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  1. Defect in DNA damage response (DDR) is a common feature of cancer cells, which regulates tumor growth and therapeutic response. Recently, the approval of immune checkpoint blockade (ICB) for tumors with defect...

    Authors: Jing Zhang, David J. H. Shih and Shiaw-Yih Lin

    Citation: Biomarker Research 2020 8:23

    Content type: Review

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  2. The KRAS mutation is the second most common genetic variant in Chinese non-small cell lung cancer (NSCLC) patients. At the 2019th World Conference of Lung Cancer, the KRAS G12C-specific inhibitor AMG510 showed pr...

    Authors: Si-Yang Liu, Hao Sun, Jia-Ying Zhou, Guang-Ling Jie, Zhi Xie, Yang Shao, Xian Zhang, Jun-Yi Ye, Chun-Xiang Chen, Xu-Chao Zhang, Qing Zhou, Jin-Ji Yang and Yi-Long Wu

    Citation: Biomarker Research 2020 8:22

    Content type: Research

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  3. Lysyl oxidase (LOX) has been described as necessary for premetastatic niche formation in epithelium-derived malignancies and its expression level therefore correlates with risk of metastatic disease and overal...

    Authors: Desiree Kunadt, Michael Kramer, Claudia Dill, Heidi Altmann, Lisa Wagenführ, Brigitte Mohr, Christian Thiede, Christoph Röllig, Johannes Schetelig, Martin Bornhäuser, Markus Schaich and Friedrich Stölzel

    Citation: Biomarker Research 2020 8:20

    Content type: Research

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  4. Chimeric antigen receptor T cells (CAR-T cells) therapy has been well recognized for treating B cell-derived malignancy. However, the efficacy of CAR-T cells against solid tumors remains dissatisfactory, parti...

    Authors: Le Qin, Ruocong Zhao, Dongmei Chen, Xinru Wei, Qiting Wu, Youguo Long, Zhiwu Jiang, Yangqiu Li, Haipeng Wu, Xuchao Zhang, Yilong Wu, Shuzhong Cui, Wei Wei, Huihui Yao, Zixia Liu, Su Cao…

    Citation: Biomarker Research 2020 8:19

    Content type: Research

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  5. Chimeric antigen receptor (CAR) T cell therapy, especially anti-CD19 CAR T cell therapy, has shown remarkable anticancer activity in patients with relapsed/refractory acute lymphoblastic leukemia, demonstratin...

    Authors: Yuru Nie, Weiqing Lu, Daiyu Chen, Huilin Tu, Zhenling Guo, Xuan Zhou, Meifang Li, Sanfang Tu and Yuhua Li

    Citation: Biomarker Research 2020 8:18

    Content type: Review

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  6. Acute myeloid leukemia (AML) is a clonal malignancy characterized by genetic heterogeneity due to recurrent gene mutations. Treatment with cytotoxic chemotherapy has been the standard of care for more than hal...

    Authors: Jifeng Yu, Peter Y. Z. Jiang, Hao Sun, Xia Zhang, Zhongxing Jiang, Yingmei Li and Yongping Song

    Citation: Biomarker Research 2020 8:17

    Content type: Review

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  7. For the detection of malignant mesothelioma additional markers are needed besides the established panel consisting of calretinin and mesothelin. The aim of this study was the identification and verification of...

    Authors: Daniel G. Weber, Swaantje Casjens, Alexander Brik, Irina Raiko, Martin Lehnert, Dirk Taeger, Jan Gleichenhagen, Jens Kollmeier, Torsten T. Bauer, Thomas Brüning and Georg Johnen

    Citation: Biomarker Research 2020 8:15

    Content type: Research

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  8. Treatment with chimeric antigen receptor (CAR)-engineered T cells directed against the B-cell maturation antigen (BCMA) promoted transient recovery from multiple myeloma (MM). However, the absence of this anti...

    Authors: Liqing Kang, Jian Zhang, Minghao Li, Nan Xu, Wei Qi, Jingwen Tan, Xiaoyan Lou, Zhou Yu, Juanjuan Sun, Zhenkun Wang, Chengcheng Fu, Xiaowen Tang, Haiping Dai, Jia Chen, Depei Wu and Lei Yu

    Citation: Biomarker Research 2020 8:14

    Content type: Research

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  9. Extramedullary relapse is an important cause of treatment failure among patients with acute lymphoblastic leukemia (ALL). This type of relapse is commonly observed in the central nervous system, while it is ra...

    Authors: Ze-Fa Liu, Li-Yun Chen, Jin Wang, Li-qing Kang, Hua Tang, Yao Zhou, Hai-Xia Zhou, Ai-Ning Sun, De-Pei Wu and Sheng-Li Xue

    Citation: Biomarker Research 2020 8:12

    Content type: Case report

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  10. The poor response to current PD-1/PD-L1 inhibitors in lung cancer patients requires development of novel immunotargets. Immunoglobulin-like transcript (ILT)4 is an immunosuppressive molecule mainly expressed i...

    Authors: Qing Li, Juan Li, Shuyun Wang, Jingnan Wang, Xiaozheng Chen, Dongmei Zhou, Yuying Fang, Aiqin Gao and Yuping Sun

    Citation: Biomarker Research 2020 8:11

    Content type: Research

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  11. Primary testicular lymphoma (PTL), often appearing as focal masses in the scrotum and epididymides, is the most frequent testicular tumor in aged men. Although MYD88 and CD79B mutations were the most common ge...

    Authors: Xinfeng Wang, Xiaoyu Xu, Wenzhi Cai, Haiyan Bao, Hongming Huang, Yifei Liu, Xi Yang, Changgeng Ruan, Depei Wu, Hongjie Shen and Suning Chen

    Citation: Biomarker Research 2020 8:10

    Content type: Letter to the Editor

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  12. High tumor mutation burden (TMB), which is associated with increased tumor immunogenicity, has been identified to predict improved response to immune checkpoint inhibitors (ICIs) therapy in non-small cell lung...

    Authors: Yongfeng Wu, Jinming Xu, Jiawei Xu, Yiqing Wang, Luming Wang, Wang Lv and Jian Hu

    Citation: Biomarker Research 2020 8:9

    Content type: Letter to the Editor

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  13. The prognosis of colorectal cancer (CRC) is still challenging to evaluate or predict. Recently, long non-coding RNAs (lncRNAs) have been found to play an important role in tumorigenesis and prognosis, however,...

    Authors: Rui Huang, Lian Zhou, Yue Chi, Haibo Wu and Lei Shi

    Citation: Biomarker Research 2020 8:8

    Content type: Research

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  14. MiRNAs have been widely reported as the therapeutic target for hepatocellular carcinoma (HCC). However, mirna clusters, as the more impressive tumor regulatory factors, have received little attention. By deepl...

    Authors: Tao Rui, Siyi Xu, Shi Feng, Xueyou Zhang, Haitao Huang and Qi Ling

    Citation: Biomarker Research 2020 8:7

    Content type: Letter to the Editor

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  15. Altered expression of T cell immune inhibitory receptors may result in immunosuppression and associate with the poor prognosis of leukemia patients in which the leukemic bone marrow (BM) microenvironment may c...

    Authors: Jiaxiong Tan, Zhi Yu, Jingying Huang, Youchun Chen, Shuxin Huang, Danlin Yao, Ling Xu, Yuhong Lu, Shaohua Chen and Yangqiu Li

    Citation: Biomarker Research 2020 8:6

    Content type: Research

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  16. We used the Toponome Imaging System (TIS) to identify “patterns of marker expression”, referred to here as combinatorial molecular phenotypes (CMPs) in alveolar macrophages (AM) in response to the innate immun...

    Authors: David S. Phelps, Vernon M. Chinchilli, Judith Weisz, Debra Shearer, Xuesheng Zhang and Joanna Floros

    Citation: Biomarker Research 2020 8:5

    Content type: Research

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  17. The MER signaling pathway represents an attractive therapeutic target for human cancers. Growth arrest–specific protein 6 (GAS6)–induced MER phosphorylation is often unstable and difficult to detect without pe...

    Authors: Yaoyu Chen, Margaret Favata, Michelle Pusey, Jun Li, Yvonne Lo, Min Ye, Richard Wynn, Xiaozhao Wang, Wenqing Yao and Yingnan Chen

    Citation: Biomarker Research 2020 8:4

    Content type: Research

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  18. Gastric cancer is a deadly malignancy and is a prognostically unfavorable entity with restricted therapeutic strategies available. Prostate stem cell antigen (PSCA) is a glycosylphosphatidylinositol (GPI)-anch...

    Authors: Di Wu, Jiang Lv, Ruocong Zhao, Zhiping Wu, Diwei Zheng, Jingxuan Shi, Simiao Lin, Suna Wang, Qiting Wu, Youguo Long, Peng Li and Yao Yao

    Citation: Biomarker Research 2020 8:3

    Content type: Research

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  19. Thalidomide, lenalidomide and pomalidomide are immunomodulatory drugs (IMiDs) effective in the treatment of multiple myeloma, myelodysplastic syndrome (MDS) with deletion of chromosome 5q and other hematologic...

    Authors: Shaobing Gao, Shichao Wang and Yongping Song

    Citation: Biomarker Research 2020 8:2

    Content type: Review

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  20. Malignant pleural mesothelioma (MPM) is a rare and aggressive cancer that develops in the pleural and outer layer of tissues surrounding the lungs. MPM is primarily caused by occupational exposure to asbestos ...

    Authors: Min-Kyu Kim, Hyun-won Kim, Mirae Jang, Sung Soo Oh, Suk-Joong Yong, Yangsik Jeong, Soon-Hee Jung and Jong-Whan Choi

    Citation: Biomarker Research 2020 8:1

    Content type: Research

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  21. Immunotherapy is currently under investigation in B3 Thymoma (TB3) and Thymic Carcinoma (TC). PD-L1 expression has been evaluated on a limited number of patients with selected antibodies. We aimed to analyze c...

    Authors: Isabelle Rouquette, Estelle Taranchon-Clermont, Julia Gilhodes, Maria-Virginia Bluthgen, Romain Perallon, Lara Chalabreysse, Anne De Muret, Veronique Hofman, Alexander Marx, Marie Parrens, Veronique Secq, Vincent Thomas de Montpreville, Françoise Galateau-Salle, Pierre Brousset, Julie Milia, Nicolas Girard…

    Citation: Biomarker Research 2019 7:28

    Content type: Research

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  22. Tamoxifen treatment has previously been reported to confer life-prolonging effects in patients with advanced pancreatic cancer, and most evidently so in women. None of these trials did however include biomarke...

    Authors: Gustav Andersson, Sebastian Lundgren, Margareta Heby, Björn Nodin, Jacob Elebro and Karin Jirström

    Citation: Biomarker Research 2019 7:26

    Content type: Research

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  23. Tumor-associated antigens (TAA) or cancer biomarkers are major targets for cancer therapies. Antibody- based agents targeting the cancer biomarkers include monoclonal antibodies (MoAbs), radiolabeled MoAbs, bi...

    Authors: Delong Liu

    Citation: Biomarker Research 2019 7:25

    Content type: Editorial

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  24. Phenotypic and functional heterogeneity is one of the hallmarks of human cancers. Tumor genotype variations among tumors within different patients are known as interpatient heterogeneity, and variability among...

    Authors: Mingzhou Guo, Yaojun Peng, Aiai Gao, Chen Du and James G. Herman

    Citation: Biomarker Research 2019 7:23

    Content type: Review

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  25. The original article [1] contains an error in the legend of Fig. 1 whereby it is incorrectly stated that MEC stands for ‘mitoprostate cancer using magnetic resonance imagingxantrone, etoposide, cyclophosphamid...

    Authors: Juanjuan Zhao, Yongping Song and Delong Liu

    Citation: Biomarker Research 2019 7:21

    Content type: Correction

    Published on:

    The original article was published in Biomarker Research 2019 7:19

  26. This study evaluated breast tissue stiffness measured by ultrasound elastography and the percent breast density measured by magnetic resonance imaging to understand their relationship.

    Authors: Jeon-Hor Chen, Siwa Chan, Yang Zhang, Shunshan Li, Ruey-Feng Chang and Min-Ying Su

    Citation: Biomarker Research 2019 7:20

    Content type: Research

    Published on:

  27. FMS-like tyrosine kinase 3- internal tandem duplication (FLT3-ITD) remains as one of the most frequently mutated genes in acute myeloid leukemia (AML), especially in those with normal cytogenetics. The FLT3-IT...

    Authors: Juanjuan Zhao, Yongping Song and Delong Liu

    Citation: Biomarker Research 2019 7:19

    Content type: Review

    Published on:

    The Correction to this article has been published in Biomarker Research 2019 7:21

  28. CAR-T cell therapy targeting CD19 has achieved remarkable success in the treatment of B cell malignancies, while various solid malignancies are still refractory for lack of suitable target. In recent years, a ...

    Authors: Jiang Lv and Peng Li

    Citation: Biomarker Research 2019 7:18

    Content type: Review

    Published on:

  29. The peroxiredoxins (PRDXs) gene family has been demonstrated to participate in carcinogenesis and development of numerous cancers and the prognostic values in several cancers have been evaluated already. Purpo...

    Authors: Jie Mei, Leiyu Hao, Xiaorui Liu, Guangshun Sun, Rui Xu, Huiyu Wang and Chaoying Liu

    Citation: Biomarker Research 2019 7:16

    Content type: Research

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  30. The discovery of JAK2V617F and the demonstration that BCR-ABL-negative myeloproliferative neoplasms (MPNs) are driven by abnormal JAK2 activation have led to advances in diagnostic algorithms, prognosis and ultim...

    Authors: Bing Li, Raajit K. Rampal and Zhijian Xiao

    Citation: Biomarker Research 2019 7:15

    Content type: Review

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  31. The epidermal growth factor receptor (EGFR) monoclonal IgG1 antibody cetuximab is approved for first-line treatment of recurrent and metastatic (R/M) HNSCC as a part of the standard of care EXTREME regimen (plati...

    Authors: Madelyn Espinosa-Cotton, Elana J. Fertig, Laura P. Stabile, Autumn Gaither-Davis, Julie E. Bauman, Sandra Schmitz, Katherine N. Gibson-Corley, Yinwen Cheng, Isaac J. Jensen, Vladimir P. Badovinac, Douglas Laux and Andrean L. Simons

    Citation: Biomarker Research 2019 7:14

    Content type: Research

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  32. The MPL protein is a major regulator of megakaryopoiesis and platelet formation as well as stem cell regulation. Aberrant MPL and downstream Jak/STAT signaling results in the development of the Myeloproliferat...

    Authors: Boguslaw A. Kwiatkowski, Nicolas R. Burwick and Robert E. Richard

    Citation: Biomarker Research 2019 7:13

    Content type: Research

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  33. We previously identified a TCR Vβ21 T cell clone which was specific to CML patients, and demonstrated that TCR Vα13/β21 gene-modified CD3+ T cells had specific cytotoxicity for HLA-A11+ K562 cells. However, it re...

    Authors: Yikai Zhang, Ling Xu, Shaohua Chen, Xianfeng Zha, Wei Wei and Yangqiu Li

    Citation: Biomarker Research 2019 7:12

    Content type: Short report

    Published on:

  34. Changes in DNA methylation over the course of life may provide an indicator of risk for cancer. We explored longitudinal changes in CpG methylation from blood leukocytes, and likelihood of future cancer diagno...

    Authors: Alexandra H. Bartlett, Jane W. Liang, Jose Vladimir Sandoval-Sierra, Jay H. Fowke, Eleanor M. Simonsick, Karen C. Johnson and Khyobeni Mozhui

    Citation: Biomarker Research 2019 7:10

    Content type: Research

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  35. Early neurological deterioration (END) is common after stroke. Prediction could identify patients requiring additional monitoring and intervention. Purines, breakdown products of adenosine triphosphate which a...

    Authors: Alexander J. Martin, Nicholas Dale, Christopher H. E. Imray, Christine Roffe, Craig J. Smith, Faming Tian and Christopher I. Price

    Citation: Biomarker Research 2019 7:7

    Content type: Research

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  36. Mesenchymal stromal cells (MSC) are a heterogeneous cell population with self-renewal and the ability to differentiate into different lineages. The novel regulatory role of MSC in both adaptive and innate immu...

    Authors: Peilong Lai, Jianyu Weng, Liyan Guo, Xiaomei Chen and Xin Du

    Citation: Biomarker Research 2019 7:6

    Content type: Review

    Published on:

  37. Barrett’s esophagus (BE) and esophageal adenocarcinoma (EAC) incidence has been increasing in the United States for greater than 30 years. For the majority of EAC patients, treatment is limited and prognosis p...

    Authors: Emily M. Christman, Parthasarathy Chandrakesan, Nathaniel Weygant, John T. Maple, William M. Tierney, Kenneth J. Vega and Courtney W. Houchen

    Citation: Biomarker Research 2019 7:5

    Content type: Short report

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  38. In current clinical practice, Serum Creatinine (SCr) is a commonly used marker for the diagnosis of acute kidney injury (AKI). Unfortunately, due to a delayed increase in SCr, it is unable to accurately estima...

    Authors: Shabnum Khawaja, Lena Jafri, Imran Siddiqui, Madiha Hashmi and Farooq Ghani

    Citation: Biomarker Research 2019 7:4

    Content type: Research

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  39. Chronic inflammatory demyelinating polyneuropathy (CIDP) is characterised by significant clinical heterogeneity and as such reliable biomarkers are required to measure disease activity and assess treatment res...

    Authors: Anthony Khoo, Joseph Frasca and David Schultz

    Citation: Biomarker Research 2019 7:3

    Content type: Review

    Published on:

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