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  1. Cancer is a genetic disease; its development and metastasis depend on the function of many proteins. Human serum contains thousands of proteins; it is a window for the homeostasis of individual’s health. Many ...

    Authors: David L. Wang, Chuanguang Xiao, Guofeng Fu, Xing Wang and Liang Li
    Citation: Biomarker Research 2017 5:11
  2. Environmental Enteropathy (EE) is a subclinical condition caused by constant fecal-oral contamination and resulting in blunting of intestinal villi and intestinal inflammation. Of primary interest in the clini...

    Authors: Miao Lu, Jianhui Zhou, Caitlin Naylor, Beth D. Kirkpatrick, Rashidul Haque, William A. Petri Jr and Jennie Z. Ma
    Citation: Biomarker Research 2017 5:9
  3. The aim of this study was to validate previously described diagnostic and prognostic microRNA expression profiles in tissue samples from patients with pancreatic cancer and other periampullary cancers.

    Authors: Dan Calatayud, Christian Dehlendorff, Mogens K. Boisen, Jane Preuss Hasselby, Nicolai Aagaard Schultz, Jens Werner, Heike Immervoll, Anders Molven, Carsten Palnæs Hansen and Julia S. Johansen
    Citation: Biomarker Research 2017 5:8
  4. Diffuse large B-cell lymphoma (DLBCL) is the most common form of non-Hodgkin lymphoma. Rhabdomyosarcoma, the most common soft tissue sarcoma of childhood. makes up less than 1% of solid malignancies in adults ...

    Authors: M. D. Mathias, M. V. Ortiz, H. Magnan, S. R. Ambati, E. K. Slotkin, A. J. Chou, M. F. Walsh, K. Offit, C. Moskowitz, A. Kentsis and L. H. Wexler
    Citation: Biomarker Research 2017 5:7
  5. CD20 negative B cell non-Hodgkin lymphoma (NHL) is rare and accounts for approximately 1-2% of B cell lymphomas. CD20- negative NHL is frequently associated with extranodal involvement, atypical morphology, ag...

    Authors: Tasleem Katchi and Delong Liu
    Citation: Biomarker Research 2017 5:5
  6. Synovial sarcoma (SS) is an aggressive soft tissue sarcoma (STS) that typically occurs in the extremities near a joint. Metastatic disease is common and usually occurs in the lungs and lymph nodes. Surgical ma...

    Authors: Rosalia de Necochea-Campion, Lee M. Zuckerman, Hamid R. Mirshahidi, Shahrzad Khosrowpour, Chien-Shing Chen and Saied Mirshahidi
    Citation: Biomarker Research 2017 5:4
  7. Essential molecular pathways such as the MAPK pathway, NO system, or the influence of PIK3CA as an oncogene are known to regulate fundamental signalling networks. However, few knowledge about their role in the...

    Authors: Steffen Koerdt, Nadine Tanner, Niklas Rommel, Nils H. Rohleder, Gesche Frohwitter, Oliver Ristow, Klaus-Dietrich Wolff and Marco R. Kesting
    Citation: Biomarker Research 2017 5:3
  8. DNA methylation plays an important role in gene expression, chromatin stability, and genetic imprinting. In mammals, DNA methylation patterns are written and regulated by DNA methyltransferases (DNMTs), includ...

    Authors: Wu Zhang and Jie Xu
    Citation: Biomarker Research 2017 5:1
  9. Glucocorticoids (GCs) remain the first line treatment for almost all non-infectious inflammatory diseases, ranging from acute asthma to rheumatoid arthritis. However, across all conditions, patients have a var...

    Authors: Emily L. Williams, Madeleine L. Stimpson, Peter L. Collins, Doyo G. Enki, Ashish Sinha, Richard W. Lee and Ashwin D. Dhanda
    Citation: Biomarker Research 2016 4:26
  10. There is an urgent need for new anti-malaria drugs with broad therapeutic potential and novel mode of action, for effective treatment and to overcome emerging drug resistance. Plant-derived anti-malarials rema...

    Authors: Protus Arrey Tarkang, Regina Appiah-Opong, Michael F. Ofori, Lawrence S. Ayong and Alexander K. Nyarko
    Citation: Biomarker Research 2016 4:25
  11. Mild cognitive impairment (MCI) is an intermediate state between normal aging and dementia including Alzheimer’s disease. Early detection of dementia, and MCI, is a crucial issue in terms of secondary preventi...

    Authors: Mitsunori Kayano, Sayuri Higaki, Jun-ichi Satoh, Kenji Matsumoto, Etsuro Matsubara, Osamu Takikawa and Shumpei Niida
    Citation: Biomarker Research 2016 4:22
  12. It is crucial to develop new antischistosomal drugs since there is no vaccine and the whole world is relying on only a single drug for the treatment of schistosomiasis. One of the obstacles to the development ...

    Authors: Emmanuel Mouafo Tekwu, William Kofi Anyan, Daniel Boamah, Kofi Owusu Baffour-Awuah, Stephanie Keyetat Tekwu, Veronique Penlap Beng, Alexander Kwadwo Nyarko and Kwabena Mante Bosompem
    Citation: Biomarker Research 2016 4:21
  13. Pancreatic cancer is characterized as a disease with low survival and high mortality because of no effective diagnostic and therapeutic strategies available in clinic. Conventional clinical diagnostic methods ...

    Authors: Jing Huang, Jianzhou Liu, Kevin Chen-Xiao, Xuemei Zhang, W. N. Paul Lee, Vay Liang W. Go and Gary Guishan Xiao
    Citation: Biomarker Research 2016 4:20
  14. Population studies showed that patients with JAK2 V617F mutation had increased mortality, and increased risk of any cancer, hematologic cancer, and myeloproliferative disease.

    Authors: Kenneth G. Liu, Amit Verma, Olga Derman, Noah Kornblum, Murali Janakiram, Ira Braunschweig and Ramakrishna Battini
    Citation: Biomarker Research 2016 4:19
  15. Bone marrow sarcoidosis is extremely rare. The association between sarcoidosis and lymphoproliferative disorders has been previously speculated, although the diagnosis of sarcoidosis often precedes any hematol...

    Authors: John Gubatan, Xiaohui Wang, Abner Louissaint, Anuj Mahindra and John Vanderpool
    Citation: Biomarker Research 2016 4:18
  16. Extramedullary hematopoeisis (EMH) can occur in various physiological and pathologic states. The spleen is the most common site of EMH.

    Authors: Tasleem Katchi, Krishna Kolandaivel, Pallavi Khattar, Taliya Farooq, Humayun Islam and Delong Liu
    Citation: Biomarker Research 2016 4:17
  17. Acute myeloid leukemia (AML) is commonly characterized by several chromosomal abnormalities resulting in the formation of chimeric genes that play various roles in leukemogenesis. Translocations resulting in the

    Authors: Carlos A. Tirado, Ken Siangchin, David S. Shabsovich, Maryam Sharifian and Gary Schiller
    Citation: Biomarker Research 2016 4:16
  18. Chronic myeloid leukemia (CML) comprises ~3 % of pediatric leukemia. Although therapy with tyrosine kinase inhibitors (TKIs) is highly effective for CML, multiple factors have been identified as predictive of ...

    Authors: Margaret Lewen, Renee Gresh, Maria Queenan, Michele Paessler, Vinodh Pillai, Elizabeth Hexner, Dale Frank, Adam Bagg, Richard Aplenc, Emi Caywood and Gerald Wertheim
    Citation: Biomarker Research 2016 4:14
  19. Oxaliplatin induced peripheral neurotoxicity (OXIPN) is the major dose-limiting and long-lasting side effect of oxaliplatin. N-3 PUFAs have neuroprotective property via their effects on voltage-gated ion chann...

    Authors: Ali Esfahani, Mohammad hossein Somi, Hormoz Ayromlou, Alireza Nikanfar, Mohammad Asghari Jafarabadi, Bina Eftekhar Sadat and Zohreh Ghoreishi
    Citation: Biomarker Research 2016 4:13
  20. Diffuse large B-cell lymphoma (DLBCL) is an aggressive disease with variable clinical outcome, accounting for at least 25-30 % of adult non-Hodgkin lymphomas. Approximately one third of DLBCL patients are not ...

    Authors: Linn Reinholdt, Maria Bach Laursen, Alexander Schmitz, Julie Støve Bødker, Lasse Hjort Jakobsen, Martin Bøgsted, Hans Erik Johnsen and Karen Dybkær
    Citation: Biomarker Research 2016 4:12
  21. Reprogrammed metabolism is a new hallmark of cancer. In many types of cancer, most of the genes in the glycolytic pathway are overexpressed, reflecting an essential shift of metabolism during cancer developmen...

    Authors: Zhenyu Sun, Xiaofeng Chen, Gan. Wang, Liang Li, Guofeng Fu, Matthew Kuruc and Xing Wang
    Citation: Biomarker Research 2016 4:11
  22. There is an increasing amount of reports on IFITM1 (interferon-inducible transmembrane protein 1) in various malignancies. The aim of this study was to examine the expression of IFITM1 and its prognostic signi...

    Authors: David Borg, Charlotta Hedner, Alexander Gaber, Björn Nodin, Richard Fristedt, Karin Jirström, Jakob Eberhard and Anders Johnsson
    Citation: Biomarker Research 2016 4:10
  23. Disruption of alternative splicing in apoptotic factors has been associated to chronic lymphocytic leukemia among other cancers and hematological malignancies. The proapoptotic proteins Caspase-9 and PP2Acα ar...

    Authors: Leticia Domínguez-Berrocal, Xiguang Zhang, Jean Marc Zini, Jesús Fominaya, Angelita Rebollo and Jerónimo Bravo
    Citation: Biomarker Research 2016 4:9
  24. HER2 expression in breast cancer correlates with increased metastatic potential, higher tumor recurrence rates and improved response to targeted therapies. Fluorescence in situ hybridization (FISH) and immunohist...

    Authors: Elisabeth Hofmann, Rita Seeboeck, Nico Jacobi, Peter Obrist, Samuel Huter, Christian Klein, Kamil Oender, Christoph Wiesner, Harald Hundsberger and Andreas Eger
    Citation: Biomarker Research 2016 4:8
  25. Patients with common variable immunodeficiency (CVID) have an increased risk of developing lymphoproliferative diseases, including non-Hodgkins lymphoma (Blood 116:1228–1234, 2010; Blood 119:1650–7, 2012). The...

    Authors: Efren Rael, Kevin Rakszawski, Kristian Koller, Michael Bayerl, Manish Butte and Hong Zheng
    Citation: Biomarker Research 2016 4:7
  26. Genomic instability and clonal evolution are hallmarks of progressing chronic myeloid leukemia (CML). Recently, we have shown that clonal evolution and blast crisis correlate with altered expression and activi...

    Authors: Wiltrud Prinzhorn, Michael Stehle, Helga Kleiner, Sabrina Ruppenthal, Martin C. Müller, Wolf-Karsten Hofmann, Alice Fabarius and Wolfgang Seifarth
    Citation: Biomarker Research 2016 4:5
  27. Stage I lung adenocarcinoma is usually not treated with adjuvant chemotherapy; however, around half of these patients do not survive 5 years. Therefore, a reliable prognostic biomarker for early stage patients...

    Authors: Marcin Krzystanek, Judit Moldvay, David Szüts, Zoltan Szallasi and Aron Charles Eklund
    Citation: Biomarker Research 2016 4:4
  28. RECQ helicase family members act as guardians of the genome to assure proper DNA metabolism in response to genotoxic stress. Hematological malignancies are characterized by genomic instability that is possibly...

    Authors: Elena Viziteu, Alboukadel Kassambara, Philippe Pasero, Bernard Klein and Jerome Moreaux
    Citation: Biomarker Research 2016 4:3
  29. Acute lymphoblastic leukemia is the most common malignant cancer in childhood. The signs and symptoms of childhood cancer are difficult to recognize, as it is not the first diagnosis to be considered for nonsp...

    Authors: Marcio de Souza Cavalcante, José Camilo Torres-Romero, Marina Duarte Pinto Lobo, Frederico Bruno Mendes Batista Moreno, Leonardo Primo Bezerra, Diego Silva Lima, Jesamar Correia Matos, Renato de Azevedo Moreira and Ana Cristina de Oliveira Monteiro-Moreira
    Citation: Biomarker Research 2016 4:1
  30. Plasmablastic lymphoma (PBL) is a rare and aggressive subtype of non-Hodgkin diffuse large B-cell lymphoma originally with a predilection to the oral cavity of patients infected with HIV. However, PBL of extra...

    Authors: Makoto Hirosawa, Hiroaki Morimoto, Ryo Shibuya, Shohei Shimajiri and Junichi Tsukada
    Citation: Biomarker Research 2015 3:28
  31. Blood transfusion is central in the prevention and treatment of certain chronic complications of sickle cell disease. It is indispensible in correcting anaemias as well as in the practice of exchange blood tra...

    Authors: Umar Kangiwa, Obike Ibegbulam, Sunday Ocheni, Anazoeze Madu and Ndakosu Mohammed
    Citation: Biomarker Research 2015 3:26
  32. Asian Indians have a high incidence of type 2 diabetes, but factors associated with glycemic progression in this population are not understood. MicroRNAs are emerging as important mediators of glucose homeosta...

    Authors: Elena Flowers, Meghana Gadgil, Bradley E. Aouizerat and Alka M. Kanaya
    Citation: Biomarker Research 2015 3:22
  33. The paper by Rachidi et al. suggests that antiplatelet drugs may play a role in ameliorating the clinical outcome in a large series of patients with head and neck cancer managed with either surgery or radiation. ...

    Authors: Carlo Furlan, Agostino Steffan, Jerry Polesel, Marco Trovo, Carlo Gobitti, Emanuela Vaccher, Diego Serraino, Luigi Barzan and Giovanni Franchin
    Citation: Biomarker Research 2015 3:25
  34. The presence of chromosomal abnormalities is one of the most important criteria for leukaemia diagnosis and management. Infant leukaemia is a rare disease that affects children in their first year of life. It ...

    Authors: Sabrina Tosi, Yasser Mostafa Kamel, Temitayo Owoka, Concetta Federico, Tony H. Truong and Salvatore Saccone
    Citation: Biomarker Research 2015 3:21
  35. Rheumatoid arthritis (RA) is a chronic inflammatory disease that preferentially affects joints, and characterized by an approximately two-fold increased risk of cardiovascular diseases compared with the genera...

    Authors: Mickael Essouma and Jean Jacques N. Noubiap
    Citation: Biomarker Research 2015 3:24
  36. Alcoholic hepatitis (AH) is caused by acute inflammation of the liver in patients that consume excessive amounts of alcohol, usually in a background of cirrhosis. AH can range from mild to severe, life threate...

    Authors: Erik Rahimi and Jen-Jung Pan
    Citation: Biomarker Research 2015 3:20
  37. Immune thrombocytopenia is an autoimmune disease with abnormal biomarkers. Immune thrombocytopenia pathogenesis is a complicated process in which the patient’s immune system is activated by platelet autoantige...

    Authors: Lingjia Yu, Chunmei Zhang, Liping Zhang, Yongyu Shi and Xuebin Ji
    Citation: Biomarker Research 2015 3:19
  38. Prorenin and renin are both involved in atherosclerosis. However, the role of plasma prorenin and renin in the development and progression of coronary artery disease (CAD) is still not clear. Thus, we aimed to...

    Authors: Gakuro Yoshida, Masanori Kawasaki, Ichijiro Murata, Yuka Hayakawa, Takuma Aoyama, Nagisa Miyazaki, Yoshihisa Yamada, Kazuhiko Nishigaki, Yoshie Arai, Fumiaki Suzuki and Shinya Minatoguchi
    Citation: Biomarker Research 2015 3:18

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