Fig. 3
From: New insights into the function of Interleukin-25 in disease pathogenesis
IL-25 regulates tumor progression via diverse pathways. In tumor supportive (The left), IL-25 could induce MVP to aggravate chemoresistance. IL-25 might promote tumor proliferation via LMW-E. And also, IL-25 promotes cancer stem cell self-renewal by inducing JAK/STAT3 signaling pathway. IL-25 could induce macrophages to secrete the chemokine CXCL10, which in turn activates the EMT. In tumor suppressive (The right), IL-25 mainly induces apoptosis in tumor cells by activating caspase enzymes. IL-25 contributes to promote the entry of infiltrating eosinophils into the tumor microenvironment and mediates the killing of tumor cells. MEC, refer in particular to nonmalignant mammary epithelial cells. Black arrow indicates that IL-25 promotes the reaction, red arrow indicates that IL-25 inhibits the reaction. The image is produced by Adobe Illustrator