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  1. Toll-like receptors (TLRs) are a large family of proteins that are expressed in immune cells and various tumor cells. TLR7/8 are located in the intracellular endosomes, participate in tumor immune surveillance...

    Authors: Hao Sun, Yingmei Li, Peng Zhang, Haizhou Xing, Song Zhao, Yongping Song, Dingming Wan and Jifeng Yu
    Citation: Biomarker Research 2022 10:89
  2. Rates of endometrial cancer (EC) are increasing. For a definitive diagnosis, women undergo various time-consuming and painful medical procedures, such as endometrial biopsy with or without hysteroscopy, and di...

    Authors: Paweł Łaniewski, Haiyan Cui, Nichole D. Mahnert, Jamal Mourad, Matthew P. Borst, Lyndsay Willmott, Dana M. Chase, Denise J. Roe and Melissa M. Herbst-Kralovetz
    Citation: Biomarker Research 2022 10:88
  3. HCC is a major health concern worldwide. PKC gamma, a member of the conventional PKC subclass, is involved in many cancer types, but the protein has received little attention in the context of single nucleotid...

    Authors: Fizzah Abid, Talha Iqbal, Khushbukhat Khan, Yasmin Badshah, Janeen H Trembley, Naeem Mahmood Ashraf, Maria Shabbir, Tayyaba Afsar, Ali Almajwal and Suhail Razak
    Citation: Biomarker Research 2022 10:87
  4. Chimeric antigen receptor T (CAR-T) cell therapy has significantly improved the life expectancy for patients with refractory or relapse B cell lymphoma. As for B cell acute lymphoblastic leukemia (B-ALL), alt...

    Authors: Yue Liu, Lingna An, Ruihao Huang, Jingkang Xiong, Haoyu Yang, Xiaoqi Wang and Xi Zhang
    Citation: Biomarker Research 2022 10:86
  5. Children with birth defects (BD) are more likely to develop cancer and the increased risk of cancer persists into adulthood. Prior population-based assessments have demonstrated that even non-chromosomal BDs a...

    Authors: Yichuan Liu, Hui-Qi Qu, Xiao Chang, Frank D Mentch, Haijun Qiu, Kenny Nguyen, Xiang Wang, Amir Hossein Saeidian, Deborah Watson, Joseph Glessner and Hakon Hakonarson
    Citation: Biomarker Research 2022 10:84
  6. Fluid protein biomarkers are important tools in clinical research and health care to support diagnosis and to monitor patients. Especially within the field of dementia, novel biomarkers could address the curre...

    Authors: Katharina Waury, Eline A. J. Willemse, Eugeen Vanmechelen, Henrik Zetterberg, Charlotte E. Teunissen and Sanne Abeln
    Citation: Biomarker Research 2022 10:83
  7. Shugoshin-like protein 2 (SGOL2) is a centromeric protein that ensures the correct and orderly process of mitosis by protecting and maintaining centripetal adhesions during meiosis and mitosis. Here, we examin...

    Authors: Qingqing Hu, Qiuhong Liu, Yalei Zhao, Lingjian Zhang and Lanjuan Li
    Citation: Biomarker Research 2022 10:82
  8. Esophageal adenocarcinoma is a lethal disease. For locally advanced patients, neoadjuvant chemoradiotherapy followed by surgery is the standard of care. Risk stratification relies heavily on clinicopathologic ...

    Authors: Hirsch Matani, Divya Sahu, Michael Paskewicz, Anastasia Gorbunova, Ashten N. Omstead, Rodney Wegner, Gene G. Finley, Blair A. Jobe, Ronan J. Kelly, Ali H. Zaidi and Ajay Goel
    Citation: Biomarker Research 2022 10:81
  9. BRCAness is a characteristic feature of homologous recombination deficiency (HRD) mimicking BRCA gene mutation in breast cancer. We hypothesized that a measure to quantify BRCAness that causes synthetic lethal...

    Authors: Masanori Oshi, Shipra Gandhi, Rongrong Wu, Mariko Asaoka, Li Yan, Akimitsu Yamada, Shinya Yamamoto, Kazutaka Narui, Takashi Chishima, Takashi Ishikawa, Itaru Endo and Kazuaki Takabe
    Citation: Biomarker Research 2022 10:80
  10. A few critically short telomeres trigger genomic instability regardless of average telomere length (TL). Recently, the telomere shortest length assay (TeSLA) was developed to detect critically short telomeres ...

    Authors: Dong-Yeop Shin, Kyu Min Lim, Hee Sue Park, Sunghoon Kwon, Sung-Soo Yoon and Dong-Soon Lee
    Citation: Biomarker Research 2022 10:79
  11. Esophageal carcinoma is the highly lethal cancer in the world, predominantly in some areas of East Asia. We previously reported that overexpression of cytoskeleton regulator Wiskott-Aldrich syndrome protein an...

    Authors: Mengxing Guo, Jingyao Lian, Yaqing Liu, Bo Dong, Qianyi He, Qitai Zhao, Hongyan Zhang, Yu Qi, Yi Zhang and Lan Huang
    Citation: Biomarker Research 2022 10:77
  12. There is a growing body of evidence to support tears as a non-traditional biological fluid in clinical laboratory testing. In addition to the simplicity of tear fluid processing, the ability to access key canc...

    Authors: Anna Daily, Prashanth Ravishankar, Wanyi Wang, Ryan Krone, Steve Harms and V. Suzanne Klimberg
    Citation: Biomarker Research 2022 10:76
  13. Chronic lymphocytic leukemia (CLL) is a heterogeneous B-cell malignancy that lacks specific biomarkers and drug targets. Competing endogenous RNAs (ceRNAs) play vital roles in oncogenesis and tumor progression...

    Authors: Xin Zhang, Yang Han, Xinting Hu, Hua Wang, Zheng Tian, Ya Zhang and Xin Wang
    Citation: Biomarker Research 2022 10:75
  14. Gastrointestinal cancers (GICs) occupy more than 30% of the cancer-related incidence and mortality around the world. Despite advances in the treatment strategies, the long-term overall survival has not been im...

    Authors: Ya-ya Yu, Yan-juan Zhu, Zhen-zhen Xiao, Ya-dong Chen, Xue-song Chang, Yi-hong Liu, Qing Tang and Hai-bo Zhang
    Citation: Biomarker Research 2022 10:73
  15. MicroRNAs (miRNAs) are a class of small non-coding RNAs ranging from 17 to 25 nt in length. miR-637 is down-regulated in most cancers and up-regulated only in clear cell renal cell carcinoma (ccRCC). miR-637 c...

    Authors: Jinze Shen, Chenhao Liang, Xinming Su, Qurui Wang, Yufei Ke, Jie Fang, Dayong Zhang and Shiwei Duan
    Citation: Biomarker Research 2022 10:72
  16. Recently, the global incidence of gastric/gastroesophageal junction (G/GEJ) cancer has remained high. China is also a large country with a high gastric cancer (GC) incidence rate, where the cases of GC account...

    Authors: Weiling Li, Xiaoling Zhang, Yunyi Du, Ying Zhang, Jing Lu, Wenqing Hu and Jun Zhao
    Citation: Biomarker Research 2022 10:71
  17. Interferon-α2b (IFN-α2b) is a highly active cytokine that belongs to the interferon-α (IFN-α) family. IFN-α2b has beneficial antiviral, antitumour, antiparasitic and immunomodulatory activities. Direct and ind...

    Authors: Fei Xiong, Qi Wang, Guan-hua Wu, Wen-zheng Liu, Bing Wang and Yong-jun Chen
    Citation: Biomarker Research 2022 10:69
  18. Neuroblastoma (NBL) is the most common extra-cranial solid tumour in childhood, with prognosis ranging from spontaneous remission to high risk for rapid and fatal progression. Despite existing therapy approach...

    Authors: Ying Huang, Jieyi Ma, Cuiyun Yang, Paijia Wei, Minghui Yang, Hui Han, Hua Dong Chen, Tianfang Yue, Shu Xiao, Xuanyu Chen, Zuoqing Li, Yanlai Tang, Jiesi Luo, Shuibin Lin and Libin Huang
    Citation: Biomarker Research 2022 10:68
  19. Gastric cancer is characterized by high morbidity and mortality worldwide. Early-stage gastric cancer is mainly treated with surgery, while for advanced gastric cancer, the current treatment options remain ins...

    Authors: Hongzhen Cai, Man Li, Ruiyi Deng, Mopei Wang and Yanyan Shi
    Citation: Biomarker Research 2022 10:67
  20. Hepatocellular carcinoma (HCC) is a type of cancer that affects the liver and has a high mortality rate. Long non-coding RNAs (lncRNAs) dysregulation can contribute to cancer occurrence and progression, althou...

    Authors: Chen Su, Weijian Wang, Jie Mo, Furong Liu, Hongwei Zhang, Yachong Liu, Xiaoping Chen, Zhibin Liao, Bixiang Zhang and Peng Zhu
    Citation: Biomarker Research 2022 10:65
  21. Circular RNAs (circRNAs) are important regulators of the development and progression of non-small-cell lung cancer (NSCLC) and many other malignancies. The functional importance of circ_0009043 in NSCLC, howev...

    Authors: Kelin She, Shaoqi Yu, Shushuai He, Wen Wang and Biao Chen
    Citation: Biomarker Research 2022 10:61
  22. Esophageal squamous cell carcinoma (ESCC) represents a major malignancy with poor clinical outcomes. Long noncoding RNAs (lncRNAs) are known to regulate the development and progression of multiple cancers. How...

    Authors: Yuhang Xiao, Jinming Tang, Desong Yang, Baihua Zhang, Jie Wu, Zhining Wu, Qianjin Liao, Hui Wang, Wenxiang Wang and Min Su
    Citation: Biomarker Research 2022 10:60
  23. Liver cancer is one of the most common malignant tumors worldwide, it is ranked sixth in incidence and fourth in mortality. According to the distinct origin of malignant tumor cells, liver cancer is mainly div...

    Authors: Hao Peng, Erwei Zhu and Yewei Zhang
    Citation: Biomarker Research 2022 10:59
  24. Circulating tumor cells (CTCs) are cells that shed from a primary tumor and travel through the bloodstream. Studying the functional and molecular characteristics of CTCs may provide in-depth knowledge regardin...

    Authors: Siwei Ju, Cong Chen, Jiahang Zhang, Lin Xu, Xun Zhang, Zhaoqing Li, Yongxia Chen, Jichun Zhou, Feiyang Ji and Linbo Wang
    Citation: Biomarker Research 2022 10:58
  25. Intercellular communication is mediated by extracellular vesicles (EVs), as they enclose selectively packaged biomolecules that can be horizontally transferred from donor to recipient cells. Because all cells ...

    Authors: Diogo Fortunato, Stavros Giannoukakos, Ana Giménez-Capitán, Michael Hackenberg, Miguel A. Molina-Vila and Nataša Zarovni
    Citation: Biomarker Research 2022 10:57
  26. Prostate cancer (PC) is a common tumor in men, and the incidence rate is high worldwide. Exosomes are nanosized vesicles released by all types of cells into multiple biological fluid types. These vesicles cont...

    Authors: Xiaolin Cui, Qiang Fu, Xueying Wang, Pengcheng Xia, Xianglun Cui, Xiaohui Bai and Zhiming Lu
    Citation: Biomarker Research 2022 10:56
  27. Circulating tumour DNA (ctDNA)-based sequencing might provide a simple test for the stratified model of non-small cell lung cancer (NSCLC). Here, we aimed to assess the ctDNA sequencing-based tumour mutation i...

    Authors: Jun Lu, Jun Wu, Yuqing Lou, Qin Shi, Jun Xu, Lele Zhang, Wei Nie, Jie Qian, Yanan Wang, Yanwei Zhang, Jing Jiao, Xueyan Zhang, Wei Zhang, Huimin Wang, Tianqing Chu, Hua Zhong…
    Citation: Biomarker Research 2022 10:55
  28. In our previous study, we found that lncRNA TRAF3IP2 antisense RNA 1 (TRAF3IP2-AS1) could play a critical role in the progression of NONO-TFE3 translocation renal cell carcinoma (NONO-TFE3 tRCC). However, the fun...

    Authors: Lei Yang, Yi Chen, Ning Liu, Yanwen Lu, Xin Li, Wenliang Ma, Weidong Gan and Dongmei Li
    Citation: Biomarker Research 2022 10:54
  29. Nasopharyngeal carcinoma (NPC) is one of the most common malignant tumours of the head and neck in Southeast Asia and southern China. The Phosphatidylinositol 3-kinase/protein kinase B (AKT)/mammalian target o...

    Authors: Hai-Long LI, Nian-Hua Deng, Xiu-Sheng He and Yue-Hua Li
    Citation: Biomarker Research 2022 10:52
  30. Diffuse large B-cell lymphoma (DLBCL) is an aggressive lymphoma with variable clinical outcomes and prediction of prognosis remains important for long-term remission. We performed serial serum soluble interleu...

    Authors: Yu-Jia Huo, Peng-Peng Xu, Li Wang, Hui-Juan Zhong, Di Fu, Qing Shi, Shu Cheng, Shuo Wang, Mu-Chen Zhang and Wei-Li Zhao
    Citation: Biomarker Research 2022 10:51
  31. As one of the leading causes of death, hematologic malignancies are associated with an ever-increasing incidence, and drug resistance and relapse of patients after treatment represent clinical challenges. Ther...

    Authors: Fahua Deng, Chengsi Zhang, Tingting Lu, Ezhong Joshua Liao, Hai Huang and Sixi Wei
    Citation: Biomarker Research 2022 10:50
  32. Immunotherapy has become the major treatment for tumors in clinical practice, but some intractable problems such as the low response rate and high rates of immune-related adverse events still hinder the progre...

    Authors: Xi-Yang Tang, Yan-Lu Xiong, Xian-Gui Shi, Ya-Bo Zhao, An-Ping Shi, Kai-Fu Zheng, Yu-Jian Liu, Tao Jiang, Nan Ma and Jin-Bo Zhao
    Citation: Biomarker Research 2022 10:49
  33. Docetaxel (DTX) is the most widely prescribed first-line chemotherapy for advanced prostate cancer (PCa). Unfortunately, DTX resistance invariably emerges, leading to worse prognosis of PCa. Growing evidence h...

    Authors: Haoli Yin, Haixiang Qin, Lei Yang, Mengxia Chen, Yang Yang, Wenlong Zhang, Jiange Hao, Qun Lu, Jingyan Shi, Junlong Zhuang, Xuefeng Qiu and Hongqian Guo
    Citation: Biomarker Research 2022 10:48
  34. Immunotherapy using programmed cell death 1 (PD1) inhibitors has shown great efficacy in colorectal cancer patients harboring mismatch-repair-deficient (dMMR) and microsatellite instability-high (MSI-H) altera...

    Authors: Hui Meng, Wu Yao, Yuhui Yin, Yizhen Li, Yi Ding, Liang Wang and Mingzhi Zhang
    Citation: Biomarker Research 2022 10:47
  35. T-cell lymphoma (TCL) is an aggressive and genetically heterogeneous malignancy with adverse clinical outcomes; thus, it is worth exploring biomarkers for risk stratification. Previous studies have demonstrate...

    Authors: Cunte Chen, Shaohua Chen, Gengxin Luo, Liang Wang, Chengwu Zeng, Grzegorz K. Przybylski and Yangqiu Li
    Citation: Biomarker Research 2022 10:46
  36. Pediatric low-grade gliomas (pLGGs), particularly incompletely resected supratentorial tumours, can undergo progression after surgery. However to date, there are no predictive biomarkers for progression. Here,...

    Authors: Giuseppina Catanzaro, Zein Mersini Besharat, Andrea Carai, Natalie Jäger, Elena Splendiani, Carole Colin, Agnese Po, Martina Chiacchiarini, Anna Citarella, Francesca Gianno, Antonella Cacchione, Evelina Miele, Francesca Diomedi Camassei, Marco Gessi, Luca Massimi, Franco Locatelli…
    Citation: Biomarker Research 2022 10:44
  37. Immunotherapy of acute myeloid leukemia has experienced considerable advances, however novel target antigens continue to be sought after. To this end, unbiased approaches for surface protein detection are lim...

    Authors: Thomas Köhnke, Xilong Liu, Sascha Haubner, Veit Bücklein, Gerulf Hänel, Christina Krupka, Victor Solis-Mezarino, Franz Herzog and Marion Subklewe
    Citation: Biomarker Research 2022 10:43
  38. YAP1 (Yes-associated protein 1) is one of the principal factors that mediates oncogenesis by acting as a driver of gene expression. It has been confirmed to play an important role in organ volume control, stem...

    Authors: Haofeng Wu, Yachong Liu, Zhibin Liao, Jie Mo, Qiaofeng Zhang, Bixiang Zhang and Lei Zhang
    Citation: Biomarker Research 2022 10:42
  39. Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive gastrointestinal cancers with high incidence and mortality. Therefore, it is necessary to identify novel sensitive and specific biomarker...

    Authors: Chenxi Ju, Jing He, Chang Wang, Jinxiu Sheng, Jinlin Jia, Dan Du, Hongle Li, Mingxia Zhou and Fucheng He
    Citation: Biomarker Research 2022 10:41
  40. Thyroid cancer (TC) is one of the most frequent endocrine malignancies that is more common among females. Tumor recurrence is one of the most important clinical manifestations in differentiated TC which is ass...

    Authors: Amir Abbas Hamidi, Negin Taghehchian, Zahra Basirat, Amir Sadra Zangouei and Meysam Moghbeli
    Citation: Biomarker Research 2022 10:40

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