Table 3 The 7-DMR Model Performance Metrics, Values presented as: Mean, (95% C.I.)
Performance metric | Discovery cohort (n = 96) | Independent validation cohort (n = 81) | Plasma cohort (n = 106) |
|---|---|---|---|
AUC | 0.97 (0.93-1.00) | 0.96 (0.92-1.00) | 0.94 (0.86-1.00) |
Sensitivity | 0.89 (0.82–0.95) | 0.92 (0.86–0.98) | 0.81 (0.73–0.88) |
Specificity | 0.94 (0.89–0.99) | 1.00 (1.00–1.00) | 0.98 (0.95-1.00) |
Accuracy | 0.90 (0.84–0.96) | 0.94 (0.89–0.99) | 0.93 (0.89–0.98) |
NPV | 0.63 (0.53–0.72) | 0.77 (0.68–0.86) | 0.94 (0.89–0.99) |
PPV | 0.99 (0.96-1.00) | 1.00 (1.00–1.00) | 0.91 (0.86–0.97) |