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Fig. 5 | Biomarker Research

Fig. 5

From: Novel insights into the multifaceted roles of m6A-modified LncRNAs in cancers: biological functions and therapeutic applications

Fig. 5

M6A-modified lncRNAs in HCC. LINC00958 promotes HCC lipogenesis via METTL3/LINC00958/miR-3619-5P/HDGF/HRP-3/MEK1/2/ERK axis; METTL3-mediated m6A-modified Lnc-CTHCC functions by locating hnRNPK to the promoter of YAP1 gene, leading to promoted HCC angiogenesis; LINAROD is modified by METTL3 and stabilized by IGF2BP1, which functions by both inducing SRSF3 and inhibiting miR-145-5P to induce PKM2, leading to promoted HCC glycolysis

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