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  1. Immunotherapy is currently under investigation in B3 Thymoma (TB3) and Thymic Carcinoma (TC). PD-L1 expression has been evaluated on a limited number of patients with selected antibodies. We aimed to analyze c...

    Authors: Isabelle Rouquette, Estelle Taranchon-Clermont, Julia Gilhodes, Maria-Virginia Bluthgen, Romain Perallon, Lara Chalabreysse, Anne De Muret, Veronique Hofman, Alexander Marx, Marie Parrens, Veronique Secq, Vincent Thomas de Montpreville, Françoise Galateau-Salle, Pierre Brousset, Julie Milia, Nicolas Girard…

    Citation: Biomarker Research 2019 7:28

    Content type: Research

    Published on:

  2. Tamoxifen treatment has previously been reported to confer life-prolonging effects in patients with advanced pancreatic cancer, and most evidently so in women. None of these trials did however include biomarke...

    Authors: Gustav Andersson, Sebastian Lundgren, Margareta Heby, Björn Nodin, Jacob Elebro and Karin Jirström

    Citation: Biomarker Research 2019 7:26

    Content type: Research

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  3. Tumor-associated antigens (TAA) or cancer biomarkers are major targets for cancer therapies. Antibody- based agents targeting the cancer biomarkers include monoclonal antibodies (MoAbs), radiolabeled MoAbs, bi...

    Authors: Delong Liu

    Citation: Biomarker Research 2019 7:25

    Content type: Editorial

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  4. Phenotypic and functional heterogeneity is one of the hallmarks of human cancers. Tumor genotype variations among tumors within different patients are known as interpatient heterogeneity, and variability among...

    Authors: Mingzhou Guo, Yaojun Peng, Aiai Gao, Chen Du and James G. Herman

    Citation: Biomarker Research 2019 7:23

    Content type: Review

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  5. The original article [1] contains an error in the legend of Fig. 1 whereby it is incorrectly stated that MEC stands for ‘mitoprostate cancer using magnetic resonance imagingxantrone, etoposide, cyclophosphamid...

    Authors: Juanjuan Zhao, Yongping Song and Delong Liu

    Citation: Biomarker Research 2019 7:21

    Content type: Correction

    Published on:

    The original article was published in Biomarker Research 2019 7:19

  6. This study evaluated breast tissue stiffness measured by ultrasound elastography and the percent breast density measured by magnetic resonance imaging to understand their relationship.

    Authors: Jeon-Hor Chen, Siwa Chan, Yang Zhang, Shunshan Li, Ruey-Feng Chang and Min-Ying Su

    Citation: Biomarker Research 2019 7:20

    Content type: Research

    Published on:

  7. FMS-like tyrosine kinase 3- internal tandem duplication (FLT3-ITD) remains as one of the most frequently mutated genes in acute myeloid leukemia (AML), especially in those with normal cytogenetics. The FLT3-IT...

    Authors: Juanjuan Zhao, Yongping Song and Delong Liu

    Citation: Biomarker Research 2019 7:19

    Content type: Review

    Published on:

    The Correction to this article has been published in Biomarker Research 2019 7:21

  8. CAR-T cell therapy targeting CD19 has achieved remarkable success in the treatment of B cell malignancies, while various solid malignancies are still refractory for lack of suitable target. In recent years, a ...

    Authors: Jiang Lv and Peng Li

    Citation: Biomarker Research 2019 7:18

    Content type: Review

    Published on:

  9. The peroxiredoxins (PRDXs) gene family has been demonstrated to participate in carcinogenesis and development of numerous cancers and the prognostic values in several cancers have been evaluated already. Purpo...

    Authors: Jie Mei, Leiyu Hao, Xiaorui Liu, Guangshun Sun, Rui Xu, Huiyu Wang and Chaoying Liu

    Citation: Biomarker Research 2019 7:16

    Content type: Research

    Published on:

  10. The discovery of JAK2V617F and the demonstration that BCR-ABL-negative myeloproliferative neoplasms (MPNs) are driven by abnormal JAK2 activation have led to advances in diagnostic algorithms, prognosis and ultim...

    Authors: Bing Li, Raajit K. Rampal and Zhijian Xiao

    Citation: Biomarker Research 2019 7:15

    Content type: Review

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  11. The epidermal growth factor receptor (EGFR) monoclonal IgG1 antibody cetuximab is approved for first-line treatment of recurrent and metastatic (R/M) HNSCC as a part of the standard of care EXTREME regimen (plati...

    Authors: Madelyn Espinosa-Cotton, Elana J. Fertig, Laura P. Stabile, Autumn Gaither-Davis, Julie E. Bauman, Sandra Schmitz, Katherine N. Gibson-Corley, Yinwen Cheng, Isaac J. Jensen, Vladimir P. Badovinac, Douglas Laux and Andrean L. Simons

    Citation: Biomarker Research 2019 7:14

    Content type: Research

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  12. The MPL protein is a major regulator of megakaryopoiesis and platelet formation as well as stem cell regulation. Aberrant MPL and downstream Jak/STAT signaling results in the development of the Myeloproliferat...

    Authors: Boguslaw A. Kwiatkowski, Nicolas R. Burwick and Robert E. Richard

    Citation: Biomarker Research 2019 7:13

    Content type: Research

    Published on:

  13. We previously identified a TCR Vβ21 T cell clone which was specific to CML patients, and demonstrated that TCR Vα13/β21 gene-modified CD3+ T cells had specific cytotoxicity for HLA-A11+ K562 cells. However, it re...

    Authors: Yikai Zhang, Ling Xu, Shaohua Chen, Xianfeng Zha, Wei Wei and Yangqiu Li

    Citation: Biomarker Research 2019 7:12

    Content type: Short report

    Published on:

  14. Changes in DNA methylation over the course of life may provide an indicator of risk for cancer. We explored longitudinal changes in CpG methylation from blood leukocytes, and likelihood of future cancer diagno...

    Authors: Alexandra H. Bartlett, Jane W. Liang, Jose Vladimir Sandoval-Sierra, Jay H. Fowke, Eleanor M. Simonsick, Karen C. Johnson and Khyobeni Mozhui

    Citation: Biomarker Research 2019 7:10

    Content type: Research

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  15. Early neurological deterioration (END) is common after stroke. Prediction could identify patients requiring additional monitoring and intervention. Purines, breakdown products of adenosine triphosphate which a...

    Authors: Alexander J. Martin, Nicholas Dale, Christopher H. E. Imray, Christine Roffe, Craig J. Smith, Faming Tian and Christopher I. Price

    Citation: Biomarker Research 2019 7:7

    Content type: Research

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  16. Mesenchymal stromal cells (MSC) are a heterogeneous cell population with self-renewal and the ability to differentiate into different lineages. The novel regulatory role of MSC in both adaptive and innate immu...

    Authors: Peilong Lai, Jianyu Weng, Liyan Guo, Xiaomei Chen and Xin Du

    Citation: Biomarker Research 2019 7:6

    Content type: Review

    Published on:

  17. Barrett’s esophagus (BE) and esophageal adenocarcinoma (EAC) incidence has been increasing in the United States for greater than 30 years. For the majority of EAC patients, treatment is limited and prognosis p...

    Authors: Emily M. Christman, Parthasarathy Chandrakesan, Nathaniel Weygant, John T. Maple, William M. Tierney, Kenneth J. Vega and Courtney W. Houchen

    Citation: Biomarker Research 2019 7:5

    Content type: Short report

    Published on:

  18. In current clinical practice, Serum Creatinine (SCr) is a commonly used marker for the diagnosis of acute kidney injury (AKI). Unfortunately, due to a delayed increase in SCr, it is unable to accurately estima...

    Authors: Shabnum Khawaja, Lena Jafri, Imran Siddiqui, Madiha Hashmi and Farooq Ghani

    Citation: Biomarker Research 2019 7:4

    Content type: Research

    Published on:

  19. Chronic inflammatory demyelinating polyneuropathy (CIDP) is characterised by significant clinical heterogeneity and as such reliable biomarkers are required to measure disease activity and assess treatment res...

    Authors: Anthony Khoo, Joseph Frasca and David Schultz

    Citation: Biomarker Research 2019 7:3

    Content type: Review

    Published on:

  20. Factors regulating transcription of pluripotency genes in congenital nevo-melanocytes are not known. Nevo-melanocytes belong somewhere in-between the ends of a spectrum where the normal epidermal melanocyte re...

    Authors: Dipanjan Basu, Cláudia M. Salgado, Janki R. Patel, Joie Zabec, Ryan M. Hoehl, Bruce Bauer and Miguel Reyes-Múgica

    Citation: Biomarker Research 2019 7:2

    Content type: Letter to the Editor

    Published on:

  21. There is a great unmet clinical need to identify patients with thin primary cutaneous melanomas (T1, Breslow thickness ≤ 1 mm) who have a high risk for tumour recurrence and death from melanoma. Kin of IRRE-li...

    Authors: Sebastian Lundgren, Helena Fagerström-Vahman, Cheng Zhang, Liv Ben-Dror, Adil Mardinoglu, Mathias Uhlen, Björn Nodin and Karin Jirström

    Citation: Biomarker Research 2019 7:1

    Content type: Letter to the Editor

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  22. Altered mitochondrial function and large-scale changes to DNA methylation patterns in the nuclear genome are both hallmarks of colorectal cancer (CRC). Mitochondria have multiple copies of a 16 kb circular gen...

    Authors: M. J. Morris, L. B. Hesson, R. C. Poulos, R. L. Ward, J. W. H. Wong and N. A. Youngson

    Citation: Biomarker Research 2018 6:37

    Content type: Research

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  23. In patients with myelodysplastic syndrome (MDS), bone marrow cells have an increased predisposition to apoptosis, yet MDS cells outcompete normal bone marrow (BM)-- suggesting that factors regulating growth po...

    Authors: Christine V. Ichim, Dzana D. Dervovic, Lap Shu Alan Chan, Claire J. Robertson, Alden Chesney, Marciano D. Reis and Richard A. Wells

    Citation: Biomarker Research 2018 6:36

    Content type: Research

    Published on:

  24. OPCML hypermethylation is considered a promising cancer biomarker. We examined methylation levels in the first exon of OPCML in two patient cohorts within the esophageal adenocarcinoma and gastric adenocarcinoma ...

    Authors: Natalia Castaño-Rodríguez, Georgia L. Popple, Gloria Liliana Porras-Hurtado, José Luis Cardona-Deazza, Juan José Montoya-Martinez, Antonio Javier Cadavid-Velez, Héctor William Toro-Hidalgo, Alba Ruth Cobo-Alvarado, Ofelia del Socorro Hincapié-Rincón, Stephen M. Riordan and Nadeem O. Kaakoush

    Citation: Biomarker Research 2018 6:35

    Content type: Short report

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  25. Enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase that is of great interest in human cancer. It has been shown to have a dual nature, as it can act as a gene repressor or activator. Studies hav...

    Authors: Rosemarie Tremblay-LeMay, Nasrin Rastgoo, Maryam Pourabdollah and Hong Chang

    Citation: Biomarker Research 2018 6:34

    Content type: Review

    Published on:

  26. A feature of myeloproliferative neoplasia is transforming to more aggressive and malignant myeloid neoplasia, including acute myeloid leukemia. Different pathogenesis mechanisms participate in transformation, ...

    Authors: Marte Karen Brattås, Kyrre Lilleeng, Randi Hovland, Ingvild Jenssen Lægreid, Marta Vorland, Friedemann Leh, Øystein Bruserud, Bjørn Tore Gjertsen and Håkon Reikvam

    Citation: Biomarker Research 2018 6:33

    Content type: Case report

    Published on:

  27. We aim to characterize the heterogeneous circulating tumour cells (CTCs) in peripheral blood, independently of physical or immunological purification, by using patient-derived xenografts (PDXs) models. CTC stu...

    Authors: Chiara Agnoletto, Linda Minotti, Laura Brulle-Soumare, Lorenzo Pasquali, Marco Galasso, Fabio Corrà, Federica Baldassari, Jean-Gabriel Judde, Stefano Cairo and Stefano Volinia

    Citation: Biomarker Research 2018 6:31

    Content type: Research

    Published on:

  28. In most women with ovarian cancer, the diagnosis occurs after dissemination of tumor cells beyond ovaries. Several molecular perturbations occur ahead of tumor initiation including loss of lamin A/C. Our hypot...

    Authors: Callinice D Capo-chichi, Kathy Q Cai and Xiang-Xi Xu

    Citation: Biomarker Research 2018 6:30

    Content type: Research

    Published on:

  29. Recurrent gene mutations have been described with varying frequencies in myelodysplasia (MDS) /myeloproliferative neoplasm (MPN) overlap syndromes (MMOS). Recent work has placed significant focus on understand...

    Authors: Amandeep Aujla, Katherine Linder, Chaitanya Iragavarapu, Michael Karass and Delong Liu

    Citation: Biomarker Research 2018 6:29

    Content type: Review

    Published on:

  30. Metabolic syndrome is a cluster of abnormalities that increases the risk for type 2 diabetes and atherosclerosis. Plasma and serum water T2 from benchtop nuclear magnetic resonance relaxometry are early, global a...

    Authors: Vipulkumar Patel, Alok K. Dwivedi, Sneha Deodhar, Ina Mishra and David P. Cistola

    Citation: Biomarker Research 2018 6:28

    Content type: Research

    Published on:

  31. For children and young adults with T-lineage acute lymphoblastic leukemia (T-ALL), event free survival following relapse is < 10%. We recently showed that rearrangements of the mixed lineage leukemia gene (KMT2A-...

    Authors: Huining Kang, Nitesh D. Sharma, Christian K. Nickl, Meenakshi Devidas, Mignon L. Loh, Stephen P. Hunger, Kimberly P. Dunsmore, Stuart S. Winter and Ksenia Matlawska-Wasowska

    Citation: Biomarker Research 2018 6:27

    Content type: Rapid communication

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  32. Diagnosing pancreatic ductal adenocarcinoma (PDAC) in the setting of metastasis with an unknown primary remains very challenging due to the lack of specific biomarkers. HNF-1B has been characterized as an impo...

    Authors: Michelle X. Yang, Ryan F. Coates, Abiy Ambaye, Juli-Anne Gardner, Richard Zubarick, Yuan Gao, Joan Skelly, James G. Liu and Mari Mino-Kenudson

    Citation: Biomarker Research 2018 6:25

    Content type: Research

    Published on:

  33. The prognosis of adult T-cell leukemia-lymphoma (ATL) remains very poor, and there is an urgent clinical need to investigate novel therapies for ATL. The expression of phosphatidylinositol 3-kinase-δ (PI3k-δ) ...

    Authors: Hiroo Katsuya, Lucy B. M. Cook, Aileen G. Rowan, Yorifumi Satou, Graham P. Taylor and Charles R. M. Bangham

    Citation: Biomarker Research 2018 6:24

    Content type: Letter to the Editor

    Published on:

  34. Carcinogenesis is a multistep process which involves interplay between the tumour cells and the matrix proteins. This occurs by adherence between the tumour cells and proteins in the extracellular matrix. VHL ...

    Authors: Sandeep Kondisetty, Krishnakumar N. Menon and Ginil Kumar Pooleri

    Citation: Biomarker Research 2018 6:23

    Content type: Research

    Published on:

  35. For glioblastoma (GBM) treatments to be effective in vivo, understanding the effects of the tumor microenvironment is imperative. In traditional cell culture conditions, glucose concentrations do not model phy...

    Authors: Kiera Walker, Nathaniel H. Boyd, Joshua C. Anderson, Christopher D. Willey and Anita B. Hjelmeland

    Citation: Biomarker Research 2018 6:22

    Content type: Research

    Published on:

  36. Chemerin is a recently discovered adipokine shown to be involved in both inflammatory and metabolic processes. Here, we demonstrate that chemerin serum levels are elevated in patients with multiple myeloma and...

    Authors: Marita Westhrin, Siv Helen Moen, Ida Bruun Kristensen, Glenn Buene, Anne Kærsgaard Mylin, Ingemar Turesson, Niels Abildgaard, Anders Waage and Therese Standal

    Citation: Biomarker Research 2018 6:21

    Content type: Letter to the Editor

    Published on:

  37. Metronomic therapy has been gaining importance in the neoadjuvant setting of breast cancer treatment. Its clinical benefits may involve antiangiogenic machinery. Cancer cells induce angiogenesis to support tum...

    Authors: Roberto J. Arai, Vanessa Petry, Paulo M. Hoff and Max S. Mano

    Citation: Biomarker Research 2018 6:20

    Content type: Short report

    Published on:

  38. Colorectal cancer has significant impact on individuals and healthcare systems. Many genes have been identified to influence its pathogenesis. However, the genetic basis of mucinous tumor histology, an aggress...

    Authors: Michelle E. Penney, Patrick S. Parfrey, Sevtap Savas and Yildiz E. Yilmaz

    Citation: Biomarker Research 2018 6:17

    Content type: Research

    Published on:

  39. Calretinin is the most widespread positive marker for the immunohistochemical identification of malignant mesothelioma (MM) and was proposed to serve as a blood-based biomarker. Functionally, evidence has accu...

    Authors: Walter Blum, Thomas Henzi, Hugues-Etienne Châtel-Soulet, Laszlo Pecze, Janine Wörthmüller Rodriguez, Bart Vrugt and Beat Schwaller

    Citation: Biomarker Research 2018 6:19

    Content type: Short report

    Published on:

  40. Despite tremendous research efforts focused on diagnosis and treatment, pancreatic ductal adenocarcinoma remains the third leading cause of cancer-related death in the United States, with a 5-year overall surv...

    Authors: Shixiang Guo, Andrew Fesler, Huaizhi Wang and Jingfang Ju

    Citation: Biomarker Research 2018 6:18

    Content type: Review

    Published on:

  41. Germline mutations in the RUNX1 transcription factor give rise to a rare autosomal dominant genetic condition classified under the entity: Familial Platelet Disorders with predisposition to Acute Myeloid Leukaemi...

    Authors: Isaac KS Ng, Joanne Lee, Christopher Ng, Bustamin Kosmo, Lily Chiu, Elaine Seah, Michelle Meng Huang Mok, Karen Tan, Motomi Osato, Wee-Joo Chng, Benedict Yan and Lip Kun Tan

    Citation: Biomarker Research 2018 6:16

    Content type: Case report

    Published on:

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