Table 4 Comparison of the operating characteristics of BFS and other widely used fibrosis scores to detect high risk of advanced fibrosis (F3-F4)
From: Circulating bone morphogenetic protein 8A is a novel biomarker to predict advanced liver fibrosis
BFS | APRI | FIB-4 | |||
|---|---|---|---|---|---|
Operating characteristics | ≥ 0.46 | < 0.5 | ≥ 1.5 | < 1.30 | ≥ 2.67 |
Accuracy | 78.8 | 62.3 | 60.0 | 64.7 | 65.9 |
% | 36.5 | 54.1 | 10.6 | 42.4 | 16.5 |
SN | 69.7 | 60.6 | 12.1 | 78.8 | 27.3 |
SP | 84.6 | 63.5 | 90.4 | 55.8 | 90.4 |
PPV | 74.2 | 51.3 | 44.4 | 53.1 | 64.3 |
NPV | 81.5 | 71.7 | 61.8 | 80.6 | 66.2 |
LR + | 4.5 | 1.7 | 1.3 | 1.8 | 2.8 |
LR- | 0.4 | 0.6 | 1.0 | 0.4 | 0.8 |