Fig. 8
From: HMGA1 augments palbociclib efficacy via PI3K/mTOR signaling in intrahepatic cholangiocarcinoma
Schematic depiction of the mechanism by which HMGA1 induces tumor progression mediated by the CCND1/CDK4/CDK6 pathway.
HMGA1 promotes iCCA progression via promoting CCND1 transcription and activating the PI3K signaling pathway. HMGA1 can induce the transcription and expression of CCND1 and eventually promote iCCA progression. Besides, CCND1/CDK4/CDK6-elevated expression after CDK4/6 inhibitors is thought to function via activation of the upstream PI3K/AKT pathway. Moreover, CDK4/6 inhibitors exert enhanced therapeutic effects in iCCA when combined with PI3K inhibitors to inhibit tumor progression