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  1. Toll-like receptor 4 (TLR4) and its co-receptor CD14 play a major role in innate immunity by recognizing PAMPs and signal the activation of adaptive responses. These receptors can recognize endogenous ligands ...

    Authors: Tarak Dhaouadi, Imen Sfar, Youssra Haouami, Leila Abdelmoula, Sami Turki, Lamia Ben Hassine, Rafik Zouari, Adel Khedher, Narjess Khalfallah, Taieb Ben Abdallah and Yousr Gorgi

    Citation: Biomarker Research 2013 1:20

    Content type: Research

    Published on:

  2. Accumulated data from previous studies appear to suggest a link between the overexpression of a 35 kDa fragment of serum inter-alpha-trypsin inhibitor H4 (ITIH4) with cancers that are associated with up-regula...

    Authors: Emida Mohamed, Jaime Jacqueline Jayapalan, Puteri Shafinaz Abdul-Rahman, Siti Zawiah Omar and Onn Haji Hashim

    Citation: Biomarker Research 2013 1:19

    Content type: Research

    Published on:

  3. Nipple aspirate fluid (NAF) contains large amounts of protein thought to reflect the microenvironment of the breast, and is of interest in breast cancer prevention research. The correlation between specific NA...

    Authors: Jessica A Miller, Patricia A Thompson, Iman A Hakim, Ana Maria Lopez, Cynthia A Thomson, Chiu-Hsieh Hsu and H-H Sherry Chow

    Citation: Biomarker Research 2013 1:18

    Content type: Short report

    Published on:

  4. Insulin resistance associated with type 2 diabetes mellitus (T2DM), obesity, and atherosclerosis is a global health problem. A portfolio of abnormalities of metabolic and vascular homeostasis accompanies T2DM ...

    Authors: Fuyong Du, Anthony Virtue, Hong Wang and Xiao-Feng Yang

    Citation: Biomarker Research 2013 1:17

    Content type: Review

    Published on:

  5. Colorectal cancer remains one of the leading causes of death from cancer in industrialized countries. Integrins are a family of heterodimeric glycoproteins involved in bidirectional cell signaling and particip...

    Authors: Salah Boudjadi, Julie C Carrier and Jean-François Beaulieu

    Citation: Biomarker Research 2013 1:16

    Content type: Research

    Published on:

  6. The cyclin-dependent kinase inhibitor p27Kip1 functions during normal cerebellar development and has demonstrated tumor suppressor functions in mouse models of medulloblastoma. Because P27 loss is associated with...

    Authors: Beryl A Hatton, David W Ellison, Amar Gajjar, Marcel Kool, Matthew Fero and James M Olson

    Citation: Biomarker Research 2013 1:14

    Content type: Short report

    Published on:

  7. Endometrial cancer (EC) is the leading malignant tumor occurring in the female genital tract and some subtypes are highly invasive and metastatic. miRNAs are small non-coding RNAs that have a broad impact on c...

    Authors: Haiyan Zhai, Mihriban Karaayvaz, Peixin Dong, Noriaki Sakuragi and Jingfang Ju

    Citation: Biomarker Research 2013 1:12

    Content type: Research

    Published on:

  8. IK is a nuclear protein containing a unique domain named RED due to the presence of a repetitive arginine (R), aspartic (E), and glutamic acid (D) sequence. To date, the function of this protein remains largel...

    Authors: Liyan Hu, Feikun Yang, Xianan Liu, Dazhong Xu and Wei Dai

    Citation: Biomarker Research 2013 1:11

    Content type: Research

    Published on:

  9. Diabetic kidney disease is the leading cause of end-stage renal disease in developed and developing countries. Microalbuminuria is the gold standard for detection and prediction of diabetic kidney disease and ...

    Authors: Cheng Wang, CuiCui Li, WenYu Gong and Tanqi Lou

    Citation: Biomarker Research 2013 1:9

    Content type: Review

    Published on:

  10. Metabolic alteration is one of the hallmarks of carcinogenesis. We aimed to identify certain metabolic biomarkers for the early detection of pancreatic cancer (PC) using the transgenic PTEN-null mouse model. P...

    Authors: He N Xu, Shoko Nioka and Lin Z Li

    Citation: Biomarker Research 2013 1:6

    Content type: Research

    Published on:

  11. Despite several decades of intensive effort to improve the imaging techniques for lung cancer diagnosis and treatment, primary lung cancer is still the number one cause of cancer death in the United States and...

    Authors: Dong Xiang, Bicheng Zhang, Donald Doll, Kui Shen, Goetz Kloecker and Carl Freter

    Citation: Biomarker Research 2013 1:4

    Content type: Review

    Published on:

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