Fig. 2
From: New insights into the function of Interleukin-25 in disease pathogenesis
IL-25 is produced by various cell populations under different conditions. Th2 cells, mast cells, and macrophages are all capable of secreting IL-25 (Part A). Epithelial cells have been a major source of IL-25. Keratin-forming cells could produce IL-25 and IL-25R, which in combination further promote the progression of psoriasis (Part B). IL-25 and cysLTs from intestinal tuft cells could rapidly activate ILC2 by activating AP-1, followed by selective mobilization of NF-κB and NFAT, to clear the intestinal inflammation caused by helminth infection (Part C). One subpopulation of mouse thymic epithelial cells could generate IL-25 and further participate in thymic immunity (Part D). The image is produced by Adobe Illustrator