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Fig. 7 | Biomarker Research

Fig. 7

From: HMGA1 augments palbociclib efficacy via PI3K/mTOR signaling in intrahepatic cholangiocarcinoma

Fig. 7

PF-04691502 and palbociclib show synergistic effects in vivo.

A, Top: growth curve for subcutaneous xenograft tumors treated with vehicle, palbociclib (50 mg/kg), PF-04691502 (20 mg/kg) or the combination. Bottom: waterfall plot showing the tumor volume change (at day 35) relative to baseline volume (at day 7). Each bar represents one xenograft tumor.

B, Changes in body weight of indicated groups of nude mice models with subcutaneous xenograft tumors were observed.

C, Representative HE staining images of liver samples from each group.

D, Numbers of metastatic lesions on the surface of the liver.

E, Changes in body weight of nude mice model with tail vein injection were shown.

F, Representative indicated proteins expression of tumors assessed via western blot.

Data were shown as mean ± SEM. n.s. represents not significant. *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001 as calculated by the two-way ANOVA test. Scale bar: 50 μm

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