New insights into the function of Interleukin-25 in disease pathogenesis

Biomarker Research

Table 1 Commonality and differences between IL-25 and IL-17 A

Comparative targets		IL-25	IL-17A	References
Biological Features	Homology	The homology of IL-25 to IL-17A is 16%.		[3, 45,46,47]
Biological Features	Form of generation	In the form of disulfide-linked dimers.		[1,2,3]
Cellular sources		Th2 cells, mast cells, macrophages, etc.	Th17 cells	[1, 2]
Factors associated with signalling pathways	IL-17RA	The co-receptor		[5, 7]
	TRAF6	Participate in the activation of the NF-κB pathway.		[12, 18]
	Act1	Be recruited into IL-25 and IL-17A related signalling pathways.		[7, 10,11,12,13,14]
	TRAF4	Mediate signaling downstream.	Compete with TRAF6 for the TRAF binding domain on Act1	[22, 23]
Performance in different diseases	Psoriasis	Participate in promoting psoriasis progression.		[26, 50,51,52,53,54]
	Contact hypersensitivity	IL-25 promotes higher IL-17A expression		[44]
	Experimental autoimmune encephalomyelitis	IL-25 could work as a receptor antagonist of IL-17A function.		[59]
	Rheumatoid arthritis			[60]

ISSN: 2050-7771