Novel insights into the multifaceted roles of m6A-modified LncRNAs in cancers: biological functions and therapeutic applications

Tang, Jinxin; Zhang, Jinhui; Lu, Yu; He, Jieyu; Wang, Hua; Liu, Binfeng; Tu, Chao; Li, Zhihong

doi:10.1186/s40364-023-00484-7

Table 2 The multifaceted roles of M⁶A-modified lncRNAs in human cancers

From: Novel insights into the multifaceted roles of m⁶A-modified LncRNAs in cancers: biological functions and therapeutic applications

Cancers	M⁶A-modified lncRNAs	Expression level	Functions	References
Colorectal cancer	XIST	Upregulated	Promote cell proliferation and metastasis	[107]
	GAS5	Downregulated	Inhibit cancer progression	[108]
	RP11	Upregulated	Promote metastasis	[110]
Gastric cancer	LINC01320	Upregulated	Promote cell proliferation	[92]
Gastric cancer	THAP7-AS1	Upregulated	Promote metastasis and cell proliferation	[113]
Esophageal squamous cell carcinoma	LINC00022	Upregulated	Promote cell proliferation	[116]
Esophageal squamous cell carcinoma	MALAT1	/	Promote metastasis	[90]
Hepatocellular carcinoma	lnc-CTHCC	Upregulated	Promote angiogenesis	[96]
	LNCAROD	Upregulated	Promote glycolysis	[98]
	LINC00958	Upregulated	Facilitate lipogenesis	[118]
Pancreatic cancer	DICER1-AS1	Downregulated	Inhibit glycolysis	[99]
	WTAPP1	Upregulated	Promote cell proliferation	[122]
	KCNK15-AS1	Downregulated	Inhibit cell proliferation	[123]
Nasopharyngeal carcinoma	ZFAS1	Upregulated	Regulate autophagy level	[127]
Nasopharyngeal carcinoma	FAM225A	Upregulated	Promote cell proliferation	[128]
Lung cancer	MALAT1	Upregulated	Promote drug resistance and metastasis	[135]
	ABHD11-AS1	Upregulated	Promote glycolysis	[136]
	AC138035.1 et al.	/	/	[138]
	SVIL-AS1	Downregulated	Inhibit cell proliferation	[142]
Prostate cancer	NEAT1-1	Upregulated	Promote metastasis	[88]
Prostate cancer	PCAT6	Upregulated	Promote metastasis	[89]
Cervical cancer	KCNMB2-AS1	Upregulated	Facilitate cancer progression	[144]
Cervical cancer	FOXD2-AS1	Upregulated	Facilitate cancer progression	[145]
Endometrial carcinoma	FENDDR	Downregulated	Inhibit cell proliferation	[93]
Endometrial carcinoma	AL645568.1 et al.	/	/	[148]
Ovarian cancer	AC010894.3 et al.	/	/	[150]
	AC008669.1 et al.	/	/	[151]
	RHPN1-AS1	Upregulated	Promote cell proliferation and metastasis	[152]
Bladder cancer	AC020911.1 et al.	/	/	[155]
Bladder cancer	ZNRD1-AS1 et al.	/	/	[156]
Renal cell carcinoma	NEAT1	Downregulated	Inhibit cell proliferation	[158]
Renal cell carcinoma	Lnc-LSG1	Downregulated	Inhibit metastasis	[159]
Thyroid cancer	HAGLR	Upregulated	Promote cell proliferation	[162]
	MALAT1	Upregulated	Promote cell proliferation	[164, 165]
	PSMG3-AS1 et al.	/	/	[167]
	AC139795.2 et al.	/	/	[168]
Breast cancer	MIR210HG	Upregulated	Promote cell proliferation	[172]
Breast cancer	LINC00958	Upregulated	Promote cell proliferation	[173]
Multiple myeloma	LOC606724	Upregulated	Promote drug resistance	[101]
Multiple myeloma	SNHG1	Upregulated	Promote drug resistance	[101]
Lymphoma	TRERNA1	Upregulated	Promote cell proliferation	[177]
Leukemia	NEAT1	Downregulated	Promote apoptosis	[180]
Leukemia	AC025430.1 et al.	/	/	[182]
Osteosarcoma	ZBTB32 et al.	/	/	[186]
	AP003119.2 et al.	/	/	[187]
	FOXD2-AS1	Upregulated	Promote cell proliferation and metastasis	[188, 189]
	PVT1	Upregulated	Promote cell proliferation	[190,191,192,193]
Skin cutaneous melanoma	RP11-775D22.3 et al.	/	/	[195]
Glioma	C6orf3 et al.	/	/	[198]
Glioblastoma	CASC9	Upregulated	Promote glycolysis	[200]
Head and neck squamous cell carcinoma	GRHL3-AS1 et al.	/	/	[203]
Head and neck squamous cell carcinoma	LNCAROD	Upregulated	Promote cell proliferation	[204]
Oral squamous cell carcinoma	AC079684.2 et al.	/	/	[206]
Oral squamous cell carcinoma	MALAT1	Upregulated	Promote cell proliferation	[207]
Laryngeal squamous cell carcinoma	KCNQ1OT1	Upregulated	Promote cell proliferation	[209]

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ISSN: 2050-7771

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