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Fig. 1 | Biomarker Research

Fig. 1

From: Bortezomib induced peripheral neuropathy and single nucleotide polymorphisms in PKNOX1

Fig. 1

(A) demonstrates the frequencies of SNPs rs2839629 and rs915854. Wilde type: light grey; heterozygous mutation: dark grey; homozygous mutation: black. For rs2839629: wild type = G, heterozygous = A/G, homozygous = A; for rs915854: wild type = C, heterozygous = C/T, homozygous = T. (B-C) display the frequencies of SNPs rs2839629 (data evaluable in 77 patients; no BIPN: n = 10; BIPN without pain: n = 35; painful BIPN: n = 32) and rs915854 (data evaluable in 78 patients; no BIPN: n = 10; BIPN without pain: n = 35; painful BIPN: n = 33) in different patient subgroups. Homozygous mutated rs2839629 and rs915854 genotypes were significantly enriched in painful BIPN (for both: Chi-square test P < 0.0001). BIPN - bortezomib induced peripheral neuropathy; Hetero - heterozygous; Homo - homozygous; WT - wild type

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