 (METTL3) is responsible for methyl group transfer in the pr...

    Authors: Yiqing Cai, Rui Feng, Tiange Lu, Xiaomin Chen, Xiangxiang Zhou and Xin Wang

    Citation: Biomarker Research 2021 9:27

    Content type: Review

    Published on:

  2. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Jie Wu, Chunlei Zheng, Yizhe Wang, Zichang Yang, Ce Li, Wanxia Fang, Yue Jin, Kezuo Hou, Yang Cheng, Jianfei Qi, Xiujuan Qu, Yunpeng Liu, Xiaofang Che and Xuejun Hu

    Citation: Biomarker Research 2021 9:25

    Content type: Correction

    Published on:

    The original article was published in Biomarker Research 2021 9:9

  3. Dalpiciclib (SHR6390) is a novel inhibitor of cyclin-dependent kinase 4/6 which demonstrated promising anti-tumor potency in preclinical models. This first-in-human study was conducted to evaluate the tolerabi...

    Authors: Pin Zhang, Binghe Xu, Lin Gui, Wenna Wang, Meng Xiu, Xiao Zhang, Guilan Sun, Xiaoyu Zhu and Jianjun Zou

    Citation: Biomarker Research 2021 9:24

    Content type: Research

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  4. To evaluate the predictive value of AR-V7 expression detected by immunohistochemical (IHC) in the prognosis of prostate cancer patients receiving adjuvant hormonal therapy (AHT) following radical prostatectomy...

    Authors: Wei Ouyang, Yucong Zhang, Gongwei Long, Guoliang Sun, Man Liu, Fan Li, Chunguang Yang, Xing Zeng, Jun Yang, Xiao Yu, Zhihua Wang, Zheng Liu, Wei Guan, Zhiquan Hu, Shaogang Wang, Xiaming Liu…

    Citation: Biomarker Research 2021 9:23

    Content type: Research

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  5. The phase I trial of the humanized anti-CD26 monoclonal antibody YS110 for CD26-expressing tumors was conducted recently. The present study identifies a potential prognostic biomarker for CD26-targeted therapy...

    Authors: Yutaro Kaneko, Ryo Hatano, Naoto Hirota, Nicolas Isambert, Véronique Trillet-Lenoir, Benoit You, Jérôme Alexandre, Gérard Zalcman, Fanny Valleix, Thomas Podoll, Yoshimi Umezawa, Seiichi Takao, Satoshi Iwata, Osamu Hosono, Tetsuo Taguchi, Taketo Yamada…

    Citation: Biomarker Research 2021 9:21

    Content type: Research

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  6. We evaluated organ-specific response rates (OSRRs) to first-line lenvatinib plus anti-PD-1 antibodies in patients with advanced hepatocellular carcinoma (HCC).

    Authors: Cheng Huang, Xiao-Dong Zhu, Ying-Hao Shen, Dong Wu, Yuan Ji, Ning-Ling Ge, Ling-Li Chen, Chang-Jun Tan, Jian Zhou, Jia Fan and Hui-Chuan Sun

    Citation: Biomarker Research 2021 9:19

    Content type: Research

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  7. miRNA-21 is among the most abundant and highly conserved microRNAs (miRNAs) recognized. It is expressed in essentially all cells where it performs vital regulatory roles in health and disease. It is also frequ...

    Authors: Ana E. Jenike and Marc K. Halushka

    Citation: Biomarker Research 2021 9:18

    Content type: Review

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  8. T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive subtype of leukemia with poor prognosis, and biomarkers and novel therapeutic targets are urgently needed for this disease. Our previous studies hav...

    Authors: Kehan Li, Cunte Chen, Rili Gao, Xibao Yu, Youxue Huang, Zheng Chen, Zhuandi Liu, Shaohua Chen, Gengxin Luo, Xin Huang, Grzegorz K. Przybylski, Yangqiu Li and Chengwu Zeng

    Citation: Biomarker Research 2021 9:17

    Content type: Letter to the Editor

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  9. Chromodomain helicase/ATPase DNA binding protein 1-like gene (CHD1L) is a multifunctional protein participated in diverse cellular processes, including chromosome remodeling, cell differentiation and developme...

    Authors: Xifeng Xiong, Xudong Lai, Aiguo Li, Zhihe Liu and Ningfang Ma

    Citation: Biomarker Research 2021 9:16

    Content type: Review

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  10. Knowledge of immune cell phenotypes, function, and developmental trajectory in acute myeloid leukemia (AML) microenvironment is essential for understanding mechanisms of evading immune surveillance and immunot...

    Authors: Rongqun Guo, Mengdie Lü, Fujiao Cao, Guanghua Wu, Fengcai Gao, Haili Pang, Yadan Li, Yinyin Zhang, Haizhou Xing, Chunyan Liang, Tianxin Lyu, Chunyan Du, Yingmei Li, Rong Guo, Xinsheng Xie, Wei Li…

    Citation: Biomarker Research 2021 9:15

    Content type: Research

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  11. A subset of men with metastatic prostate cancer (mPC) responds to immune checkpoint inhibitors, and there is an unmet need to predict those most likely to benefit. We characterized circulating tumor cells (CTC...

    Authors: Tian Zhang, Anika Agarwal, R. Garland Almquist, Daniella Runyambo, Sally Park, Elizabeth Bronson, Rengasamy Boominathan, Chandra Rao, Monika Anand, Taofik Oyekunle, Patrick Healy, Megan A. McNamara, Kathryn Ware, Jason A. Somarelli, Daniel J. George and Andrew J. Armstrong

    Citation: Biomarker Research 2021 9:14

    Content type: Rapid communication

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  12. We used the eXtreme Gradient Boosting algorithm, an optimized gradient boosting machine learning library, and established a model to predict events in Philadelphia chromosome-positive acute lymphoblastic leuke...

    Authors: Satoshi Nishiwaki, Isamu Sugiura, Daisuke Koyama, Yukiyasu Ozawa, Masahide Osaki, Yuichi Ishikawa and Hitoshi Kiyoi

    Citation: Biomarker Research 2021 9:13

    Content type: Letter to the Editor

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  13. Early diagnosis of esophageal squamous cell carcinoma (ESCC) remains a challenge due to the lack of specific blood biomarkers. We aimed to develop a serum multi-protein signature for the early detection of ESCC.

    Authors: Xiaorong Yang, Chen Suo, Tongchao Zhang, Xiaolin Yin, Jinyu Man, Ziyu Yuan, Jingru Yu, Li Jin, Xingdong Chen, Ming Lu and Weimin Ye

    Citation: Biomarker Research 2021 9:12

    Content type: Research

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  14. Malignant mesothelioma (MM) is a treatment-resistant tumor originating in the mesothelial lining of the pleura or the abdominal cavity with very limited treatment options. More effective therapeutic approaches...

    Authors: Laura Castelletti, Dannel Yeo, Nico van Zandwijk and John E. J. Rasko

    Citation: Biomarker Research 2021 9:11

    Content type: Review

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  15. Experimental evidence points to the role of Zinc fingers and homeoboxes protein 1 and 2 (ZHX1 and ZHX2) in the development and progression of several types of cancer, including hematological malignancies. Here...

    Authors: Natália Ioseph Gladistone Maciel, Luma Dayane Carvalho Filiú-Braga, Francisco Assis Rocha Neves, Eduardo Magalhaes Rego, Antonio Roberto Lucena-Araujo and Felipe Saldanha-Araujo

    Citation: Biomarker Research 2021 9:10

    Content type: Letter to the Editor

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  16. Epidermal growth factor receptor-tyrosinase kinase inhibitor (EGFR-TKI) resistance is the major obstacle in the treatment of lung adenocarcinoma (LUAD) patients harboring EGFR-sensitive mutations. However, the...

    Authors: Jie Wu, Chunlei Zheng, Yizhe Wang, Zichang Yang, Ce Li, Wanxia Fang, Yue Jin, Kezuo Hou, Yang Cheng, Jianfei Qi, Xiujuan Qu, Yunpeng Liu, Xiaofang Che and Xuejun Hu

    Citation: Biomarker Research 2021 9:9

    Content type: Research

    Published on:

    The Correction to this article has been published in Biomarker Research 2021 9:25

  17. Chronic myeloid leukemia (CML) and chronic neutrophilic leukemia (CNL) are two myeloproliferative neoplasms with mutually exclusive diagnostic criteria. A hallmark of CML is the Philadelphia chromosome (Ph), w...

    Authors: Sarah A. Carratt, Diana Brewer, Julia E. Maxson, Brian J. Druker and Theodore P. Braun

    Citation: Biomarker Research 2021 9:8

    Content type: Case report

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  18. Tumor protein 63 (p63) is a transcription factor of the p53 gene family involved in differentiation of several tissues including squamous epithelium. p63 immunohistochemistry is broadly used for tumor classifi...

    Authors: Stefan Steurer, Claudia Riemann, Franziska Büscheck, Andreas M. Luebke, Martina Kluth, Claudia Hube-Magg, Andrea Hinsch, Doris Höflmayer, Sören Weidemann, Christoph Fraune, Katharina Möller, Anne Menz, Margit Fisch, Michael Rink, Christian Bernreuther, Patrick Lebok…

    Citation: Biomarker Research 2021 9:7

    Content type: Research

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  19. Infection and graft-versus-host disease (GvHD) are the major causes for mortality and morbidity of allogeneic hematopoietic stem cell transplantation (allo-HSCT). Plasma-derived extracellular vesicles (EVs) co...

    Authors: Hooi Ching Lim, Shamit Soneji, Róbert Pálmason, Stig Lenhoff, Thomas Laurell and Stefan Scheding

    Citation: Biomarker Research 2021 9:6

    Content type: Research

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  20. Biomarkers that can objectively guide the diagnosis of sports-related concussion, and consequent return-to-play decisions, are urgently needed. In this study, we aimed to determine the temporal profile and dia...

    Authors: Stuart J. McDonald, William T. O’Brien, Georgia F. Symons, Zhibin Chen, Jesse Bain, Brendan P. Major, Daniel Costello, Glenn Yamakawa, Mujun Sun, Rhys D. Brady, Biswadev Mitra, Richelle Mychasiuk, Terence J. O’Brien and Sandy R. Shultz

    Citation: Biomarker Research 2021 9:4

    Content type: Research

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  21. Alzheimer’s disease (AD) is the most common cause of dementia and most of AD patients suffer from vascular abnormalities and neuroinflammation. There is an urgent need to develop novel blood biomarkers capable...

    Authors: Jung Eun Park, Do Sung Lim, Yeong Hee Cho, Kyu Yeong Choi, Jang Jae Lee, Byeong C. Kim, Kun Ho Lee and Jung Sup Lee

    Citation: Biomarker Research 2021 9:5

    Content type: Research

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  22. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Antonio E. Pontiroli, Lara Loreggian, Marco P. L. Rovati, Elena De Patto, Laura Folini, Federico Raveglia, Matilde De Simone, Alessandro Baisi and Ugo Cioffi

    Citation: Biomarker Research 2021 9:3

    Content type: Correction

    Published on:

    The original article was published in Biomarker Research 2017 5:13

  23. Cancer-associated adipocytes (CAAs), as a main component of the tumor-adipose microenvironment (TAME), have various functions, including remodeling the extracellular matrix and interacting with tumor cells or ...

    Authors: Qi Wu, Bei Li, Juanjuan Li, Si Sun, Jingping Yuan and Shengrong Sun

    Citation: Biomarker Research 2021 9:2

    Content type: Review

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  24. Macrophages are critical mediators of tissue homeostasis, with the function of tissue development and repair, but also in defense against pathogens. Tumor-associated macrophages (TAMs) are considered as the ma...

    Authors: Yang Liu, Ruyi Xu, Huiyao Gu, Enfan Zhang, Jianwei Qu, Wen Cao, Xi Huang, Haimeng Yan, Jingsong He and Zhen Cai

    Citation: Biomarker Research 2021 9:1

    Content type: Review

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  25. Myeloproliferative neoplasms are characterized by mutations in JAK2, MPL and CALR genes. Commonly in diagnostics and previous studies mainly sequencing and common PCR techniques under conventional detection li...

    Authors: Luise Grunwald, Christina Grosse-Thie, Sina Sender, Gudrun Knuebel, Saskia Krohn, Catrin Roolf, Christian Junghanss, Larissa Henze and Hugo Murua Escobar

    Citation: Biomarker Research 2020 8:73

    Content type: Letter to the Editor

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  26. Ibrutinib, an irreversible Bruton Tyrosine Kinase (BTK) inhibitor, has revolutionized Chronic Lymphocytic Leukemia (CLL) treatment, but resistances to ibrutinib have emerged, whether related or not to BTK muta...

    Authors: Sarah Cadot, Carine Valle, Marie Tosolini, Frederic Pont, Laetitia Largeaud, Camille Laurent, Jean Jacques Fournie, Loic Ysebaert and Anne Quillet-Mary

    Citation: Biomarker Research 2020 8:72

    Content type: Research

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  27. Hepatocellular carcinoma (HCC) is a type of liver cancer with poor prognosis. There have been demonstrated to exist many possible mechanisms in HCC tumorigenesis, and recent investigations have provided some p...

    Authors: Mengzhen Han, Zhibin Liao, Furong Liu, Xiaoping Chen and Bixiang Zhang

    Citation: Biomarker Research 2020 8:70

    Content type: Review

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  28. In recent years, there have been advancements in traditional patterns of tumor therapy with the adoption of immunotherapy. Its application with or without other combined regimens has attracted attention from c...

    Authors: Xuhong Liu and Yong Yi

    Citation: Biomarker Research 2020 8:69

    Content type: Review

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  29. Esophageal cancer (ECa) is the 7th most incident cancer and the 6th leading cause of cancer-related death. Most patients are diagnosed with locally advanced or metastatic disease, enduring poor survival. Bioma...

    Authors: Sofia Salta, Catarina Macedo-Silva, Vera Miranda-Gonçalves, Nair Lopes, Davide Gigliano, Rita Guimarães, Mónica Farinha, Olga Sousa, Rui Henrique and Carmen Jerónimo

    Citation: Biomarker Research 2020 8:68

    Content type: Research

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  30. Although anti-CD19 chimeric antigen receptor (CAR) T-cell therapy shows good efficacy in patients with relapsed/refractory B-cell acute lymphoblastic leukemia (r/r B-ALL), it fails to improve long-term leukemi...

    Authors: Huiwen Jiang, Yu Hu and Heng Mei

    Citation: Biomarker Research 2020 8:66

    Content type: Review

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  31. Recently, novel drugs like venetoclax plus 5-azacytidine (VA) were reported to have promising efficacy in refractory acute myeloid leukemia (AML). However, there are still some cases presented with novel drugs...

    Authors: JingHan Wang, Xingnong Ye, Cuihua Fan, Jie Zhou, Shuna Luo, Jingxia Jin, Dan Chen, Yan Zheng, Cai Wu, Xiaoqiong Zhu, Jie Jin and Jian Huang

    Citation: Biomarker Research 2020 8:65

    Content type: Letter to the Editor

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  32. Cancer-associated fibroblasts (CAFs) are the key component of tumor stromal. High heterogeneity of CAFs reflects in their origin, phenotype and function. Biological function which can be suggested by biomarker...

    Authors: Chencheng Han, Tongyan Liu and Rong Yin

    Citation: Biomarker Research 2020 8:64

    Content type: Review

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  33. Excessive generation of reactive oxygen species (ROS) in the presence of a defective antioxidant system can induce cellular damage and disrupt normal physiological functions. Several studies have revealed the ...

    Authors: Natasha Mupeta Kaweme, Shu Zhou, Geoffrey Joseph Changwe and Fuling Zhou

    Citation: Biomarker Research 2020 8:63

    Content type: Review

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  34. SETD2 is the only methyltransferase for H3K36me3, and our previous study has firstly demonstrated that it functioned as one tumor suppressor in hematopoiesis. Consistent with it, SETD2 mutation, which led to its ...

    Authors: Jiewen Sun, Wenjuan Yu and Xiang Zhang

    Citation: Biomarker Research 2020 8:62

    Content type: Letter to the Editor

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  35. Non-coding RNAs are the main component of the extensive transcription results of the mammalian genome. They are not transcribed into proteins but play critical roles in regulating multiple biological processes...

    Authors: Xinyu Yang, Xiang Hu, Jinting Liu, Ruiqing Wang, Chen Zhang, Fengjiao Han, Yuhong Chen and Daoxin Ma

    Citation: Biomarker Research 2020 8:61

    Content type: Review

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  36. Malignant tumor is a largely harmful disease worldwide. The cure rate of malignant tumors increases with the continuous discovery of anti-tumor drugs and the optimisation of chemotherapy options. However, drug...

    Authors: Zhe Dai, Xu-yu Gu, Shou-yan Xiang, Dan-dan Gong, Chang-feng Man and Yu Fan

    Citation: Biomarker Research 2020 8:60

    Content type: Review

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  37. Chronic consumption of high sugar and high fat diet associated with liver inflammation and cognitive decline. This paper tests a hypothesis that the development and resolution of diet-induced nonalcoholic fatt...

    Authors: Prasant Kumar Jena, Lili Sheng, Michelle Nguyen, Jacopo Di Lucente, Ying Hu, Yongchun Li, Izumi Maezawa, Lee-Way Jin and Yu-Jui Yvonne Wan

    Citation: Biomarker Research 2020 8:59

    Content type: Research

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  38. Ferroptosis is a recently discovered distinct type of regulated cell death caused by the accumulation of lipid-based ROS. Metabolism and expression of specific genes affect the occurrence of ferroptosis, makin...

    Authors: Zhaoqing Li, Lini Chen, Cong Chen, Yulu Zhou, Dengdi Hu, Jingjing Yang, Yongxia Chen, Wenying Zhuo, Misha Mao, Xun Zhang, Ling Xu, Linbo Wang and Jichun Zhou

    Citation: Biomarker Research 2020 8:58

    Content type: Review

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  39. On-target off-tumor toxicity impedes the clinical application of chimeric antigen receptor-modified T cells (CAR-T cells) in the treatment of solid tumors. Previous reports proved that the combinatorial antige...

    Authors: Qibin Liao, Yunyu Mao, Huan He, Xiangqing Ding, Xiaoyan Zhang and Jianqing Xu

    Citation: Biomarker Research 2020 8:57

    Content type: Research

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  40. Chimeric antigen receptor-modified T cells (CAR-T cells) have shown good effects in the treatment of hematologic cancers; however, they may cause on-target off-tumor toxicity because of minimal expression of t...

    Authors: Qibin Liao, Huan He, Yunyu Mao, Xiangqing Ding, Xiaoyan Zhang and Jianqing Xu

    Citation: Biomarker Research 2020 8:56

    Content type: Letter to the Editor

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  41. To date, the association of serum macrophage migration inhibitory factor (MIF) and serum adipokines with lupus nephritis is controversial.

    Authors: Jorge Ivan Gamez-Nava, Valeria Diaz-Rizo, Edsaul Emilio Perez-Guerrero, Jose Francisco Muñoz-Valle, Ana Miriam Saldaña-Cruz, Nicte Selene Fajardo-Robledo, Heriberto Jacobo-Cuevas, Cesar Arturo Nava-Valdivia, Miriam Fabiola Alcaraz-Lopez, Xochitl Trujillo, Miguel Huerta, Ernesto German Cardona-Muñoz and Laura Gonzalez-Lopez

    Citation: Biomarker Research 2020 8:55

    Content type: Research

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  42. T-cell prolymphocytic leukemia (T-PLL) is a poor prognostic disease with very limited options of efficient therapies. Most patients are refractory to chemotherapies and despite high response rates after alemtu...

    Authors: Carlos Cuesta-Mateos, Patricia Fuentes, Alexandra Schrader, Raquel Juárez-Sánchez, Javier Loscertales, Tamara Mateu-Albero, Lorena Vega-Piris, Marina Espartero-Santos, Ana Marcos-Jimenez, Blanca Andrea Sánchez-López, Yaiza Pérez-García, Dennis Jungherz, Sebastian Oberbeck, Linus Wahnschaffe, Anna Kreutzman, Emma I. Andersson…

    Citation: Biomarker Research 2020 8:54

    Content type: Rapid communication

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  43. New biomarkers are urgently needed to improve personalized treatment approaches for head and neck squamous cell carcinoma (HNSCC). Global DNA hypomethylation has wide-ranging functions in multistep carcinogene...

    Authors: Kiyoshi Misawa, Satoshi Yamada, Masato Mima, Takuya Nakagawa, Tomoya Kurokawa, Atsushi Imai, Daiki Mochizuki, Daichi Shinmura, Taiki Yamada, Junya Kita, Ryuji Ishikawa, Yuki Yamaguchi, Yuki Misawa, Takeharu Kanazawa, Hideya Kawasaki and Hiroyuki Mineta

    Citation: Biomarker Research 2020 8:53

    Content type: Research

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  44. Screening across a multitude of normal and malignant tissues revealed an enhanced expression of lymphocyte antigen 6 superfamily member D (LY6D) in squamous epithelium and urothelium, as well as in malignancie...

    Authors: Nina Andersson, Johan Ohlsson, Sara Wahlin, Björn Nodin, Karolina Boman, Sebastian Lundgren and Karin Jirström

    Citation: Biomarker Research 2020 8:51

    Content type: Research

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