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  1. T-cell prolymphocytic leukemia (T-PLL) is a poor prognostic disease with very limited options of efficient therapies. Most patients are refractory to chemotherapies and despite high response rates after alemtu...

    Authors: Carlos Cuesta-Mateos, Patricia Fuentes, Alexandra Schrader, Raquel Juárez-Sánchez, Javier Loscertales, Tamara Mateu-Albero, Lorena Vega-Piris, Marina Espartero-Santos, Ana Marcos-Jimenez, Blanca Andrea Sánchez-López, Yaiza Pérez-García, Dennis Jungherz, Sebastian Oberbeck, Linus Wahnschaffe, Anna Kreutzman, Emma I. Andersson…
    Citation: Biomarker Research 2020 8:54
  2. New biomarkers are urgently needed to improve personalized treatment approaches for head and neck squamous cell carcinoma (HNSCC). Global DNA hypomethylation has wide-ranging functions in multistep carcinogene...

    Authors: Kiyoshi Misawa, Satoshi Yamada, Masato Mima, Takuya Nakagawa, Tomoya Kurokawa, Atsushi Imai, Daiki Mochizuki, Daichi Shinmura, Taiki Yamada, Junya Kita, Ryuji Ishikawa, Yuki Yamaguchi, Yuki Misawa, Takeharu Kanazawa, Hideya Kawasaki and Hiroyuki Mineta
    Citation: Biomarker Research 2020 8:53
  3. Screening across a multitude of normal and malignant tissues revealed an enhanced expression of lymphocyte antigen 6 superfamily member D (LY6D) in squamous epithelium and urothelium, as well as in malignancie...

    Authors: Nina Andersson, Johan Ohlsson, Sara Wahlin, Björn Nodin, Karolina Boman, Sebastian Lundgren and Karin Jirström
    Citation: Biomarker Research 2020 8:51
  4. Ferroptosis belongs to a novel form of regulated cell death. It is characterized by iron dependence, destruction of intracellular redox balance and non-apoptosis. And cellular structure and molecules level cha...

    Authors: Sipeng Zuo, Jie Yu, Hui Pan and Linna Lu
    Citation: Biomarker Research 2020 8:50
  5. Interferon-γ (IFN-γ) plays a key role in activation of cellular immunity and subsequently, stimulation of antitumor immune-response. Based on its cytostatic, pro-apoptotic and antiproliferative functions, IFN-...

    Authors: Dragica Jorgovanovic, Mengjia Song, Liping Wang and Yi Zhang
    Citation: Biomarker Research 2020 8:49
  6. China is a highly endemic area of chronic hepatitis B (CHB). The accuracy of existed noninvasive biomarkers including TE, APRI and FIB-4 for staging fibrosis is not high enough in Chinese cohort.

    Authors: Xiao-Jie Lu, Xiao-Jun Yang, Jing-Yu Sun, Xin Zhang, Zhao-Xin Yuan and Xiu-Hui Li
    Citation: Biomarker Research 2020 8:48
  7. To establish and validate a radiomics-based model for predicting liver cirrhosis in patients with hepatitis B virus (HBV) by using non-contrast computed tomography (CT).

    Authors: Jin-Cheng Wang, Rao Fu, Xue-Wen Tao, Ying-Fan Mao, Fei Wang, Ze-Chuan Zhang, Wei-Wei Yu, Jun Chen, Jian He and Bei-Cheng Sun
    Citation: Biomarker Research 2020 8:47
  8. Clinically relevant methods are not available that prioritize and validate potential therapeutic targets for individual tumors, from the vast amount of tumor descriptive expression data.

    Authors: Wen-Hsin Liu, Paulina Mrozek-Gorska, Anna-Katharina Wirth, Tobias Herold, Larissa Schwarzkopf, Dagmar Pich, Kerstin Völse, M. Camila Melo-Narváez, Michela Carlet, Wolfgang Hammerschmidt and Irmela Jeremias
    Citation: Biomarker Research 2020 8:46
  9. The canonical and non-canonical nuclear factor-kappaB (NF-κB) signaling pathways have key roles in cancer, but studies have previously evaluated only the association of canonical transcription factors and ovar...

    Authors: Demetra H. Hufnagel, Andrew J. Wilson, Jamie Saxon, Timothy S. Blackwell, Jaclyn Watkins, Dineo Khabele, Marta A. Crispens, Fiona E. Yull and Alicia Beeghly-Fadiel
    Citation: Biomarker Research 2020 8:45
  10. Aging and average life expectancy have been increasing at a rapid rate, while there is an exponential risk to suffer from brain-related frailties and neurodegenerative diseases as the population ages. Alzheime...

    Authors: Yuan-Yuan Chen, Min-Chang Wang, Yan-Ni Wang, He-He Hu, Qing-Quan Liu, Hai-Jing Liu and Ying-Yong Zhao
    Citation: Biomarker Research 2020 8:42
  11. Long non-coding RNAs (lncRNAs) represent an important class of RNAs comprising more than 200 nucleotides, which are produced by RNA polymerase II. Although lacking an open reading framework and protein-encodin...

    Authors: Yuhang Xiao, Ta Xiao, Wei Ou, Zhining Wu, Jie Wu, Jinming Tang, Bo Tian, Yong Zhou, Min Su and Wenxiang Wang
    Citation: Biomarker Research 2020 8:41
  12. Breast cancer, a malignant tumor originating from mammary epithelial tissue, is the most common cancer among women worldwide. Challenges facing the diagnosis and treatment of breast cancer necessitate the sear...

    Authors: Yujing Zhou and Xingdang Liu
    Citation: Biomarker Research 2020 8:39
  13. Prognostic factors for the Coronavirus disease 2019 (COVID1–9) are not well established. This study aimed to summarize the available data on the association between the severity of COVID-19 and common hematolo...

    Authors: Celestin Danwang, Francky Teddy Endomba, Jan René Nkeck, Dominic Leandry Angong Wouna, Annie Robert and Jean Jacques Noubiap
    Citation: Biomarker Research 2020 8:37
  14. Mixed phenotype acute leukemia (MPAL) is a rare leukemia and is regarded as a high-risk entity with a poor prognosis. Induction therapy of an acute lymphoblastic leukemia type or hybrid regimen and hematopoiet...

    Authors: Meng-Yun Li, Zhi-Hong Lin, Ming-Ming Hu, Li-Qing Kang, Xiao-xia Wu, Qi-wei Chen, Xin Kong, Jian Zhang, Hui-Ying Qiu and De-Pei Wu
    Citation: Biomarker Research 2020 8:36
  15. PD-1/PD-L1 blockade therapy is a promising cancer treatment strategy, which has revolutionized the treatment landscape of malignancies. Over the last decade, PD-1/PD-L1 blockade therapy has been trialed in a b...

    Authors: Jin-Yu Sun, Dengke Zhang, Songquan Wu, Min Xu, Xiao Zhou, Xiao-Jie Lu and Jiansong Ji
    Citation: Biomarker Research 2020 8:35
  16. Early progression after the first-line R-CHOP treatment leads to a very dismal outcome and necessitates alternative treatment for patients with diffuse large B-cell lymphoma (DLBCL). This study aimed to develo...

    Authors: Jialin Ma, Zheng Yan, Jiuyang Zhang, Wenping Zhou, Zhihua Yao, Haiying Wang, Junfeng Chu, Shuna Yao, Shuang Zhao, Peipei Zhang, Yuanlin Xu, Qingxin Xia, Jie Ma, Bing Wei, Shujun Yang, Kangdong Liu…
    Citation: Biomarker Research 2020 8:33
  17. The term “pharmacogenetics” is used to describe the study of variability in drug response due to heredity. It is associated with “gene – drug interactions”. Later on, the term “pharmacogenomics” has been intro...

    Authors: Nelly N. Miteva-Marcheva, Hristo Y. Ivanov, Dimitar K. Dimitrov and Vili K. Stoyanova
    Citation: Biomarker Research 2020 8:32
  18. Acute myeloid leukemia (AML) is a malignant hematological neoplasm of myeloid progenitor cells. Mutations of FLT3 in its tyrosine kinase domain (FLT3-TKD) are found in ~ 8% of patients with AML, with D835Y as ...

    Authors: Yao Guo, Honghua Sun, Dengyang Zhang, Yuming Zhao, Mingxia Shi, Ming Yang, Shu Xing, Xueqi Fu, Ting Bin, Bo Lu, Shunjie Wu, Xiaojun Xu, Xuesong Xu, Yun Chen and Zhizhuang Joe Zhao
    Citation: Biomarker Research 2020 8:30
  19. The recently updated European LeukemiaNet risk stratification guidelines combine cytogenetic abnormalities and genetic mutations to provide the means to triage patients with acute myeloid leukemia for optimal ...

    Authors: Era L. Pogosova-Agadjanyan, Anna Moseley, Megan Othus, Frederick R. Appelbaum, Thomas R. Chauncey, I-Ming L. Chen, Harry P. Erba, John E. Godwin, Isaac C. Jenkins, Min Fang, Mike Huynh, Kenneth J. Kopecky, Alan F. List, Jasmine Naru, Jerald P. Radich, Emily Stevens…
    Citation: Biomarker Research 2020 8:29
  20. Beyond hemostasis, thrombosis and wound healing, it is becoming increasingly clear that platelets play an integral role in inflammatory response and immune regulation. Platelets recognize pathogenic microorgan...

    Authors: Yufei Chen, Haoxuan Zhong, Yikai Zhao, Xinping Luo and Wen Gao
    Citation: Biomarker Research 2020 8:28
  21. The early detection of tumors upon initial diagnosis or during routine surveillance is important for improving survival outcomes. Here, we investigated the feasibility and clinical significance of circulating ...

    Authors: Qiong Li, Wei Zhang, Jiali Li, Jingkang Xiong, Jia Liu, Ting Chen, Qin Wen, Yunjing Zeng, Li Gao, Lei Gao, Cheng Zhang, Peiyan Kong, Xiangui Peng, Yao Liu, Xi Zhang and Jun Rao
    Citation: Biomarker Research 2020 8:27
  22. Alterations of genes encoding subunits of the BAF/PBAF complexes are among the most frequent gene aberrations in human cancer. Such alterations have been shown to have an impact on tumor microenvironnement and...

    Authors: Kevin Courtet, Yec’han Laizet, Carlo Lucchesi, Alban Bessede and Antoine Italiano
    Citation: Biomarker Research 2020 8:26
  23. Circular RNAs (circRNAs) are covalently linked RNAs that exhibit individual strand with a closed-loop framework compared with a conserving, steady and abundant linear counterpart. In recent years, as high-thro...

    Authors: Zhouxiao Li, Ye Cheng, Fan Wu, Liangliang Wu, Hongyong Cao, Qian Wang and Weiwei Tang
    Citation: Biomarker Research 2020 8:25
  24. Defect in DNA damage response (DDR) is a common feature of cancer cells, which regulates tumor growth and therapeutic response. Recently, the approval of immune checkpoint blockade (ICB) for tumors with defect...

    Authors: Jing Zhang, David J. H. Shih and Shiaw-Yih Lin
    Citation: Biomarker Research 2020 8:23
  25. The KRAS mutation is the second most common genetic variant in Chinese non-small cell lung cancer (NSCLC) patients. At the 2019th World Conference of Lung Cancer, the KRAS G12C-specific inhibitor AMG510 showed pr...

    Authors: Si-Yang Liu, Hao Sun, Jia-Ying Zhou, Guang-Ling Jie, Zhi Xie, Yang Shao, Xian Zhang, Jun-Yi Ye, Chun-Xiang Chen, Xu-Chao Zhang, Qing Zhou, Jin-Ji Yang and Yi-Long Wu
    Citation: Biomarker Research 2020 8:22
  26. Lysyl oxidase (LOX) has been described as necessary for premetastatic niche formation in epithelium-derived malignancies and its expression level therefore correlates with risk of metastatic disease and overal...

    Authors: Desiree Kunadt, Michael Kramer, Claudia Dill, Heidi Altmann, Lisa Wagenführ, Brigitte Mohr, Christian Thiede, Christoph Röllig, Johannes Schetelig, Martin Bornhäuser, Markus Schaich and Friedrich Stölzel
    Citation: Biomarker Research 2020 8:20
  27. Chimeric antigen receptor T cells (CAR-T cells) therapy has been well recognized for treating B cell-derived malignancy. However, the efficacy of CAR-T cells against solid tumors remains dissatisfactory, parti...

    Authors: Le Qin, Ruocong Zhao, Dongmei Chen, Xinru Wei, Qiting Wu, Youguo Long, Zhiwu Jiang, Yangqiu Li, Haipeng Wu, Xuchao Zhang, Yilong Wu, Shuzhong Cui, Wei Wei, Huihui Yao, Zixia Liu, Su Cao…
    Citation: Biomarker Research 2020 8:19
  28. Chimeric antigen receptor (CAR) T cell therapy, especially anti-CD19 CAR T cell therapy, has shown remarkable anticancer activity in patients with relapsed/refractory acute lymphoblastic leukemia, demonstratin...

    Authors: Yuru Nie, Weiqing Lu, Daiyu Chen, Huilin Tu, Zhenling Guo, Xuan Zhou, Meifang Li, Sanfang Tu and Yuhua Li
    Citation: Biomarker Research 2020 8:18
  29. Acute myeloid leukemia (AML) is a clonal malignancy characterized by genetic heterogeneity due to recurrent gene mutations. Treatment with cytotoxic chemotherapy has been the standard of care for more than hal...

    Authors: Jifeng Yu, Peter Y. Z. Jiang, Hao Sun, Xia Zhang, Zhongxing Jiang, Yingmei Li and Yongping Song
    Citation: Biomarker Research 2020 8:17
  30. For the detection of malignant mesothelioma additional markers are needed besides the established panel consisting of calretinin and mesothelin. The aim of this study was the identification and verification of...

    Authors: Daniel G. Weber, Swaantje Casjens, Alexander Brik, Irina Raiko, Martin Lehnert, Dirk Taeger, Jan Gleichenhagen, Jens Kollmeier, Torsten T. Bauer, Thomas Brüning and Georg Johnen
    Citation: Biomarker Research 2020 8:15
  31. Treatment with chimeric antigen receptor (CAR)-engineered T cells directed against the B-cell maturation antigen (BCMA) promoted transient recovery from multiple myeloma (MM). However, the absence of this anti...

    Authors: Liqing Kang, Jian Zhang, Minghao Li, Nan Xu, Wei Qi, Jingwen Tan, Xiaoyan Lou, Zhou Yu, Juanjuan Sun, Zhenkun Wang, Chengcheng Fu, Xiaowen Tang, Haiping Dai, Jia Chen, Depei Wu and Lei Yu
    Citation: Biomarker Research 2020 8:14
  32. Extramedullary relapse is an important cause of treatment failure among patients with acute lymphoblastic leukemia (ALL). This type of relapse is commonly observed in the central nervous system, while it is ra...

    Authors: Ze-Fa Liu, Li-Yun Chen, Jin Wang, Li-qing Kang, Hua Tang, Yao Zhou, Hai-Xia Zhou, Ai-Ning Sun, De-Pei Wu and Sheng-Li Xue
    Citation: Biomarker Research 2020 8:12
  33. The poor response to current PD-1/PD-L1 inhibitors in lung cancer patients requires development of novel immunotargets. Immunoglobulin-like transcript (ILT)4 is an immunosuppressive molecule mainly expressed i...

    Authors: Qing Li, Juan Li, Shuyun Wang, Jingnan Wang, Xiaozheng Chen, Dongmei Zhou, Yuying Fang, Aiqin Gao and Yuping Sun
    Citation: Biomarker Research 2020 8:11
  34. Primary testicular lymphoma (PTL), often appearing as focal masses in the scrotum and epididymides, is the most frequent testicular tumor in aged men. Although MYD88 and CD79B mutations were the most common ge...

    Authors: Xinfeng Wang, Xiaoyu Xu, Wenzhi Cai, Haiyan Bao, Hongming Huang, Yifei Liu, Xi Yang, Changgeng Ruan, Depei Wu, Hongjie Shen and Suning Chen
    Citation: Biomarker Research 2020 8:10
  35. High tumor mutation burden (TMB), which is associated with increased tumor immunogenicity, has been identified to predict improved response to immune checkpoint inhibitors (ICIs) therapy in non-small cell lung...

    Authors: Yongfeng Wu, Jinming Xu, Jiawei Xu, Yiqing Wang, Luming Wang, Wang Lv and Jian Hu
    Citation: Biomarker Research 2020 8:9
  36. The prognosis of colorectal cancer (CRC) is still challenging to evaluate or predict. Recently, long non-coding RNAs (lncRNAs) have been found to play an important role in tumorigenesis and prognosis, however,...

    Authors: Rui Huang, Lian Zhou, Yue Chi, Haibo Wu and Lei Shi
    Citation: Biomarker Research 2020 8:8
  37. MiRNAs have been widely reported as the therapeutic target for hepatocellular carcinoma (HCC). However, mirna clusters, as the more impressive tumor regulatory factors, have received little attention. By deepl...

    Authors: Tao Rui, Siyi Xu, Shi Feng, Xueyou Zhang, Haitao Huang and Qi Ling
    Citation: Biomarker Research 2020 8:7
  38. Altered expression of T cell immune inhibitory receptors may result in immunosuppression and associate with the poor prognosis of leukemia patients in which the leukemic bone marrow (BM) microenvironment may c...

    Authors: Jiaxiong Tan, Zhi Yu, Jingying Huang, Youchun Chen, Shuxin Huang, Danlin Yao, Ling Xu, Yuhong Lu, Shaohua Chen and Yangqiu Li
    Citation: Biomarker Research 2020 8:6
  39. We used the Toponome Imaging System (TIS) to identify “patterns of marker expression”, referred to here as combinatorial molecular phenotypes (CMPs) in alveolar macrophages (AM) in response to the innate immun...

    Authors: David S. Phelps, Vernon M. Chinchilli, Judith Weisz, Debra Shearer, Xuesheng Zhang and Joanna Floros
    Citation: Biomarker Research 2020 8:5

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