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Fig. 7 | Biomarker Research

Fig. 7

From: LncRNA AC006064.4–201 serves as a novel molecular marker in alleviating cartilage senescence and protecting against osteoarthritis by destabilizing CDKN1B mRNA via interacting with PTBP1

Fig. 7

Gm49317-201 and CDKN1B affects post-traumatic OA in vivo. A Establishment of a rescue model for mice post-traumatic OA targeting Gm49317-201 and CDKN1B. B Representative images of GFP staining revealed the specific adeno-associated virus (AAV) efficiently infected the cartilage of different groups. Scale bar, 200 µm. C Representative images of Safranin O / Fast green staining in mice cartilage of different groups. Scale bar, 200 µm. D 3D reconstruction images of micro-CT scanning of the knees and osteophytes (yellow arrow). E Representative images of IF staining for Mmp3 in mice cartilage of different groups. Scale bars, 200 µm and 50 µm. F Fluorescence intensity of FISH staining and IF staining, OARSI grade according to Safranin O / Fast green staining and number of osteophytes for micro-CT scanning in mice cartilage of different groups (n = 10) ** p < 0.01, *** p < 0.001

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